Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.

[1]  C. Piantadosi,et al.  The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. , 2015, American journal of respiratory cell and molecular biology.

[2]  D. Dexter,et al.  Neurodegenerative diseases and therapeutic strategies using iron chelators. , 2015, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

[3]  Jong-Seok Moon,et al.  Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. , 2015, American journal of physiology. Lung cellular and molecular physiology.

[4]  S. Tanguy,et al.  Carbon monoxide increases inducible NOS expression that mediates CO-induced myocardial damage during ischemia-reperfusion. , 2015, American journal of physiology. Heart and circulatory physiology.

[5]  H. Hartung,et al.  Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety , 2015, Expert review of neurotherapeutics.

[6]  U. Schatzschneider Novel lead structures and activation mechanisms for CO‐releasing molecules (CORMs) , 2015, British journal of pharmacology.

[7]  Haifa Hamdi,et al.  Micro‐RNA‐155‐mediated control of heme oxygenase 1 (HO‐1) is required for restoring adaptively tolerant CD4+ T‐cell function in rodents , 2015, European journal of immunology.

[8]  D. Babu,et al.  CO and CO‐releasing molecules (CO‐RMs) in acute gastrointestinal inflammation , 2015, British journal of pharmacology.

[9]  Chengbao Wang,et al.  MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression , 2015, Journal of Virology.

[10]  S. Ryter,et al.  IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production , 2015, Cellular and Molecular Immunology.

[11]  C. Gieger,et al.  Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism Is Associated With Progressive Atherosclerosis and Incident Cardiovascular Disease , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[12]  R. Zhu,et al.  Heme Oxygenase-1 Restores Impaired GARP+CD4+CD25+ Regulatory T Cells from Patients with Acute Coronary Syndrome by Upregulating LAP and GARP Expression on Activated T Lymphocytes , 2015, Cellular Physiology and Biochemistry.

[13]  Y. Naito,et al.  Heme oxygenase-1 and anti-inflammatory M2 macrophages. , 2014, Archives of biochemistry and biophysics.

[14]  M. Won,et al.  Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. , 2014, Antioxidants & redox signaling.

[15]  E. van Rooij,et al.  MicroRNA-24 antagonism prevents renal ischemia reperfusion injury. , 2014, Journal of the American Society of Nephrology : JASN.

[16]  R. Poole,et al.  Interaction of the carbon monoxide-releasing molecule Ru(CO)3Cl(glycinate) (CORM-3) with Salmonella enterica serovar Typhimurium: in situ measurements of carbon monoxide binding by integrating cavity dual-beam spectrophotometry. , 2014, Microbiology.

[17]  D. Ingram,et al.  Neurotherapeutic effects of novel HO‐1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease , 2014, Journal of neurochemistry.

[18]  R. Yu,et al.  Induction of Heme Oxygenase-1 with Hemin Reduces Obesity-Induced Adipose Tissue Inflammation via Adipose Macrophage Phenotype Switching , 2014, Mediators of inflammation.

[19]  R. Flavell,et al.  Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. , 2014, The Journal of clinical investigation.

[20]  M. Rivard,et al.  Design and synthesis of new hybrid molecules that activate the transcription factor Nrf2 and simultaneously release carbon monoxide. , 2014, Chemistry.

[21]  D. Tarng,et al.  Length polymorphism in heme oxygenase-1 and risk of CKD among patients with coronary artery disease. , 2014, Journal of the American Society of Nephrology : JASN.

[22]  S. Ryter,et al.  Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways , 2014, Innate immunity.

[23]  A. Gulbinas,et al.  Heme Oxygenase-1 Gene Promoter Polymorphism Is Associated With the Development of Necrotizing Acute Pancreatitis , 2014, Pancreas.

[24]  E. Gumienna-Kontecka,et al.  Iron chelating strategies in systemic metal overload, neurodegeneration and cancer. , 2014, Current medicinal chemistry.

[25]  P. Pástor,et al.  An association study between Heme oxygenase-1 genetic variants and Parkinson's disease , 2014, Front. Cell. Neurosci..

[26]  Gelin Xu,et al.  Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke , 2014, Journal of the Neurological Sciences.

[27]  Hyung Gyun Kim,et al.  Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. , 2014, Free radical biology & medicine.

[28]  M. Madonia,et al.  The role of the heme oxygenase system in the metabolic syndrome. , 2014, Current pharmaceutical design.

[29]  C. Ki,et al.  HMOX1 Gene Promoter Polymorphism is Not Associated with Coronary Artery Disease in Koreans , 2014, Annals of laboratory medicine.

