Critical role of the long non-coding RNAs (lncRNAs) in radiotherapy (RT)-resistance of gastrointestinal (GI) cancer: Is there a way to defeat this resistance?

[1]  F. Moramezi,et al.  The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers , 2024, BMC cancer.

[2]  Chengmei Huang,et al.  LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation , 2023, Nature communications.

[3]  Ruifeng Liu,et al.  Review of possible mechanisms of radiotherapy resistance in cervical cancer , 2023, Frontiers in oncology.

[4]  G. Fròsina Radiotherapy of High-grade Gliomas: Dealing With A Stalemate. , 2023, Critical reviews in oncology/hematology.

[5]  Zheng Deng,et al.  Predicting tumor repopulation through the gene panel derived from radiation resistant colorectal cancer cells , 2023, Journal of Translational Medicine.

[6]  Zilang Zhang,et al.  LncRNA OTUD6B-AS1 overexpression promoted GPX4-mediated ferroptosis to suppress radioresistance in colorectal cancer , 2023, Clinical and Translational Oncology.

[7]  Yingpeng Huang,et al.  LncRNA FBXO18-AS promotes gastric cancer progression by TGF-β1/Smad signaling , 2023, European journal of histochemistry : EJH.

[8]  Milad Shirvaliloo LncRNA H19 promotes tumor angiogenesis in smokers by targeting anti-angiogenic miRNAs. , 2023, Epigenomics.

[9]  Yao Huang,et al.  A telomerase regulation-related lncRNA signature predicts prognosis and immunotherapy response for gastric cancer , 2022, Journal of Cancer Research and Clinical Oncology.

[10]  Rui Yang,et al.  LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway , 2022, Cancer biology & therapy.

[11]  G. Shiota,et al.  NEAT1 Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing PINK1/Parkin-Mediated Mitophagy , 2022, International journal of molecular sciences.

[12]  C. Xing,et al.  Upregulation of Long Noncoding RNA MALAT1 in Colorectal Cancer Promotes Radioresistance and Aggressive Malignance , 2022, International journal of general medicine.

[13]  Y. Han,et al.  Targeting Tumor Physical Microenvironment for Improved Radiotherapy , 2022, Small methods.

[14]  M. Hashemi,et al.  Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy. , 2022, Pharmacological research.

[15]  Wen-Wei Hu,et al.  A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3 , 2022, Cell Death & Differentiation.

[16]  Liang Gao,et al.  Long non-coding RNA LINC00152 in cancer: Roles, mechanisms, and chemotherapy and radiotherapy resistance , 2022, Frontiers in Oncology.

[17]  Q. Ma,et al.  Molecular Interactions of the Long Noncoding RNA NEAT1 in Cancer , 2022, Cancers.

[18]  S. Lamon,et al.  Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle , 2022, BMC Biology.

[19]  Ji-wen He,et al.  LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis. , 2022, Neoplasma.

[20]  Xifa Zhou,et al.  SOX17-mediated MALAT1-miR-199a-HIF1α axis confers sensitivity in esophageal squamous cell carcinoma cells to radiotherapy , 2022, Cell death discovery.

[21]  Shuijun Zhang,et al.  LINC00958: A promising long non-coding RNA related to cancer. , 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  G. Calin,et al.  Targeting non-coding RNAs to overcome cancer therapy resistance , 2022, Signal Transduction and Targeted Therapy.

[23]  R. Soffietti,et al.  Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism , 2022, Nature Medicine.

[24]  Ya-Chu Yu,et al.  Down-regulated long non-coding RNA LHFPL3 antisense RNA 1 inhibits the radiotherapy resistance of nasopharyngeal carcinoma via modulating microRNA-143-5p/homeobox A6 axis , 2022, Bioengineered.

[25]  Xiao-dong Zhu,et al.  LncRNA DLGAP1-AS2 promotes the radioresistance of rectal cancer stem cells by upregulating CD151 expression via E2F1 , 2022, Translational oncology.

[26]  Hui Zhou,et al.  Recent advances of NEAT1-miRNA interactions in cancer , 2022, Acta biochimica et biophysica Sinica.

[27]  Jianping Cao,et al.  The feedback loop of ANKHD1/lncRNA MALAT1/YAP1 strengthens the radioresistance of CRC by activating YAP1/AKT signaling , 2022, Cell Death & Disease.

[28]  N. Proudfoot,et al.  Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics , 2022, Nature Reviews Molecular Cell Biology.

