Astaxanthin: A Promising Therapeutic Agent for Organ Fibrosis.

[1]  J. DiNicolantonio,et al.  Nutraceutical activation of Sirt1: a review , 2022, Open Heart.

[2]  Qian Zhang,et al.  Different Roles of Resident and Non-resident Macrophages in Cardiac Fibrosis , 2022, Frontiers in Cardiovascular Medicine.

[3]  Ji-Young Lee,et al.  Astaxanthin Attenuates the Changes in the Expression of MicroRNAs Involved in the Activation of Hepatic Stellate Cells , 2022, Nutrients.

[4]  Yuquan Wei,et al.  Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases , 2022, Acta pharmaceutica Sinica. B.

[5]  L. Du,et al.  Benefits and Safety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease , 2022, Frontiers in Nutrition.

[6]  Cheng Wang,et al.  Macrophage Polarization and Its Role in Liver Disease , 2021, Frontiers in Immunology.

[7]  S. Sabiu,et al.  Astaxanthin-Mediated Bacterial Lethality: Evidence from Oxidative Stress Contribution and Molecular Dynamics Simulation , 2021, Oxidative medicine and cellular longevity.

[8]  H. Nishida,et al.  The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes , 2021, Nutrients.

[9]  S. Ryter,et al.  Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis. , 2021, Annual review of pathology.

[10]  Jiafu Li,et al.  Naringenin: A Promising Therapeutic Agent against Organ Fibrosis , 2021, Oxidative medicine and cellular longevity.

[11]  M. Aschner,et al.  Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[12]  Runzhi Li,et al.  Astaxanthin from Haematococcus pluvialis alleviates obesity by modulating lipid metabolism and gut microbiota in mice fed a high-fat diet. , 2021, Food & function.

[13]  Ming Yang,et al.  Astaxanthin Prevents Diet-Induced NASH Progression by Shaping Intrahepatic Immunity , 2021, International journal of molecular sciences.

[14]  M. Martinez-Fierro,et al.  Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease , 2021, Molecules.

[15]  V. Shenoy,et al.  Renin Angiotensin Aldosterone System in Pulmonary Fibrosis: Pathogenesis to Therapeutic Possibilities. , 2021, Pharmacological research.

[16]  R. Chignola,et al.  Effects of Combination Treatments with Astaxanthin-Loaded Microparticles and Pentoxifylline on Intracellular ROS and Radiosensitivity of J774A.1 Macrophages , 2021, Molecules.

[17]  A. Shatoor,et al.  Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1 , 2021, Saudi Journal of Biological Sciences.

[18]  Jing Wang,et al.  The Mechanism of CD8+ T Cells for Reducing Myofibroblasts Accumulation during Renal Fibrosis , 2021, Biomolecules.

[19]  J. Epstein,et al.  Immune Cells and Immunotherapy for Cardiac Injury and Repair , 2021, Circulation research.

[20]  R. Chignola,et al.  Phagocytosis of Astaxanthin-Loaded Microparticles Modulates TGFβ Production and Intracellular ROS Levels in J774A.1 Macrophages , 2021, Marine drugs.

[21]  Jin Jin,et al.  A double-edged sword of immuno-microenvironment in cardiac homeostasis and injury repair , 2021, Signal Transduction and Targeted Therapy.

[22]  R. Elgohary,et al.  Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor , 2021, BioMed research international.

[23]  P. González,et al.  "Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials". , 2021, Pharmacological research.

[24]  J. Hagood,et al.  Cooperative signaling between integrins and growth factor receptors in fibrosis , 2021, Journal of Molecular Medicine.

[25]  Yiming Zhang,et al.  Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins , 2020, Neural regeneration research.

[26]  T. Ota Prevention of NAFLD/NASH by Astaxanthin and β-Cryptoxanthin. , 2021, Advances in experimental medicine and biology.

[27]  Mark G. Jones,et al.  Idiopathic pulmonary fibrosis: Disease mechanisms and drug development. , 2020, Pharmacology & therapeutics.

[28]  S. Friedman,et al.  The Power of Plasticity-Metabolic Regulation of Hepatic Stellate Cells. , 2020, Cell metabolism.

[29]  Junrui Cheng,et al.  The Promising Effects of Astaxanthin on Lung Diseases. , 2020, Advances in nutrition.

[30]  A. Souza,et al.  Antioxidant and anti-inflammatory mechanisms of action of astaxanthin in cardiovascular diseases (Review) , 2020, International journal of molecular medicine.

[31]  Youn Sook Kim,et al.  Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53 , 2020, Marine drugs.

[32]  T. Wynn,et al.  Fibrosis: from mechanisms to medicines , 2020, Nature.