[30]  D. Hilfiker-Kleiner,et al.  Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization. , 2014, Antioxidants & redox signaling.

[31]  M. Racke,et al.  Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate , 2014, Drug design, development and therapy.

[32]  O. Wagner,et al.  Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man , 2014, Cell.

[33]  J. Kere,et al.  Microsatellite Polymorphism in the Heme Oxygenase-1 Promoter Is Associated With Nonsevere and Late-Onset Preeclampsia , 2014, Hypertension.

[34]  In-kyu Lee,et al.  Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms , 2014, Redox biology.

[35]  R. Poole,et al.  Introducing [Mn(CO)3(tpa-κ(3)N)](+) as a novel photoactivatable CO-releasing molecule with well-defined iCORM intermediates - synthesis, spectroscopy, and antibacterial activity. , 2014, Dalton transactions.

[36]  B. Yard,et al.  New modular manganese(I) tricarbonyl complexes as PhotoCORMs: in vitro detection of photoinduced carbon monoxide release using COP-1 as a fluorogenic switch-on probe. , 2014, Dalton transactions.

[37]  Kecheng Zhang,et al.  MiR-204/miR-211 downregulation contributes to candidemia-induced kidney injuries via derepression of Hmx1 expression. , 2014, Life sciences.

[38]  Shangha Pan,et al.  Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1. , 2014, International immunopharmacology.

[39]  P. Dennery Signaling function of heme oxygenase proteins. , 2014, Antioxidants & redox signaling.

[40]  A. Józkowicz,et al.  Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs. , 2014, Antioxidants & redox signaling.

[41]  R. Foresti,et al.  Heme oxygenase-1 as a target for drug discovery. , 2014, Antioxidants & redox signaling.

[42]  Hideaki Sato,et al.  Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase , 2014, Proceedings of the National Academy of Sciences.

[43]  M. Wolzt,et al.  Human Pharmacokinetics of High Dose Oral Curcumin and Its Effect on Heme Oxygenase-1 Expression in Healthy Male Subjects , 2014, BioMed research international.

[44]  A. Alayash,et al.  Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. , 2014, Blood.

[45]  S. Ryter,et al.  Carbon monoxide confers protection in sepsis by enhancing beclin 1-dependent autophagy and phagocytosis. , 2014, Antioxidants & redox signaling.

[46]  L. Otterbein,et al.  Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. , 2014, Endocrinology.

[47]  O. Moine,et al.  Microsatellite polymorphism in the heme oxygenase‐1 gene promoter is not associated with alcoholic liver disease severity , 2014, Hepatology.

[48]  L. M. Saraiva,et al.  The Bactericidal Activity of Carbon Monoxide–Releasing Molecules against Helicobacter pylori , 2013, PloS one.

[49]  S. Kim,et al.  NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1. , 2013, Free radical biology & medicine.

[50]  S. Remy,et al.  Carbon monoxide decreases endosome–lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells. , 2013, European journal of immunology.

[51]  S. Ryter,et al.  Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells , 2013, Oxidative medicine and cellular longevity.

[52]  G. Vercellotti,et al.  MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice. , 2013, Blood.

[53]  K. Huse,et al.  Alternative 5’ Untranslated Regions Are Involved in Expression Regulation of Human Heme Oxygenase-1 , 2013, PloS one.

[54]  J. Dubois-Randé,et al.  Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. , 2013, Pharmacological research.

[55]  R. Siow,et al.  Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis. , 2013, Free radical biology & medicine.

[56]  R. Poole,et al.  Ru(CO)3Cl(Glycinate) (CORM-3): a carbon monoxide-releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. , 2013, Antioxidants & redox signaling.

[57]  M. Cieśla,et al.  Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis. , 2013, Antioxidants & redox signaling.

[58]  Ashok Kumar,et al.  Heme oxygenase-1 gene variants and hyperbilirubinemia risk in North Indian newborns , 2013, European Journal of Pediatrics.

[59]  Patty J. Lee,et al.  Lung endothelial HO‐1 targeting in vivo using lentiviral miRNA regulates apoptosis and autophagy during oxidant injury , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[60]  S. Prabhu,et al.  Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase , 2013, Laboratory Investigation.

[61]  D. Stec,et al.  Chronic Carbon Monoxide Treatment Attenuates Development of Obesity and Remodels Adipocytes in Mice Fed a High Fat Diet , 2013, International Journal of Obesity.

[62]  S. Plevy,et al.  Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. , 2013, Gastroenterology.