[29]  G. Shiota,et al.  NEAT1 Confers Radioresistance to Hepatocellular Carcinoma Cells by Inducing Autophagy through GABARAP , 2022, International journal of molecular sciences.

[30]  Shinichi Nakagawa,et al.  NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. , 2021, Cell metabolism.

[31]  Yuan Zhang,et al.  Long non-coding RNAs: Biogenesis, functions, and clinical significance in gastric cancer , 2021, Molecular therapy oncolytics.

[32]  N. Magné,et al.  A Review of the Role of Hypoxia in Radioresistance in Cancer Therapy , 2021, Medical science monitor : international medical journal of experimental and clinical research.

[33]  M. Wolter,et al.  The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma , 2021, Cell Death & Disease.

[34]  Kefeng Wang,et al.  LncRNA H19: A novel oncogene in multiple cancers , 2021, International journal of biological sciences.

[35]  K. Ganbarov,et al.  Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells , 2021, BioMed research international.

[36]  Yanyong Yang,et al.  Long non-coding RNA ANRIL promotes homologous recombination-mediated DNA repair by maintaining ATR protein stability to enhance cancer resistance , 2021, Molecular Cancer.

[37]  Jiajia Zhang,et al.  LncRNA CRYM-AS1 Inhibits Gastric Cancer Progression via Epigenetically Regulating CRYM. , 2021, Annals of clinical and laboratory science.

[38]  Hua Yang,et al.  miR-27-3p Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to the Antitumor Agent Olaparib by Targeting PSEN-1, the Catalytic Subunit of Γ-Secretase , 2021, Frontiers in Oncology.

[39]  Wen Xu,et al.  Molecular mechanism of the canonical oncogenic lncRNA MALAT1 in gastric cancer. , 2021, Current medicinal chemistry.

[40]  S. Goswami,et al.  mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification. , 2021, Cardiovascular research.

[41]  Safa Daoud,et al.  Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities , 2021, Molecules.

[42]  Huiwen Ren,et al.  Non-Coding RNA and Diabetic Kidney Disease. , 2021, DNA and cell biology.

[43]  A. Kabakov,et al.  Hypoxia-Induced Cancer Cell Responses Driving Radioresistance of Hypoxic Tumors: Approaches to Targeting and Radiosensitizing , 2021, Cancers.

[44]  Xiaoxin Ma,et al.  Interaction Between LncRNA and UPF1 in Tumors , 2021, Frontiers in Genetics.

[45]  H. Si,et al.  Role of long non-coding RNA H19 in therapy resistance of digestive system cancers , 2021, Molecular medicine.

[46]  Liang Zhao,et al.  LncRNA CRNDE attenuates chemoresistance in gastric cancer via SRSF6-regulated alternative splicing of PICALM , 2021, Molecular Cancer.

[47]  Maite Huarte,et al.  Gene regulation by long non-coding RNAs and its biological functions , 2020, Nature reviews. Molecular cell biology.

[48]  Yu Zhao,et al.  Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine , 2020, Molecular cancer.

[49]  Sha S. Jin,et al.  Long noncoding RNA NEAT1 regulates radio-sensitivity via microRNA-27b-3p in gastric cancer , 2020, Cancer cell international.

[50]  Yingying Gao,et al.  Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM , 2020, British journal of cancer.

[51]  Jincheng Yang,et al.  Down-regulation of lncRNA UCA1 enhances radiosensitivity in prostate cancer by suppressing EIF4G1 expression via sponging miR-331-3p , 2020, Cancer cell international.

[52]  J. Marchal,et al.  CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer , 2020, Cells.

[53]  Peitao Zhou,et al.  ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma , 2020, Journal for immunotherapy of cancer.

[54]  P. Zhou,et al.  DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer , 2020, Signal Transduction and Targeted Therapy.

[55]  Ying-ying Zhang,et al.  Value of long non-coding RNA Rpph1 in esophageal cancer and its effect on cancer cell sensitivity to radiotherapy , 2020, World journal of gastroenterology.

[56]  Bin Liu,et al.  MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer , 2020, Cell Death & Disease.

[57]  A. Melcher,et al.  Inflammatory microenvironment remodelling by tumour cells after radiotherapy , 2020, Nature Reviews Cancer.

[58]  Hong Ge,et al.  Long non-coding RNA HOTAIR knockdown enhances radiosensitivity through regulating microRNA-93/ATG12 axis in colorectal cancer , 2020, Cell Death & Disease.

