THEORY AND PRACTICE OF CONTROLLED DRUG DELIVERY FROM BIOERODIBLE POLYMERS

Drug release from bioerodible polymers is discussed in terms of three dissolution mechanisms. These are (1) watersoluble polymers insolubilized by degradable cross-links, (2) water insoluble polymers solubilized by ionization of pendant groups, and (3) water insoluble polymers solubilized by backbone cleavage.