A rare case of topical methazolamide ophthalmic solution causing death due to toxic epidermal necrolysis

plasm, primarily affects the apocrine-rich anogenital skin. EMPD can be divided into primary and secondary EMPD, depending on the underlying apocrine carcinoma, adjacent malignancy, distant carcinoma and immunohistochemistry. In our case, the tumour cells were positive for CD7 and negative for CK20 and GCDFP-15, and no clear signs of tumour metastasis were found during hospitalization. Thus, primary EMPD was diagnosed. The relationship between PH and neoplasia is unclear, because of the lack of available research and the variety of immunological profiles among affected patients. Paraneoplastic pemphigus (PNP) is typically defined as an autoimmune blistering disease associated with underlying neoplasia. Palleschi and Giomi proposed a diagnosis of ‘paraneoplastic pemphigus herpetiformis’ that may be used to describe the coexistence of PH and neoplasia and may belong to a wider definition of PNP. Additionally, Gallo et al. described a patient with PNP who presented with eosinophilic spongiosis; this may further strengthen the link between PH and PNP. Further research on PH is needed to explore the relationship between PH and neoplasia. Our case may expand the knowledge base regarding the association between these two conditions.