[59]  Hubing Shi,et al.  Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment , 2020, Frontiers in Oncology.

[60]  J. O’Sullivan,et al.  Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers , 2020, Nature Reviews Gastroenterology & Hepatology.

[61]  R. Tsang,et al.  Radiotherapy in mantle cell lymphoma: A literature review , 2019, Hematological oncology.

[62]  A. Galli,et al.  Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae. , 2019, Mutagenesis.

[63]  Bin Guo,et al.  Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer , 2019, International journal of molecular sciences.

[64]  R. Smolarczyk,et al.  Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy , 2019, International journal of molecular sciences.

[65]  Guan Sun,et al.  Mechanisms and therapeutic potentials of cancer immunotherapy in combination with radiotherapy and/or chemotherapy. , 2019, Cancer letters.

[66]  L. Lv,et al.  Downregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells , 2019, OncoTargets and therapy.

[67]  A. Dubrovska,et al.  Cancer Stem Cells and Radioresistance: DNA Repair and Beyond , 2019, Cancers.

[68]  N. Villegas-Sepúlveda,et al.  New insights into radioresistance in breast cancer identify a dual function of miR‐122 as a tumor suppressor and oncomiR , 2019, Molecular oncology.

[69]  Hui Chen,et al.  Small non‐coding RNA and colorectal cancer , 2019, Journal of cellular and molecular medicine.

[70]  Xin Chen,et al.  Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis , 2018, Cell biology international.

[71]  L. Malatino,et al.  Stroke and Hypertension: An Appraisal from Pathophysiology to Clinical Practice. , 2018, Current vascular pharmacology.

[72]  M. Li,et al.  Inhibition of long non-coding RNA HOTAIR enhances radiosensitivity via regulating autophagy in pancreatic cancer , 2018, Cancer management and research.

[73]  R. Emerson,et al.  Radiotherapy induces responses of lung cancer to CTLA-4 blockade , 2018, Nature Medicine.

[74]  P. Wei,et al.  The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5 , 2018, Journal of Hematology & Oncology.

[75]  Ze Zhang,et al.  FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A , 2018, European journal of pharmacology.

[76]  S. Demaria,et al.  Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect. , 2018, Trends in immunology.

[77]  Wei Liu,et al.  Downregulation of long non‑coding RNA UCA1 enhances the radiosensitivity and inhibits migration via suppression of epithelial‑mesenchymal transition in colorectal cancer cells. , 2018, Oncology reports.

[78]  Wanhu Li,et al.  The LncRNA H19/miR‐193a‐3p axis modifies the radio‐resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1 , 2018, Journal of cellular biochemistry.

[79]  Bing Chen,et al.  Autophagy-regulating microRNAs: potential targets for improving radiotherapy , 2018, Journal of Cancer Research and Clinical Oncology.

[80]  Ying Chen,et al.  Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression. , 2018, Archives of biochemistry and biophysics.

[81]  C. West,et al.  Hypoxia gene expression signatures as predictive biomarkers for personalising radiotherapy. , 2018, The British journal of radiology.

[82]  G. Sun,et al.  Long non-coding RNA NEAT1 regulates the proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p/ROCK1 axis. , 2018, Die Pharmazie.

[83]  E. Ozkan Radiotherapy for Gastrointestinal Stromal Tumors , 2018, Chinese medical journal.

[84]  G. Shivashankar,et al.  Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks , 2017, Nature Cell Biology.

[85]  M. Wu,et al.  Radiotherapy for the treatment of malignant pleural mesothelioma. , 2017, The Lancet. Oncology.

[86]  Ling-Ling Chen,et al.  The Diversity of Long Noncoding RNAs and Their Generation. , 2017, Trends in genetics : TIG.

[87]  M. Dutreix,et al.  Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma , 2017, Radiation Oncology.

[88]  Jian-feng Dong,et al.  Long Noncoding RNA CRNDE/PRC2 Participated in the Radiotherapy Resistance of Human Lung Adenocarcinoma Through Targeting p21 Expression. , 2017, Oncology research.

[89]  Hao Zhu,et al.  LncRNA/DNA binding analysis reveals losses and gains and lineage specificity of genomic imprinting in mammals , 2017, Bioinform..

[90]  Gan Zhang,et al.  The long noncoding RNA‐ROR promotes the resistance of radiotherapy for human colorectal cancer cells by targeting the p53/miR‐145 pathway , 2017, Journal of gastroenterology and hepatology.

