History and Original Thoughts on the Control Theoretic Approach

I have been asked to present some historical background on the early theory of metabolic control; I am pleased to do so. I guess I was asked to do this because to some, at least, I am considered a grandfather of the field. I am not sure how I came to be a grandfather without ever being a father. Yet let that be, for I accept the accolade with sincere appreciation even though I think it partly, if not wholly, apocryphal. But if there are grandfathers, there must also be great-grandfathers and even great-great-grandfathers lurking in the woods. So with no small concern about the validity of such terms, I shall nevertheless address this history in those terms. Hopefully some grandchildren will be reading too. But let me note at the outset that I am not a scientific historian and that I present this history from a rather personal view.

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