Optical coherence tomography for rapid tissue screening and directed histological sectioning.

In pathology, histological examination of the tissue is the "gold standard" to diagnose various diseases. It has contributed significantly toward identifying the abnormalities in tissues and cells, but has inherent drawbacks when used for fast and accurate diagnosis. These limitations include the lack of in vivo observation in real time and sampling errors due to limited number and area coverage of tissue sections. Its diagnostic yield also varies depending on the ability of the physician and the effectiveness of any image guidance technique that may be used for tissue screening during excisional biopsy. In order to overcome these current limitations of histology-based diagnostics, there are significant needs for either complementary or alternative imaging techniques which perform non-destructive, high resolution, and rapid tissue screening. Optical coherence tomography (OCT) is an emerging imaging modality which allows real-time cross-sectional imaging with high resolutions that approach those of histology. OCT could be a very promising technique which has the potential to be used as an adjunct to histological tissue observation when it is not practical to take specimens for histological processing, when large areas of tissue need investigating, or when rapid microscopic imaging is needed. This review will describe the use of OCT as an image guidance tool for fast tissue screening and directed histological tissue sectioning in pathology.

[1]  Zhongping Chen,et al.  Second harmonic optical coherence tomography. , 2004, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.

[2]  K. Cleary,et al.  Image-guided interventions : technology and applications , 2008 .

[3]  A. Fercher,et al.  Measurement of intraocular distances by backscattering spectral interferometry , 1995 .

[4]  Optimal optical coherence tomography-based measures in the diagnosis of clinically significant macular edema: retinal volume vs foveal thickness. , 2007, Archives of ophthalmology.

[5]  B. Bouma,et al.  Optical coherence tomography for imaging the vulnerable plaque. , 2006, Journal of biomedical optics.

[6]  Matthew Brenner,et al.  Feasibility study of normal and septic tracheal imaging using optical coherence tomography , 2004, Lasers in surgery and medicine.

[7]  David Tolliver,et al.  Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears. , 2010, Arthritis and rheumatism.

[8]  Iwona Gorczynska,et al.  Anterior segment imaging with Spectral OCT system using a high-speed CMOS camera. , 2009, Optics express.

[9]  J. Fujimoto,et al.  Optical coherence tomography of the human retina. , 1995, Archives of ophthalmology.

[10]  U. I. Urbana-Champaign,et al.  Non-linear interferometric vibrational imaging , 2003, Conference on Lasers and Electro-Optics, 2003. CLEO '03..

[11]  Thomas E. Milner,et al.  Optical Doppler Tomography , 1999, Definitions.

[12]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[13]  John V Frangioni,et al.  New technologies for human cancer imaging. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  Amy L Oldenburg,et al.  Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues. , 2008, Optics express.

[15]  D. Sampson,et al.  Three-dimensional optical coherence tomography of whole-muscle autografts as a precursor to morphological assessment of muscular dystrophy in mice. , 2008, Journal of biomedical optics.

[16]  W. Drexler,et al.  Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography. , 2009, Optics express.

[17]  Bin Liu,et al.  Theoretical and practical considerations on detection performance of time domain, Fourier domain, and swept source optical coherence tomography. , 2007, Journal of biomedical optics.

[18]  Yan Li,et al.  High‐speed optical coherence tomography for management after laser in situ keratomileusis , 2006, Journal of cataract and refractive surgery.

[19]  Joseph M. Schmitt,et al.  Optical coherence tomography (OCT): a review , 1999 .

[20]  Michael W. Jenkins,et al.  4D embryonic cardiography using gated optical coherence tomography. , 2006, Optics express.

[21]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[22]  W. Drexler,et al.  Minimum distance mapping using three-dimensional optical coherence tomography for glaucoma diagnosis. , 2007, Journal of biomedical optics.

[23]  R M Henkelman,et al.  MR systems for image-guided therapy. , 1998, Journal of magnetic resonance imaging : JMRI.

[24]  Assessing Diabetic Macular Edema with Optical Coherence Tomography , 2010 .

[25]  John A. Evans,et al.  Comprehensive volumetric optical microscopy in vivo , 2006, Nature Medicine.

[26]  J. Duker,et al.  Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration. , 2009, Optics express.

[27]  M. Smith,et al.  A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma , 2001, Gut.

[28]  R. John,et al.  In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes , 2010, Proceedings of the National Academy of Sciences.

[29]  B. Wong,et al.  In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients , 2005, The Laryngoscope.

[30]  S. Mclaughlin,et al.  Influence of frozen-section analysis of sentinel lymph node and lumpectomy margin status on reoperation rates in patients undergoing breast-conservation therapy. , 2008, Journal of the American College of Surgeons.

[31]  S. Vaezy,et al.  In vivo feasibility of image-guided transvaginal focused ultrasound therapy for the treatment of intracavitary fibroids. , 2004, Fertility and sterility.

[32]  P. Drew,et al.  Laparoscopic ultrasound for the detection of hepatic metastases during laparoscopic colorectal cancer surgery , 2000, Diseases of the colon and rectum.

[33]  Uretz J. Oliphant,et al.  Optical Coherence Tomography: The Intraoperative Assessment of Lymph Nodes in Breast Cancer , 2010, IEEE Engineering in Medicine and Biology Magazine.

[34]  Stuart S Kaplan,et al.  Clinical utility of bilateral whole-breast US in the evaluation of women with dense breast tissue. , 2001, Radiology.

