The Effect of the Interaction of Propofol and Alfentanil on Recall, Loss of Consciousness, and the Bispectral Index

The Bispectral Index (BIS) correlates well with the level of consciousness with single anesthetic drugs.We studied the effect of the interaction of propofol with alfentanil on propofol concentration and BIS associated with 50% probability of loss of consciousness and lack of recall (Cp50 and BIS50,

[1]  L. Kearse,et al.  Bispectral Analysis of the Electroencephalogram Predicts Conscious Processing of Information during Propofol Sedation and Hypnosis , 1998, Anesthesiology.

[2]  I. Kissin,et al.  General anesthetic action: an obsolete notion? , 1993, Anesthesia and Analgesia.

[3]  P. Glass,et al.  Evaluation of Pentamorphone in Humans: A New Potent Opiate , 1989, Anesthesia and analgesia.

[4]  J G Reves,et al.  Pharmacokinetic model-driven infusion of fentanyl: assessment of accuracy. , 1990, Anesthesiology.

[5]  K. Leslie,et al.  Propofol Blood Concentration and the Bispectral Index Predict Suppression of Learning During Propofol/Epidural Anesthesia in Volunteers , 1995, Anesthesia and analgesia.

[6]  A. Burm,et al.  Pharmacodynamics of propofol in female patients. , 1992, Anesthesiology.

[7]  J. Antognini,et al.  Exaggerated Anesthetic Requirements in the Preferentially Anesthetized Brain , 1993, Anesthesiology.

[8]  I J Rampil,et al.  Anesthetic Potency (MAC) Is Independent of Forebrain Structures in the Rat , 1993, Anesthesiology.

[9]  Warren D. Smith,et al.  Measuring the Performance of Anesthetic Depth Indicators , 1996, Anesthesiology.

[10]  P. Glass,et al.  Anesthetic drug interactions: an insight into general anesthesia--its mechanism and dosing strategies. , 1998, Anesthesiology.

[11]  A. Borgeat,et al.  Analgesia with subhypnotic doses of thiopentone and propofol. , 1991, British journal of anaesthesia.

[12]  A. McEwan,et al.  The Interaction of Fentanyl on the Cp50 of Propofol for Loss of Consciousness and Skin Incision , 1994, Anesthesiology.

[13]  L. Kearse,et al.  Bispectral Analysis of the Electroencephalogram Correlates with Patient Movement to Skin Incision during Propofol/Nitrous Oxide Anesthesia , 1994, Anesthesiology.

[14]  D R Stanski,et al.  Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. , 1987, The Journal of pharmacology and experimental therapeutics.

[15]  J G Bovill,et al.  The Pharmacodynamic Interaction of Propofol and Alfentanil during Lower Abdominal Surgery in Women , 1995, Anesthesiology.

[16]  V A Feshchenko,et al.  The Comparative Amnestic Effects of Midazolam, Propofol, Thiopental, and Fentanyl at Equisedative Concentrations , 1997, Anesthesiology.

[17]  N. T. Smith,et al.  A Multicenter Study of Bispectral Electroencephalogram Analysis for Monitoring Anesthetic Effect , 1997, Anesthesia and analgesia.

[18]  P. Hartvig,et al.  Concentration‐Effect Relationships of Propofol After Total Intravenous Anesthesia , 1993, Anesthesia and analgesia.

[19]  Peter S. Sebel,et al.  Bispectral Analysis Measures Sedation and Memory Effects of Propofol, Midazolam, Isoflurane, and Alfentanil in Healthy Volunteers , 1997, Anesthesiology.

[20]  E. Gepts,et al.  Disposition of Propofol Administered as Constant Rate Intravenous Infusions in Humans , 1987, Anesthesia and analgesia.

[21]  Paul F. White,et al.  Electroencephalogram bispectral analysis predicts the depth of midazolam-induced sedation. , 1996 .