[33]  A. Bishayee,et al.  On a Beam of Light: Photoprotective Activities of the Marine Carotenoids Astaxanthin and Fucoxanthin in Suppression of Inflammation and Cancer , 2020, Marine drugs.

[34]  Xiaolin Wang,et al.  MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases , 2020, Gut.

[35]  Cheng Huang,et al.  Role of microRNAs in Hepatic Stellate Cells and Hepatic Fibrosis: an Update. , 2020, Current pharmaceutical design.

[36]  S. Dasgupta,et al.  Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 , 2020, Biomedicine & Pharmacotherapy.

[37]  M. Ávila,et al.  Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target? , 2020, Cells.

[38]  Haisheng Peng,et al.  Kidney-targeted Astaxanthin Natural Antioxidant Nanosystem for Diabetic Nephropathy Therapy. , 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[39]  K. Marycz,et al.  Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications , 2020, Marine drugs.

[40]  Rongrong Li,et al.  Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria‐mediated signal pathways , 2020, Journal of cellular and molecular medicine.

[41]  K. Crowe-White,et al.  Anti-Apoptotic Effects of Carotenoids in Neurodegeneration , 2020, Molecules.

[42]  Jian Li,et al.  Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis. , 2020, Biotechnology advances.

[43]  Xi Wang,et al.  Astaxanthin promotes M2 macrophages and attenuates cardiac remodeling after myocardial infarction by suppression inflammation in rats , 2020, Chinese medical journal.

[44]  R. Allsopp,et al.  Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging , 2020, Marine drugs.

[45]  Ji-Young Lee,et al.  Astaxanthin inhibits the reduction of glycolysis during the activation of hepatic stellate cells. , 2020, Life sciences.

[46]  Chuanyong Guo,et al.  Astaxanthin in Liver Health and Disease: A Potential Therapeutic Agent , 2020, Drug design, development and therapy.

[47]  Runzhi Li,et al.  Astaxanthin from Haematococcus pluvialis ameliorates the chemotherapeutic drug (doxorubicin) induced liver injury through the Keap1/Nrf2/HO-1 pathway in mice. , 2020, Food & function.

[48]  H. Too,et al.  Microbial astaxanthin biosynthesis: recent achievements, challenges, and commercialization outlook , 2020, Applied Microbiology and Biotechnology.

[49]  M. Pellegrini,et al.  Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights , 2020, Marine drugs.

[50]  E. Crouchet,et al.  Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives , 2020, Cells.

[51]  Yasufumi Sato,et al.  Targeting angiogenesis and lymphangiogenesis in kidney disease , 2020, Nature Reviews Nephrology.

[52]  Yangchao Luo,et al.  Chitosan-caseinate-dextran ternary complex nanoparticles for potential oral delivery of astaxanthin with significantly improved bioactivity. , 2020, International journal of biological macromolecules.

[53]  H. Knutsen,et al.  Safety of astaxanthin for its use as a novel food in food supplements , 2020, EFSA journal. European Food Safety Authority.

[54]  Zhenzhen Li,et al.  Ginsenosides: potential therapeutic source for fibrosis-associated human diseases , 2019, Journal of ginseng research.

[55]  L. Csernoch,et al.  Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging , 2019, Oxidative medicine and cellular longevity.

[56]  S. Tait,et al.  Mitochondria as multifaceted regulators of cell death , 2019, Nature Reviews Molecular Cell Biology.

[57]  M. Whitfield,et al.  Shared and distinct mechanisms of fibrosis , 2019, Nature Reviews Rheumatology.

[58]  Ji-Young Lee,et al.  Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells. , 2019, The Journal of nutritional biochemistry.

[59]  W. Diao,et al.  Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment. , 2019, Biochimica et biophysica acta. General subjects.

[60]  K. Cheng,et al.  siRNA- and miRNA-based therapeutics for liver fibrosis. , 2019, Translational research : the journal of laboratory and clinical medicine.

[61]  A. Dunne,et al.  The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling , 2019, Front. Cardiovasc. Med..

[62]  M. Farzaei,et al.  The Neuroprotective Effects of Astaxanthin: Therapeutic Targets and Clinical Perspective , 2019, Molecules.

[63]  Suntaek Hong,et al.  Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a , 2019, Scientific Reports.

[64]  Li Zhang,et al.  Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction , 2019, Molecular medicine reports.

[65]  P. Bickford,et al.  Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice , 2019, GeroScience.

[66]  T. Blackwell,et al.  lncITPF Promotes Pulmonary Fibrosis by Targeting hnRNP-L Depending on Its Host Gene ITGBL1. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

[67]  F. Tacke,et al.  Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications. , 2019, Molecular aspects of medicine.

[68]  J. Horowitz,et al.  Mechanisms for the Resolution of Organ Fibrosis. , 2019, Physiology.