[63]  L. Silengo,et al.  Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases , 2013, Circulation.

[64]  G. Rimbach,et al.  Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells. , 2013, Molecular nutrition & food research.

[65]  P. Buehler,et al.  Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. , 2013, Blood.

[66]  L. Chau,et al.  Adipose Overexpression of Heme Oxygenase-1 Does Not Protect against High Fat Diet-Induced Insulin Resistance in Mice , 2013, PloS one.

[67]  R. Foresti,et al.  Vasorelaxing effects and inhibition of nitric oxide in macrophages by new iron-containing carbon monoxide-releasing molecules (CO-RMs). , 2013, Pharmacological research.

[68]  G. Li Volti,et al.  Potential therapeutic effects of natural heme oxygenase-1 inducers in cardiovascular diseases. , 2013, Antioxidants & redox signaling.

[69]  Z. Jia,et al.  Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds , 2013, Journal of The Royal Society Interface.

[70]  S. Remy,et al.  Carbon monoxide‐treated dendritic cells decrease β1‐integrin induction on CD8+ T cells and protect from type 1 diabetes , 2013, European Journal of Immunology.

[71]  L. Mahimainathan,et al.  Identification of Novel microRNAs in Post-Transcriptional Control of Nrf2 Expression and Redox Homeostasis in Neuronal, SH-SY5Y Cells , 2012, PloS one.

[72]  R. Foresti,et al.  Emerging concepts on the anti-inflammatory actions of carbon monoxide-releasing molecules (CO-RMs) , 2012, Medical gas research.

[73]  Qing Tian,et al.  The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes. , 2012, Biochimica et biophysica acta.

[74]  H. Vali,et al.  Unregulated brain iron deposition in transgenic mice over‐expressing HMOX1 in the astrocytic compartment , 2012, Journal of neurochemistry.

[75]  R. Muniyappa,et al.  Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α. , 2012, The Journal of nutritional biochemistry.

[76]  Takafumi Suzuki,et al.  Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. , 2012, Free radical biology & medicine.

[77]  Masaaki Komatsu,et al.  Keap1 degradation by autophagy for the maintenance of redox homeostasis , 2012, Proceedings of the National Academy of Sciences.

[78]  S. Lancel,et al.  Carbon Monoxide Improves Cardiac Function and Mitochondrial Population Quality in a Mouse Model of Metabolic Syndrome , 2012, PloS one.

[79]  S. yet,et al.  Myeloid Heme Oxygenase-1 Haploinsufficiency Reduces High Fat Diet-Induced Insulin Resistance by Affecting Adipose Macrophage Infiltration in Mice , 2012, PloS one.

[80]  D. Stevenson,et al.  Metalloporphyrins – An Update , 2012, Front. Pharmacol..

[81]  Stefan W. Ryter,et al.  Bile Pigments in Pulmonary and Vascular Disease , 2012, Front. Pharmacol..

[82]  C. Hobohm,et al.  Interrelations between blood-brain barrier permeability and matrix metalloproteinases are differently affected by tissue plasminogen activator and hyperoxia in a rat model of embolic stroke , 2012, Medical gas research.

[83]  E. Denamur,et al.  Differential antibacterial activity against Pseudomonas aeruginosa by carbon monoxide-releasing molecules. , 2012, Antioxidants & redox signaling.

[84]  M. Cieśla,et al.  Heme oxygenase-1 inhibits myoblast differentiation by targeting myomirs. , 2012, Antioxidants & redox signaling.

[85]  D. Stec,et al.  Heme oxygenase, a novel target for the treatment of hypertension and obesity? , 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

[86]  S. Ylä-Herttuala,et al.  Heme oxygenase 1 is induced by miR-155 via reduced BACH1 translation in endothelial cells. , 2011, Free radical biology & medicine.

[87]  D. Stec,et al.  Renal Inhibition of Heme Oxygenase-1 Increases Blood Pressure in Angiotensin II-Dependent Hypertension , 2011, International journal of hypertension.

[88]  D. Stevenson,et al.  Effects of Zinc Deuteroporphyrin Bis Glycol on Newborn Mice After Heme Loading , 2011, Pediatric Research.

[89]  C. Harris,et al.  Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase , 2011, Proceedings of the National Academy of Sciences.

[90]  Fadi G Lakkis,et al.  Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death , 2011, Transplant international : official journal of the European Society for Organ Transplantation.

[91]  S. Ryter,et al.  Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation. , 2011, American journal of respiratory cell and molecular biology.

[92]  Qun Zhou,et al.  miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells* , 2011, The Journal of Biological Chemistry.

