Outbreak of systemic aspergillosis in a neonatal intensive care unit

Summary. Small pre‐term neonates are susceptible to cutaneous aspergillosis because of their immature immune system and because of the vulnerability of their skin. In addition, the common therapy with broad‐spectrum antibiotic drugs and corticoids creates a favourable milieu for fungal superinfections. We present four pre‐term neonates who succumbed to cutaneous aspergillosis that subsequently developed into a systemic infection. The source of the infection proved to be contaminated latex finger stalls. Three of the four patients died. The poor prognosis for systemic aspergillosis can only be improved by an early therapy with amphotericin B, possibly in liposomal form.

[1]  T. J. Walsh,et al.  Nosocomial aspergillosis: Environmental microbiology, hospital epidemiology, diagnosis and treatment , 1989, European Journal of Epidemiology.

[2]  M. Hocking,et al.  Nosocomial infection with Rhizopus microsporus in preterm infants: association with wooden tongue depressors , 1996, The Lancet.

[3]  S. Baer,et al.  Invasive fungal dermatitis in the < or = 1000-gram neonate. , 1995, Pediatrics.

[4]  J. Meis,et al.  Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis. , 1995, Journal of clinical pathology.

[5]  R. Sievers,et al.  Therapie mit liposomalem Amphotericin B bei neonataler Pilzsepsis mit enzephalitischer und osteoarthritischer Beteiligung , 1994 .

[6]  V. Andriole.  Infections with Aspergillus species. , 1993, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  R. Schneider,et al.  Invasive Aspergillus infections in a pediatric hospital: a ten‐year review , 1993, The Pediatric infectious disease journal.

[8]  R. Faix,et al.  Primary cutaneous aspergillosis in a preterm infant. , 1993, American Journal of Perinatology.

[9]  R. Rüchel,et al.  Rapid microscopical diagnosis of deep‐seated mycoses following maceration of fresh specimens and staining with optical brighteners , 1993, Mycoses.

[10]  M. Edwards,et al.  Invasive aspergillosis in neonates: report of five cases and literature review , 1992, The Pediatric Infectious Disease Journal.

[11]  B. Urlesberger,et al.  Liposomal amphotericin-B (AmBisome) for treatment of disseminated fungal infections in two infants of very low birth weight. , 1992, Pediatrics.

[12]  J. Troy,et al.  Multiple Cutaneous Ulcers in a Premature Neonate , 1991, Pediatric dermatology.

[13]  구자홍,et al.  Aspergillosis , 2020, Red Book Atlas of Pediatric Infectious Diseases.

[14]  D. Stynen,et al.  Detection of Circulating Galactomannan by Pastorex Aspergillus in Experimental Invasive Aspergillosis , 1990, Mycoses.

[15]  S. Singhi,et al.  Disseminated neonatal aspergillosis. , 1989, Indian Pediatrics.

[16]  D. Schwartz,et al.  Disseminated neonatal aspergillosis: report of a fatal case and analysis of risk factors , 1988, The Pediatric infectious disease journal.

[17]  D. Stevenson,et al.  Neonatal Aspergillosis , 1986, Clinical pediatrics.

[18]  R. Jones,et al.  Outbreak of primary cutaneous aspergillosis related to intravenous arm boards. , 1986, The Journal of pediatrics.

[19]  R. Holzman,et al.  Nosocomial Fungal Infection During Hospital Renovation , 1985, Infection Control.

[20]  A. Sober,et al.  Primary cutaneous aspergillosis in a premature neonate , 1980, The British journal of dermatology.

[21]  H. Mangurten,et al.  Neonatal aspergillosis accompanying fulminant necrotising enterocolitis. , 1979, Archives of Disease in Childhood.

[22]  F. Gonzalez-crussi,et al.  Acute Disseminated Aspergillosis During the Neonatal Period , 1979, La Clinica pediatrica.