[69]  P. Kamath,et al.  Burden of liver diseases in the world. , 2019, Journal of hepatology.

[70]  Periaswamy Sivagnanam Saravana,et al.  Astaxanthin-alpha tocopherol nanoemulsion formulation by emulsification methods: Investigation on anticancer, wound healing, and antibacterial effects. , 2018, Colloids and surfaces. B, Biointerfaces.

[71]  Cheng Yang,et al.  Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury , 2018, Cell Death & Disease.

[72]  David Roy Smith,et al.  Haematococcus lacustris: the makings of a giant-sized chloroplast genome , 2018, AoB PLANTS.

[73]  L. Dargahi,et al.  Astaxanthin: A mechanistic review on its biological activities and health benefits , 2018, Pharmacological research.

[74]  Kefeng Li,et al.  Sphingomyelin phosphodiesterase 1 (SMPD1) mediates the attenuation of myocardial infarction-induced cardiac fibrosis by astaxanthin. , 2018, Biochemical and biophysical research communications.

[75]  N. Vaziri,et al.  New insights into TGF-β/Smad signaling in tissue fibrosis. , 2018, Chemico-biological interactions.

[76]  Naoki Ito,et al.  The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial , 2018, Nutrients.

[77]  D. Schuppan,et al.  Liver fibrosis: Direct antifibrotic agents and targeted therapies. , 2018, Matrix biology : journal of the International Society for Matrix Biology.

[78]  G. Scapagnini,et al.  Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review , 2018, Nutrients.

[79]  J. Tao,et al.  Astaxanthin Promotes Nrf2/ARE Signaling to Inhibit HG-Induced Renal Fibrosis in GMCs , 2018, Marine drugs.

[80]  S. Kuo,et al.  Reparative Effects of Astaxanthin-Hyaluronan Nanoaggregates against Retrorsine-CCl4-Induced Liver Fibrosis and Necrosis , 2018, Molecules.

[81]  W. Parks,et al.  Macrophages, Wound Healing, and Fibrosis: Recent Insights , 2018, Current Rheumatology Reports.

[82]  N. Schoof,et al.  The Burden of Illness of Idiopathic Pulmonary Fibrosis: A Comprehensive Evidence Review , 2018, PharmacoEconomics.

[83]  B. Humphreys Mechanisms of Renal Fibrosis. , 2018, Annual review of physiology.

[84]  D. Letourneur,et al.  Astaxanthin-antioxidant impact on excessive Reactive Oxygen Species generation induced by ischemia and reperfusion injury. , 2018, Chemico-biological interactions.

[85]  L. Lau,et al.  Resolution of organ fibrosis , 2018, The Journal of clinical investigation.

[86]  H. Reza,et al.  Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats , 2018, Journal of dietary supplements.

[87]  C. Trollet,et al.  Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies. , 2017, Current protein & peptide science.

[88]  P. Boor,et al.  PDGF in organ fibrosis. , 2017, Molecular aspects of medicine.

[89]  M. Mack Inflammation and fibrosis. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

[90]  L. Servillo,et al.  SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection. , 2017, Antioxidants & redox signaling.

[91]  M. Islam,et al.  Astaxanthin Ameliorates Hepatic Damage and Oxidative Stress in Carbon Tetrachloride-administered Rats , 2017, Pharmacognosy research.

[92]  Qian Cai,et al.  Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1. , 2017, Biochimica et biophysica acta. General subjects.

[93]  Paul Martin,et al.  Inflammation and metabolism in tissue repair and regeneration , 2017, Science.

[94]  Mark G. Jones,et al.  Idiopathic pulmonary fibrosis , 2017, The Lancet.

[95]  S. Friedman,et al.  Mechanisms of hepatic stellate cell activation , 2017, Nature Reviews Gastroenterology &Hepatology.

[96]  Ji-Young Lee,et al.  Astaxanthin inhibits inflammation and fibrosis in the liver and adipose tissue of mouse models of diet-induced obesity and nonalcoholic steatohepatitis. , 2017, The Journal of nutritional biochemistry.

[97]  J. Mann,et al.  Epigenetics and Liver Fibrosis , 2017, Cellular and molecular gastroenterology and hepatology.

[98]  K. Meyer Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis , 2017, Expert review of respiratory medicine.

[99]  L. Liang,et al.  Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea) , 2017, Circulation.

[100]  Tsung-Ming Lee,et al.  Dapagliflozin, a Selective SGLT2 Inhibitor, Attenuated Cardiac Fibrosis by Regulating the Macrophage Polarization via STAT3 Signaling in Infarcted Rat Hearts , 2017, Free radical biology & medicine.

