Improving the feeder shoe design of an eccentric tablet press machine

Abstract In this work, a DEM model is used to analyze the segregation mechanisms during the operation of an eccentric tablet press machine with the objective of reducing them by using inserts in the feeder shoe. In order to validate the DEM model, nine simulations combining three mixtures and three feeder shoe designs were conducted and their results were compared to experimental data. These nine simulations also allowed to determine the feeder shoe designs that segregate all of the mixtures least and which of the mixtures segregates more than the other mixtures, whatever the feeder shoe was used. Additional simulations were conducted to modify the geometry of all the feeder shoe designs by the inclusion of sixteen inserts. By conducting these simulations, it was possible to reduce the SI for all the configurations that combined the mixtures and the feeder shoe designs, attaining a reduction of 51% for one of them.

[1]  Chunlei Pei,et al.  Modelling die filling with charged particles using DEM/CFD , 2012 .

[2]  Srikanth R. Gopireddy,et al.  Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach , 2019, Powder Technology.

[3]  Srikanth R. Gopireddy,et al.  Simulation of particle size segregation in a pharmaceutical tablet press lab-scale gravity feeder , 2017 .

[4]  Rafael Méndez,et al.  Microdynamic analysis of particle flow in a confined space using DEM: The feed frame case , 2016 .

[5]  Rafael Méndez,et al.  Relationship between residence time distribution and forces applied by paddles on powder attrition during the die filling process , 2015 .

[6]  Colin Thornton,et al.  Numerical analysis of density-induced segregation during die filling , 2010 .

[7]  Colin Thornton,et al.  3D DEM/CFD analysis of size-induced segregation during die filling , 2011 .

[8]  Srikanth R. Gopireddy,et al.  Numerical Analysis of the Die Filling Process Within a Pharmaceutical Tableting Machine , 2018 .

[9]  Jiang Binbo,et al.  Multi-scale study of particle flow in silos , 2009 .

[10]  Bodhisattwa Chaudhuri,et al.  DEM based computational model to predict moisture induced cohesion in pharmaceutical powders. , 2018, International journal of pharmaceutics.

[11]  Joaquín B. Ordieres Meré,et al.  Segregation in the tank of a rotary tablet press machine using experimental and discrete element methods , 2018 .

[12]  V. Vanhoorne,et al.  Optimizing feed frame design and tableting process parameters to increase die‐filling uniformity on a high‐speed rotary tablet press , 2018, International journal of pharmaceutics.

[13]  Henrik Saxén,et al.  Experimental and DEM study of segregation of ternary size particles in a blast furnace top bunker model , 2010 .

[14]  Shengli Wu,et al.  DEM simulation of particle size segregation behavior during charging into and discharging from a Paul-Wurth type hopper , 2013 .

[15]  Arno Kwade,et al.  Segregation in heaps and silos: Comparison between experiment, simulation and continuum model , 2016 .

[16]  William R. Ketterhagen,et al.  Simulation of powder flow in a lab-scale tablet press feed frame: Effects of design and operating parameters on measures of tablet quality , 2015 .

[17]  G. G. Enstad Segregation of powders - mechanisms, processes and counteraction , 2001 .

[18]  Rafael Méndez,et al.  Particle size segregation promoted by powder flow in confined space: The die filling process case , 2014 .

[19]  Colin Thornton,et al.  The effects of air and particle density difference on segregation of powder mixtures during die filling , 2011 .

[20]  J. Beddow,et al.  Powder segregation during die filling , 1969 .

[21]  Shu-San Hsiau,et al.  Segregation to mixing in wet granular matter under vibration , 2010 .

[22]  Bruno C. Hancock,et al.  Granular segregation in discharging cylindrical hoppers: A discrete element and experimental study , 2007 .

[23]  Shayne C. Gad,et al.  Pharmaceutical manufacturing handbook : production and processes , 2008 .

[24]  Srikanth R. Gopireddy,et al.  Investigation of powder flow within a pharmaceutical tablet press force feeder – A DEM approach , 2019, Powder Technology.

[25]  Angel Garcimartín,et al.  Flow and clogging in a silo with an obstacle above the orifice. , 2012, Physical review. E, Statistical, nonlinear, and soft matter physics.

[26]  Andrea C. Santomaso,et al.  Prediction of segregation in funnel and mass flow discharge , 2016 .

[27]  Niklas Sandler,et al.  Determination of segregation tendency of granules using surface imaging. , 2012, Journal of pharmaceutical sciences.

[28]  Tom Dyakowski,et al.  Flow of sphero-disc particles in rectangular hoppers - A DEM and experimental comparison in 3D , 2004 .

[29]  Jennifer S. Curtis,et al.  Modeling granular segregation in flow from quasi-three-dimensional, wedge-shaped hoppers , 2008 .

[30]  Angel Garcimartín,et al.  Silo clogging reduction by the presence of an obstacle. , 2011, Physical review letters.

[31]  Bruno C. Hancock,et al.  Optimizing the design of eccentric feed hoppers for tablet presses using DEM , 2010, Comput. Chem. Eng..

[32]  Xiaosong Sun,et al.  Numerical investigation on the influence of air flow in a die filling process , 2017, Journal of the Taiwan Institute of Chemical Engineers.

[33]  Keisuke Takagaki,et al.  Size-induced segregation during pharmaceutical particle die filling assessed by response surface methodology using discrete element method , 2016 .

[34]  Srikanth R. Gopireddy,et al.  Numerical simulation of powder flow in a pharmaceutical tablet press lab-scale gravity feeder , 2016 .

[35]  Yusuke Shigeto,et al.  Numerical simulation of industrial die filling using the discrete element method , 2015 .