[93]  R. Abboud,et al.  Effect of heme oxygenase-1 polymorphisms on lung function and gene expression , 2011, BMC Medical Genetics.

[94]  C. Peers Ion channels as target effectors for carbon monoxide , 2011, Experimental physiology.

[95]  S. Biswal,et al.  Carbon Monoxide–Activated Nrf2 Pathway Leads to Protection Against Permanent Focal Cerebral Ischemia , 2011, Stroke.

[96]  Y. Higashimoto,et al.  Caveolin-1 is a competitive inhibitor of heme oxygenase-1 (HO-1) with heme: identification of a minimum sequence in caveolin-1 for binding to HO-1. , 2011, Biochemistry.

[97]  P. Kemp,et al.  Carbon monoxide: an emerging regulator of ion channels , 2011, The Journal of physiology.

[98]  D. Ryu,et al.  The role of carbon monoxide in metabolic disease , 2011, Annals of the New York Academy of Sciences.

[99]  S. Ryter,et al.  Carbon monoxide inhibits Fas activating antibody-induced apoptosis in endothelial cells , 2011, Medical gas research.

[100]  I. Anegon,et al.  Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer. , 2011, Immunotherapy.

[101]  G. Dördelmann,et al.  Silicium dioxide nanoparticles as carriers for photoactivatable CO-releasing molecules (PhotoCORMs). , 2011, Inorganic chemistry.

[102]  Daling Zhu,et al.  Protection against lung graft injury from brain-dead donors with carbon monoxide, biliverdin, or both. , 2011, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[103]  D. Stevenson,et al.  In vitro inhibition of heme oxygenase isoenzymes by metalloporphyrins , 2011, Journal of Perinatology.

[104]  Haitao Wen,et al.  The inflammasome NLRs in immunity, inflammation, and associated diseases. , 2011, Annual review of immunology.

[105]  W. Brück,et al.  Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. , 2011, Brain : a journal of neurology.

[106]  D. Stolz,et al.  Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts. , 2011, Cardiovascular research.

[107]  H. Wada,et al.  Beneficial Effects of Perioperative Low-Dose Inhaled Carbon Monoxide on Pulmonary Allograft Survival in MHC-Inbred CLAWN Miniature Swine , 2010, Transplantation.

[108]  S. Ryter,et al.  Evaluation of inhaled carbon monoxide as an anti-inflammatory therapy in a nonhuman primate model of lung inflammation. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[109]  S. Ryter,et al.  Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicine. , 2010, Current drug targets.

[110]  V. Thayanithy,et al.  Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217* , 2010, The Journal of Biological Chemistry.

[111]  L. Otterbein,et al.  Intraoperative Administration of Inhaled Carbon Monoxide Reduces Delayed Graft Function in Kidney Allografts in Swine , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[112]  N. Sepúlveda,et al.  A Central Role for Free Heme in the Pathogenesis of Severe Sepsis , 2010, Science Translational Medicine.

[113]  W. Bao,et al.  Association between heme oxygenase-1 gene promoter polymorphisms and type 2 diabetes mellitus: a HuGE review and meta-analysis. , 2010, American journal of epidemiology.

[114]  L. Otterbein,et al.  The therapeutic potential of carbon monoxide , 2010, Nature Reviews Drug Discovery.

[115]  D. Stevenson,et al.  Metalloporphyrins in the management of neonatal hyperbilirubinemia. , 2010, Seminars in fetal & neonatal medicine.

[116]  Y. Kirino,et al.  Expression of heme oxygenase‐1 in human leukemic cells and its regulation by transcriptional repressor Bach1 , 2010, Cancer science.

[117]  D. Stec,et al.  In vivo inhibition of renal heme oxygenase with an imidazole-dioxolane inhibitor. , 2010, Pharmacological research.

[118]  T. Billiar,et al.  Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. , 2010, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[119]  H. Bonkovsky,et al.  MicroRNA‐196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins , 2010, Hepatology.

[120]  M. Ikeda-Saito,et al.  Dioxygen activation for the self-degradation of heme: reaction mechanism and regulation of heme oxygenase. , 2010, Inorganic chemistry.

[121]  D. Stolz,et al.  Ex vivo Application of Carbon Monoxide in UW Solution Prevents Transplant‐Induced Renal Ischemia/Reperfusion Injury in Pigs , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[122]  J. K. Kundu,et al.  Nrf2-Keap1 Signaling as a Potential Target for Chemoprevention of Inflammation-Associated Carcinogenesis , 2010, Pharmaceutical Research.