[101]  T. Wynn,et al.  Mechanisms of Organ Injury and Repair by Macrophages. , 2017, Annual review of physiology.

[102]  P. Bickford,et al.  Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration , 2017, GeroScience.

[103]  Ji-Young Lee,et al.  Histone deacetylase 9 plays a role in the antifibrogenic effect of astaxanthin in hepatic stellate cells. , 2017, The Journal of nutritional biochemistry.

[104]  F. Zannad,et al.  Myocardial fibrosis: biomedical research from bench to bedside , 2017, European journal of heart failure.

[105]  F. Visioli,et al.  Astaxanthin in cardiovascular health and disease: mechanisms of action, therapeutic merits, and knowledge gaps. , 2017, Food & function.

[106]  J. Rosenbloom,et al.  Human Fibrotic Diseases: Current Challenges in Fibrosis Research. , 2017, Methods in molecular biology.

[107]  H. Fujino,et al.  Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress , 2017, The Journal of Physiological Sciences.

[108]  R. Selgas,et al.  Preventing peritoneal membrane fibrosis in peritoneal dialysis patients. , 2016, Kidney international.

[109]  Chun-Chao Chang,et al.  Improved Hepatoprotective Effect of Liposome-Encapsulated Astaxanthin in Lipopolysaccharide-Induced Acute Hepatotoxicity , 2016, International journal of molecular sciences.

[110]  Xiao-ming Meng,et al.  TGF-β: the master regulator of fibrosis , 2016, Nature Reviews Nephrology.

[111]  S. Ota,et al.  What is the correct name for the type of Haematococcus Flot. (Volvocales, Chlorophyceae)? , 2016 .

[112]  Jay J. Cheng,et al.  Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products , 2016, Front. Plant Sci..

[113]  Ji-Young Lee,et al.  Astaxanthin prevents and reverses the activation of mouse primary hepatic stellate cells. , 2016, The Journal of nutritional biochemistry.

[114]  P. Bloomston,et al.  Hepatic Stellate Cells and microRNAs in Pathogenesis of Liver Fibrosis , 2016, Journal of clinical medicine.

[115]  S. Kaneko,et al.  Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E , 2015, Scientific Reports.

[116]  Y. Tomino,et al.  Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats , 2015, Peritoneal Dialysis International.

[117]  Bicheng Chen,et al.  MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7 , 2015, Laboratory Investigation.

[118]  Cuiping Mao,et al.  Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission , 2015, Journal of cellular and molecular medicine.

[119]  Youming Peng,et al.  Astaxanthin Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis , 2015, Pharmacology.

[120]  Don C Rockey,et al.  Fibrosis--a common pathway to organ injury and failure. , 2015, The New England journal of medicine.

[121]  Ji-Young Lee,et al.  Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. , 2015, Biochimica et biophysica acta.

[122]  Cuiping Mao,et al.  Astaxanthin inhibits apoptosis in alveolar epithelial cells type II in vivo and in vitro through the ROS-dependent mitochondrial signalling pathway , 2014, Journal of cellular and molecular medicine.

[123]  L. O’Neill,et al.  Metabolic Reprograming in Macrophage Polarization , 2014, Front. Immunol..

[124]  R. Sussman,et al.  A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. , 2014, The New England journal of medicine.

[125]  H. Collard,et al.  Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. , 2014, The New England journal of medicine.

[126]  Fan Wang,et al.  Protective Effect of Astaxanthin on Liver Fibrosis through Modulation of TGF-β1 Expression and Autophagy , 2014, Mediators of inflammation.

[127]  Gokare A. Ravishankar,et al.  Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review , 2014, Marine drugs.

[128]  Sara Cipolat,et al.  Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency , 2013, Cell.

[129]  Xiaodong Song,et al.  Astaxanthin ameliorates lung fibrosis in vivo and in vitro by preventing transdifferentiation, inhibiting proliferation, and promoting apoptosis of activated cells. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[130]  T. Wynn,et al.  Mechanisms of fibrosis: therapeutic translation for fibrotic disease , 2012, Nature Medicine.

[131]  J. Iredale,et al.  Macrophages: central regulators of hepatic fibrogenesis and fibrosis resolution. , 2012, Journal of hepatology.

[132]  A. Nagao Absorption and metabolism of dietary carotenoids. , 2011, BioFactors.

[133]  Giulio Gabbiani,et al.  The myofibroblast: one function, multiple origins. , 2007, The American journal of pathology.

[134]  R. McAnulty Fibroblasts and myofibroblasts: their source, function and role in disease. , 2007, The international journal of biochemistry & cell biology.

[135]  S. Krähenbühl Alterations in mitochondrial function and morphology in chronic liver disease: pathogenesis and potential for therapeutic intervention. , 1993, Pharmacology & therapeutics.