[35]  T. Milner,et al.  Review of polarization sensitive optical coherence tomography and Stokes vector determination. , 2002, Journal of biomedical optics.

[36]  T. Yatagai,et al.  Three-dimensional imaging of macular holes with high-speed optical coherence tomography. , 2007, Ophthalmology.

[37]  Jun Zhang,et al.  Advances in oral cancer detection using optical coherence tomography , 2005, IEEE Journal of Selected Topics in Quantum Electronics.

[38]  Elena V Zagaynova,et al.  In vivo optical coherence tomography feasibility for bladder disease. , 2002, The Journal of urology.

[39]  S. Boppart,et al.  Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer , 2004, Breast Cancer Research and Treatment.

[40]  B. Bouma,et al.  Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography. , 1999, Optics letters.

[41]  R. John,et al.  Dynamic spectral-domain optical coherence elastography for tissue characterization , 2010, Optics express.

[42]  A. Sahai,et al.  Endoscopic ultrasound guided fine needle aspiration biopsy: a large single centre experience , 1999, Gut.

[43]  Eiji Toyota,et al.  Assessment of coronary arterial plaque by optical coherence tomography. , 2006, The American journal of cardiology.

[44]  Adeel Ahmad,et al.  Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography. , 2009, Optics express.

[45]  S. Yun,et al.  High-speed spectral-domain optical coherence tomography at 1.3 mum wavelength. , 2003, Optics express.

[46]  A Hartov,et al.  Intra-Operative Image Updating , 2001, Stereotactic and Functional Neurosurgery.

[47]  Ming Li,et al.  Real‐time interactive MRI‐guided cardiac surgery: Aortic valve replacement using a direct apical approach , 2006, Magnetic resonance in medicine.

[48]  Iwona Gorczynska,et al.  Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography. , 2009, Optics express.

[49]  Alexander Wei,et al.  Magnetomotive contrast for in vivo optical coherence tomography. , 2005, Optics express.

[50]  S. Yun,et al.  High-speed optical frequency-domain imaging. , 2003, Optics express.

[51]  S. Boppart,et al.  Needle-based reflection refractometry of scattering samples using coherence-gated detection. , 2007, Optics express.

[52]  Stephen A. Boppart,et al.  Molecular histopathology by nonlinear interferometric vibrational imaging , 2011, European Conference on Biomedical Optics.

[53]  Bertil Bouillon,et al.  Image-guided spine surgery: state of the art and future directions , 2009, European Spine Journal.

[54]  J. Fujimoto,et al.  Imaging needle for optical coherence tomography. , 2000, Optics letters.

[55]  Kang Zhang,et al.  Graphics processing unit accelerated non-uniform fast Fourier transform for ultrahigh-speed, real-time Fourier-domain OCT , 2010, Optics express.

[56]  J. Baker,et al.  MRI-guided vacuum-assisted breast biopsy with a handheld portable biopsy system. , 2006, AJR. American journal of roentgenology.

[57]  Freddy T. Nguyen,et al.  Intraoperative evaluation of breast tumor margins with optical coherence tomography. , 2009, Cancer research.

[58]  J. Fujimoto,et al.  Three-dimensional endomicroscopy using optical coherence tomography , 2007 .

[59]  T. Yatagai,et al.  Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. , 2007, Ophthalmology.

[60]  B E Bouma,et al.  Forward-imaging instruments for optical coherence tomography. , 1997, Optics letters.

[61]  Claudio Vinegoni,et al.  Spectroscopic spectral-domain optical coherence microscopy. , 2006, Optics letters.

[62]  S. Boppart,et al.  Computational methods for analysis of human breast tumor tissue in optical coherence tomography images. , 2006, Journal of biomedical optics.

[63]  S. Gulec.  PET probe‐guided surgery , 2007, Journal of surgical oncology.

[64]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[65]  J H Siewerdsen,et al.  Investigation of C‐Arm Cone‐Beam CT‐Guided Surgery of the Frontal Recess , 2005, The Laryngoscope.

[66]  Matthew Brenner,et al.  Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor. , 2008, Journal of biomedical optics.

[67]  Daniel L Marks,et al.  Optical probes and techniques for molecular contrast enhancement in coherence imaging. , 2005, Journal of biomedical optics.

[68]  J. Fujimoto,et al.  Intraoperative assessment of microsurgery with three-dimensional optical coherence tomography. , 1998, Radiology.

[69]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[70]  Stephen A. Boppart,et al.  Sonification of optical coherence tomography data and images , 2010, Optics express.

[71]  Yuuki Watanabe,et al.  Real-time display on Fourier domain optical coherence tomography system using a graphics processing unit. , 2009, Journal of biomedical optics.

[72]  Brett E. Bouma,et al.  In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography , 2005, Circulation.

[73]  David W Townsend,et al.  Image‐Guided Cancer Therapy Using PET/CT , 2004, Cancer journal.

[74]  Woonggyu Jung,et al.  In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror. , 2007, Optics letters.

[75]  Robert N Weinreb,et al.  Spectral domain-optical coherence tomography to detect localized retinal nerve fiber layer defects in glaucomatous eyes. , 2009, Optics express.

[76]  Freddy T. Nguyen,et al.  Optical Biopsy of Lymph Node Morphology using Optical Coherence Tomography , 2005, Technology in cancer research & treatment.