Application of Computer Simulation To Research in the Life Sciences

The paper summarizes guidelines for applying computer simulation to life sciences research. It provides brief answers to the following questions: To what extent can problems be rigorously solved by simu lation—especially complicated problems—and how is this to be done? What can a given simulation study be expected to accomplish, and when can it be considered complete? Of what value are the properties of a model in understanding the living system under study? What should be the proper interaction between simulationists and subject-matter experts in a collaboration? What constitutes ethical conduct for a simulationist? To what extent should the same person do both experiments and simu lation? How should simulationists be trained?

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