Synthesis and HIV-1 Integrase Inhibitory Activities of 4-Hydroxy-5-azacoumarin 3-Carboxamides.

Recently, it has been reported that the inhibition of the strand transfer function of HIV-1 integrase is necessaryto obtain significant antiviral activity.Accordingly, several compounds typified by aryl 1,3-diketo acids thatcan inhibit strand transfer reaction of HIV-1 IN have been identified. In this work, we synthesized new 4-hydroxy-5-azacoumarin-3-carbox(thio)amides (