A comprehensive assessment of cognitive function in the common genetic generalized epilepsy syndromes

Considered to be benign conditions, the common genetic generalized epilepsy (GGE) syndromes are now known to be frequently accompanied by cognitive dysfunction. However, unresolved issues impede clinical management of this common comorbidity, including which cognitive abilities are most affected, whether there are differences between syndromes and how seizure type and mood symptoms affect cognitive dysfunction. We provide a detailed description of cognitive ability and evaluate factors contributing to cognitive dysfunction.

[1]  E. Andermann,et al.  Familial Association of Neuropsychological Traits in Patients With Generalized and Partial Seizure Disorders , 2002, Journal of clinical and experimental neuropsychology.

[2]  J. H. Cross,et al.  Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 , 2010, Epilepsia.

[3]  P. Camfield,et al.  Idiopathic generalized epilepsy with generalized tonic-clonic seizures (IGE-GTC): A population-based cohort with >20year follow up for medical and social outcome , 2010, Epilepsy & Behavior.

[4]  G. B. Young,et al.  Do nonconvulsive seizures damage the brain?--Yes. , 1998, Archives of neurology.

[5]  Maryse Lassonde,et al.  Idiopathic epileptic syndromes and cognition , 2006, Neuroscience & Biobehavioral Reviews.

[6]  K. McGrew,et al.  The relationship between intra-cognitive scatter on the Woodcock-Johnson Psycho-Educational Battery-Revised and school achievement , 1996 .

[7]  O. Devinsky,et al.  Adult‐Onset Idiopathic Generalized Epilepsy: Clinical and Behavioral Features , 2001, Epilepsia.

[8]  W. D’Souza,et al.  Cognitive functioning in idiopathic generalised epilepsies: A systematic review and meta-analysis , 2014, Neuroscience & Biobehavioral Reviews.

[9]  M. Cook,et al.  Atypical EEG abnormalities in genetic generalized epilepsies , 2016, Clinical Neurophysiology.

[10]  M. Koutroumanidis,et al.  Psychiatric comorbidity in adult patients with idiopathic generalized epilepsy , 2008, Epilepsy & Behavior.

[11]  Suresh Gurbani,et al.  Childhood absence epilepsy: Behavioral, cognitive, and linguistic comorbidities , 2008, Epilepsia.

[12]  W. Sturm,et al.  Neuropsychological assessment , 2007, Journal of Neurology.

[13]  David J. Therriault,et al.  A latent variable analysis of working memory capacity, short-term memory capacity, processing speed, and general fluid intelligence , 2002 .

[14]  Randall W Engle,et al.  Working memory, short-term memory, and general fluid intelligence: a latent-variable approach. , 1999, Journal of experimental psychology. General.

[15]  D. Mandelbaum,et al.  Baseline cognition, behavior, and motor skills in children with new‐onset, idiopathic epilepsy , 2010, Developmental medicine and child neurology.

[16]  M. Aminoff.  Do nonconvulsive seizures damage the brain?--No. , 1998, Archives of neurology.

[17]  Pierre Jallon,et al.  Epidemiology of Idiopathic Generalized Epilepsies , 2005, Epilepsia.

[18]  Paul A. Jewsbury,et al.  Integrating the switching, inhibition, and updating model of executive function with the Cattell-Horn-Carroll model. , 2016, Journal of experimental psychology. General.

[19]  J. Sattler,et al.  Assessment of Children: Behavioral and Clinical Applications , 2001 .

[20]  Bruce Hermann,et al.  The impact of epilepsy from the patient’s perspective I. Descriptions and subjective perceptions , 2000, Epilepsy Research.

[21]  W. D’Souza,et al.  A Systematic Review of Psychiatric and Psychosocial Comorbidities of Genetic Generalised Epilepsies (GGE) , 2016, Neuropsychology Review.

[22]  Matthew N. DeSalvo,et al.  Differentiation of attention-related problems in childhood absence epilepsy , 2010, Epilepsy & Behavior.

[23]  Klaus P. Ebmeier,et al.  A meta-analysis of depression severity and cognitive function. , 2009, Journal of affective disorders.

[24]  R. Mattson,et al.  Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. , 1989, Epilepsia.

[25]  E. Mizrahi,et al.  Pretreatment EEG in childhood absence epilepsy , 2013, Neurology.

[26]  R. Press,et al.  Proposal for Revised Clinical and ~lectro~nce~halo ~ra~hic Classification of Epileptic Seizures From the Commission on Classification and Terminology of the International League Against Epilepsy* , 1981 .

[27]  J. Duncan,et al.  Cognitive Decline in Severe Intractable Epilepsy , 2005, Epilepsia.

[28]  D. Bergen.  Do Seizures Harm the Brain? , 2006, Epilepsy currents.

[29]  Paul A. Jewsbury,et al.  The Cattell–Horn–Carroll Model of Cognition for Clinical Assessment , 2017 .