[91]  W. Wu,et al.  NEAT1: A novel cancer‐related long non‐coding RNA , 2017, Cell proliferation.

[92]  X. Bai,et al.  The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling , 2017, Molecular Cancer.

[93]  P. Boutros,et al.  Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer , 2016, Oncotarget.

[94]  K. Camphausen,et al.  FOXM1 and STAT3 interaction confers radioresistance in glioblastoma cells , 2016, Oncotarget.

[95]  J. Beermann,et al.  Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. , 2016, Physiological reviews.

[96]  H. Harada Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance , 2016, Journal of radiation research.

[97]  Xu Sun,et al.  Long noncoding RNA NEAT1 is an unfavorable prognostic factor and regulates migration and invasion in gastric cancer , 2016, Journal of Cancer Research and Clinical Oncology.

[98]  Yu Liang,et al.  miR-193a-3p regulation of chemoradiation resistance in oesophageal cancer cells via the PSEN1 gene. , 2016, Gene.

[99]  Q. Lu,et al.  The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma , 2016, Tumor Biology.

[100]  Yingxue Wang,et al.  The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1 , 2016, Tumor Biology.

[101]  Hong Zhang,et al.  Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells. , 2016, International journal of oncology.

[102]  Huan Pang,et al.  Long non‐coding RNA urothelial cancer‐associated 1 promotes bladder cancer cell migration and invasion by way of the hsa‐miR‐145–ZEB1/2–FSCN1 pathway , 2015, Cancer science.

[103]  Jindan Yu,et al.  LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer , 2015, Cell reports.

[104]  A. Vaughan,et al.  CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance , 2015, Molecular Cancer Therapeutics.

[105]  Kevin J. Harrington,et al.  The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence , 2015, Nature Reviews Cancer.

[106]  Ningning Cheng,et al.  Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer , 2015, Oncotarget.

[107]  Y. Shioyama,et al.  Particle radiotherapy for prostate cancer , 2015, International journal of urology : official journal of the Japanese Urological Association.

[108]  Vladimir B. Bajic,et al.  Promoter Analysis Reveals Globally Differential Regulation of Human Long Non-Coding RNA and Protein-Coding Genes , 2014, PloS one.

[109]  K. Morris,et al.  Evolutionary conservation of long non-coding RNAs; sequence, structure, function. , 2014, Biochimica et biophysica acta.

[110]  D. Kambach,et al.  ErbB2, FoxM1 and 14-3-3ζ prime breast cancer cells for invasion in response to ionizing radiation , 2014, Oncogene.

[111]  V. Bajic,et al.  On the classification of long non-coding RNAs , 2013, RNA biology.

[112]  A. Mencalha,et al.  Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line , 2012, PloS one.

[113]  Chen Yang,et al.  Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. , 2012, International journal of oncology.

[114]  F. Pajonk,et al.  Radiation‐Induced Reprogramming of Breast Cancer Cells , 2012, Stem cells.

[115]  P. Drew,et al.  Differential proteomics in the search for biomarkers of radiotherapy resistance , 2011, Expert review of proteomics.

[116]  R. Weichselbaum,et al.  STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect , 2009, BMC medicine.

[117]  N. Foray,et al.  Radiosensibilité intrinsèque et cassures double–brin de l'ADN dans les cellules humaines , 2007 .

[118]  D. Spitz,et al.  Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. , 2007, Cancer research.

[119]  M. Karin Nuclear factor-κB in cancer development and progression , 2006, Nature.

[120]  M. Dewhirst,et al.  Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. , 2004, Cancer cell.

[121]  G. Semenza Signal transduction to hypoxia-inducible factor 1. , 2002, Biochemical pharmacology.

[122]  Naoki Watanabe,et al.  Survivin as a Radioresistance Factor in Pancreatic Cancer , 2000, Japanese journal of cancer research : Gann.

[123]  D. S. St. Clair,et al.  An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta. , 1999, DNA and cell biology.

[124]  Ming Li,et al.  Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer. , 2016, Oncology reports.

[125]  M. Kretz,et al.  Non-coding RNAs: Classification, Biology and Functioning. , 2016, Advances in experimental medicine and biology.

[126]  Ming Sun,et al.  Involvement of lncRNA dysregulation in gastric cancer. , 2016, Histology and histopathology.

[127]  H. Verheul,et al.  Vascular endothelial growth factor and its inhibitors. , 2003, Drugs of today.

[128]  Siyu He,et al.  Arteriosclerosis, Thrombosis , 2022 .