Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages

[1]  Binghua Liu,et al.  DNA methylation in promoter region of immune related genes STAT3 and VEGF and biochemical parameters change in muscle of Japanese flounder under acute hypoxia. , 2021, Developmental and comparative immunology.

[2]  Ping Yang,et al.  MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program , 2020, Science Advances.

[3]  Guangdi Li,et al.  DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice , 2020, Nature Communications.

[4]  Tin-Lap Lee,et al.  Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition , 2020, Proceedings of the National Academy of Sciences.

[5]  T. Muthukumar,et al.  Mitophagy dependent macrophage reprogramming protects against kidney fibrosis. , 2019, JCI insight.

[6]  J. Privratsky,et al.  KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. , 2019, Journal of the American Society of Nephrology : JASN.

[7]  O. Pabst,et al.  Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine , 2019, Nature Communications.

[8]  Lei Dong,et al.  CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis. , 2019, Kidney international.

[9]  H. Lan,et al.  Macrophages: versatile players in renal inflammation and fibrosis , 2019, Nature Reviews Nephrology.

[10]  Dongshan Zhang,et al.  Atg7 mediates renal tubular cell apoptosis in vancomycin nephrotoxicity through activation of PKC‐δ , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  Xiao-ming Meng,et al.  Macrophages in Renal Fibrosis. , 2019, Advances in experimental medicine and biology.

[12]  Xiaodong Han,et al.  M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis , 2018, Cell Communication and Signaling.

[13]  Jessica M. Overstreet,et al.  TGF-β promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration. , 2018, JCI insight.

[14]  X. Xiang,et al.  MBD2‐mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression , 2018, Experimental cell research.

[15]  Z. Dong,et al.  MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI , 2017, Cell Death & Disease.

[16]  Xiaodong Han,et al.  M2 macrophages induce EMT through the TGF‐β/Smad2 signaling pathway , 2017, Cell biology international.

[17]  Xiao-Ming Yin,et al.  Protein Kinase Cδ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity. , 2017, Journal of the American Society of Nephrology : JASN.

[18]  D. Zheng,et al.  Transcriptome analysis of microglia in a mouse model of Rett syndrome: differential expression of genes associated with microglia/macrophage activation and cellular stress , 2017, Molecular Autism.

[19]  Z. Dong,et al.  p53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO , 2017, Scientific Reports.

[20]  H. Aramaki,et al.  Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease , 2016, EBioMedicine.

[21]  Zhaolan Zhou,et al.  Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation , 2016, Front. Genet..

[22]  A. Bird,et al.  A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells , 2015, Nature Communications.

[23]  Steffen Jung,et al.  Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. , 2015, Immunity.

[24]  Z. Dong,et al.  Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling , 2015, Drug design, development and therapy.

[25]  L. Wen,et al.  MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis. , 2014, Journal of autoimmunity.

[26]  M. Szyf,et al.  Methylated DNA Binding Domain Protein 2 (MBD2) Coordinately Silences Gene Expression through Activation of the MicroRNA hsa-mir-496 Promoter in Breast Cancer Cell Line , 2013, PloS one.

[27]  P. Taylor,et al.  Distinct bone marrow-derived and tissue resident macrophage-lineages proliferate at key stages during inflammation , 2013, Nature Communications.

[28]  Z. Dong,et al.  Paclitaxel Ameliorates Lipopolysaccharide-Induced Kidney Injury by Binding Myeloid Differentiation Protein-2 to Block Toll-Like Receptor 4–Mediated Nuclear Factor-κB Activation and Cytokine Production , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[29]  G. Ling,et al.  Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192 , 2011, The Journal of pathology.

[30]  H. Rabb,et al.  Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury. , 2011, Journal of the American Society of Nephrology : JASN.

[31]  R. Kalluri,et al.  Methylation determines fibroblast activation and fibrogenesis in the kidney , 2010, Nature Medicine.

[32]  G. Ling,et al.  Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-β/Smad activity , 2010, Laboratory Investigation.

[33]  D. Takai,et al.  Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists. , 2009, Biochemical and biophysical research communications.

[34]  B. Thornhill,et al.  Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. , 2009, Kidney international.

[35]  O. Sansom,et al.  Mechanisms of Disease: methyl-binding domain proteins as potential therapeutic targets in cancer , 2007, Nature Clinical Practice Oncology.

[36]  R. Colvin,et al.  Phenotypic and Functional Characterization of Kidney-Infiltrating Lymphocytes in Renal Ischemia Reperfusion Injury1 , 2006, The Journal of Immunology.

[37]  M. Rehli,et al.  Functional Analysis of Promoter CPG-Methylation using a CpG-Free Luciferase Reporter Vector , 2006, Epigenetics.

[38]  M. Nangaku.  Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure. , 2004, Internal medicine.

[39]  A. Bird,et al.  Deficiency of Mbd2 suppresses intestinal tumorigenesis , 2003, Nature Genetics.