STARD4 abundance regulates sterol transport and sensing

The expression of a small sterol transport protein, STARD4, is regulated by cholesterol levels. We show that the abundance of STARD4 regulates the sensitivity of the SREBP-2 system to changes in cholesterol, providing an additional layer of regulation in the cholesterol homeostatic mechanism.

[1]  E. Ikonen,et al.  Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells , 2011, Traffic.

[2]  W. Prinz,et al.  The diverse functions of oxysterol-binding proteins. , 2010, Annual review of cell and developmental biology.

[3]  Kai Simons,et al.  Revitalizing membrane rafts: new tools and insights , 2010, Nature Reviews Molecular Cell Biology.

[4]  F. Maxfield,et al.  Cholesterol, the central lipid of mammalian cells. , 2010, Current opinion in cell biology.

[5]  S. Grinstein,et al.  The distribution and function of phosphatidylserine in cellular membranes. , 2010, Annual review of biophysics.

[6]  Marc P. Waase,et al.  Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism[S] , 2010, Journal of Lipid Research.

[7]  F. Maxfield,et al.  Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells , 2010, Proceedings of the National Academy of Sciences.

[8]  G. Schmitz,et al.  Fluorescent high‐content imaging allows the discrimination and quantitation of E‐LDL‐induced lipid droplets and Ox‐LDL‐generated phospholipidosis in human macrophages , 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[9]  R. Ghirlando,et al.  Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues , 2009, The Journal of cell biology.

[10]  F. Maxfield,et al.  Intracellular sterol dynamics. , 2009, Biochimica et biophysica acta.

[11]  Robert V Farese,et al.  Lipid droplets at a glance , 2009, Journal of Cell Science.

[12]  J. McDonald,et al.  Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance. , 2008, Cell metabolism.

[13]  T. Steck,et al.  Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol. , 2008, Progress in lipid research.

[14]  Elina Ikonen,et al.  Cellular cholesterol trafficking and compartmentalization , 2008, Nature Reviews Molecular Cell Biology.

[15]  G. Meer,et al.  Membrane lipids: where they are and how they behave , 2008, Nature Reviews Molecular Cell Biology.

[16]  W. Prinz.  Non-vesicular sterol transport in cells. , 2007, Progress in lipid research.

[17]  W. Miller.  Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. , 2007, Biochimica et biophysica acta.

[18]  F. Maxfield,et al.  Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. , 2007, Molecular biology of the cell.

[19]  G. Fairn,et al.  Emerging roles of the oxysterol-binding protein family in metabolism, transport, and signaling , 2007, Cellular and Molecular Life Sciences.

[20]  B. Roux,et al.  Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol1s⃞ Published, JLR Papers in Press, September 21, 2006. , 2006, Journal of Lipid Research.

[21]  F. Maxfield,et al.  Intracellular sterol transport and distribution. , 2006, Current opinion in cell biology.

[22]  C. T. Beh,et al.  Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast. , 2006, Biochemical Society transactions.

[23]  F. Maxfield,et al.  Sterol and lipid trafficking in mammalian cells. , 2006, Biochemical Society transactions.

[24]  J. Hurley,et al.  Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein–related proteins and phosphoinositides , 2006, The Journal of cell biology.

[25]  F. Maxfield,et al.  Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells Published, JLR Papers in Press, November 15, 2005. , 2006, Journal of Lipid Research.

[26]  C. Tomasetto,et al.  Give lipids a START: the StAR-related lipid transfer (START) domain in mammals , 2005, Journal of Cell Science.

[27]  Rachel M. Adams,et al.  Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins , 2005, Journal of Biological Chemistry.

[28]  A. Menon,et al.  Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. , 2005, Biochemistry.

[29]  G. van Meer,et al.  Membrane lipids and vesicular traffic. , 2004, Current opinion in cell biology.

[30]  N. Carrasco,et al.  Advances in Na+/I− symporter (NIS) research in the thyroid and beyond , 2003, Molecular and Cellular Endocrinology.

[31]  Jay D. Horton,et al.  Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[32]  J. Breslow,et al.  StAR-related Lipid Transfer (START) Proteins: Mediators of Intracellular Lipid Metabolism* , 2003, Journal of Biological Chemistry.

[33]  J. Strauss,et al.  START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells , 2003, Molecular and Cellular Endocrinology.

[34]  V. Olkkonen,et al.  The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling. , 2003, Biochimica et biophysica acta.

[35]  D. Wüstner,et al.  Rapid transbilayer movement of the fluorescent sterol dehydroergosterol in lipid membranes. , 2002, Biophysical journal.

[36]  Stephen K. Burley,et al.  Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[37]  F. Maxfield,et al.  Vesicular and Non-vesicular Sterol Transport in Living Cells , 2002, The Journal of Biological Chemistry.

[38]  A. Dierich,et al.  The Steroidogenic Acute Regulatory Protein Homolog MLN64, a Late Endosomal Cholesterol-binding Protein* , 2001, The Journal of Biological Chemistry.

[39]  P. Espenshade,et al.  Regulated Step in Cholesterol Feedback Localized to Budding of SCAP from ER Membranes , 2000, Cell.

[40]  E. Ikonen,et al.  Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Hurley,et al.  Structure and lipid transport mechanism of a StAR-related domain , 2000, Nature Structural Biology.

[42]  T. Steck,et al.  Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. , 1999, Journal of lipid research.

[43]  K. Caron,et al.  Targeted disruption of StAR provides novel insights into congenital adrenal hyperplasia. , 1998, Endocrine research.

[44]  R. D. Simoni,et al.  Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane. , 1990, The Journal of biological chemistry.

[45]  W. Rosoff,et al.  Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate. , 1988, The Journal of biological chemistry.

[46]  F. Maxfield,et al.  Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptor , 1987, The Journal of cell biology.

[47]  M. Brown,et al.  Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. , 1983, Methods in enzymology.