论文信息 - The prevalence of coeliac disease in Down's syndrome in Malta

The prevalence of coeliac disease in Down's syndrome in Malta

Abstract The prevalence of coeliac disease is increased in individuals with Down's syndrome. The objective of this study was to assess the frequency of coeliac disease in Down's syndrome in Malta. One hundred children and adults with Down's were screened for coeliac disease. A history was taken from all of them and they were examined and measured for weight and height. A full blood count, antigliadin (IgG and IgA) and anti-endomysial antibodies were estimated. Equivocal cases were also screened for antireticulin antibodies. Jejunal biopsy was recommended in all serologically positive cases. The frequency of coeliac disease in Down's syndrome was 8%, much greater than that in the general population. Screening for coeliac disease in all cases of Down's syndrome is therefore recommended.

V. Grech | C. Vella | Christopher Sciberras

[1] D. Metzger,et al. High prevalence of celiac disease in patients with type 1 diabetes detected by antibodies to endomysium and tissue transglutaminase. , 2001, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[2] H. Freeman. Small intestinal mucosal biopsy for investigation of diarrhea and malabsorption in adults. , 2000, Gastrointestinal endoscopy clinics of North America.

[3] A. Bredberg,et al. Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome. , 1998, Pediatrics.

[4] H. Freeman. Neoplastic Disorders in 100 Patients with Adult Celiac Disease , 1996 .

[5] M. Digilio,et al. Down's Syndrome and Celiac Disease: The Prevalence of High IgA‐Antigliadin Antibodies and HLA‐DR and DQ Antigens in Trisomy 21 , 1993, Journal of pediatric gastroenterology and nutrition.