[123]  C. Steer,et al.  Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease , 2010, Journal of Molecular Medicine.

[124]  Mihee M. Kim,et al.  The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 , 2010, Nature Cell Biology.

[125]  M. Ikeda-Saito,et al.  Heme oxygenase reveals its strategy for catalyzing three successive oxygenation reactions. , 2010, Accounts of chemical research.

[126]  G. Schuler,et al.  Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity , 2010, Journal of leukocyte biology.

[127]  G. Vercellotti,et al.  Heme degradation and vascular injury. , 2010, Antioxidants & redox signaling.

[128]  M. Soares,et al.  Mechanisms of cell protection by heme oxygenase-1. , 2010, Annual review of pharmacology and toxicology.

[129]  Andres I Rodriguez,et al.  HO-1 and CO Decrease Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cell Migration Via Inhibition of Nox1 , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[130]  D. Stolz,et al.  Liver graft exposure to carbon monoxide during cold storage protects sinusoidal endothelial cells and ameliorates reperfusion injury in rats , 2009, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[131]  M. G. O’Sullivan,et al.  Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. , 2009, American journal of physiology. Heart and circulatory physiology.

[132]  H. Schipper,et al.  Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD. , 2009, Current Alzheimer research.

[133]  L. Otterbein,et al.  Carbon monoxide is a poison... to microbes! CO as a bactericidal molecule. , 2009, Current opinion in pharmacology.

[134]  C. Owen,et al.  High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. , 2009, American journal of respiratory cell and molecular biology.

[135]  S. Ryter,et al.  Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. , 2009, American journal of respiratory cell and molecular biology.

[136]  S. Ryter,et al.  Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. , 2009, Free radical biology & medicine.

[137]  Jae Heun Lee,et al.  Heme-Oxygenase-1 Induction and Carbon Monoxide-Releasing Molecule Inhibit Lipopolysaccharide (LPS)-Induced High-Mobility Group Box 1 Release in Vitro and Improve Survival of Mice in LPS- and Cecal Ligation and Puncture-Induced Sepsis Model in Vivo , 2009, Molecular Pharmacology.

[138]  R. Potter,et al.  CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase. , 2009, American journal of physiology. Heart and circulatory physiology.

[139]  F. Chen,et al.  Heme Oxygenase-1 microsatellite polymorphism and haplotypes are associated with the development of acute respiratory distress syndrome , 2009, Intensive Care Medicine.

[140]  Y. Hérault,et al.  Heme Oxygenase-1 Accelerates Cutaneous Wound Healing in Mice , 2009, PloS one.

[141]  G. Kollias,et al.  Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production , 2009, The Journal of experimental medicine.

[142]  R. Favory,et al.  Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis , 2009, Journal of Pharmacology and Experimental Therapeutics.

[143]  H. Vali,et al.  HO‐1‐mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues , 2009, Journal of neurochemistry.

[144]  S. Ryter,et al.  Carbon monoxide prevents ventilator-induced lung injury via caveolin-1* , 2009, Critical care medicine.

[145]  A. Nakao,et al.  Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function. , 2009, American journal of physiology. Renal physiology.

[146]  E. Denamur,et al.  A carbon monoxide‐releasing molecule (CORM‐3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[147]  S. Ryter,et al.  The Heme Oxygenase-1/Carbon Monoxide Pathway Suppresses TLR4 Signaling by Regulating the Interaction of TLR4 with Caveolin-11 , 2009, The Journal of Immunology.

[148]  S. Remy,et al.  Carbon Monoxide Inhibits TLR-Induced Dendritic Cell Immunogenicity1 , 2009, The Journal of Immunology.

[149]  Guido Sanguinetti,et al.  Carbon Monoxide-releasing Antibacterial Molecules Target Respiration and Global Transcriptional Regulators* , 2009, Journal of Biological Chemistry.

[150]  M. Carraway,et al.  Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1 , 2008, Circulation research.

[151]  C. T. Migita,et al.  Variation of the oxidation state of verdoheme in the heme oxygenase reaction. , 2008, Biochemical and biophysical research communications.

[152]  A. Choi,et al.  Ex vivo carbon monoxide prevents cytochrome P450 degradation and ischemia/reperfusion injury of kidney grafts. , 2008, Kidney international.

[153]  R. Kinobe,et al.  Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic? , 2008, Canadian journal of physiology and pharmacology.

[154]  Ping Zhang,et al.  Preconditioning of Carbon Monoxide Releasing Molecule-derived CO Attenuates LPS-induced Activation of HUVEC , 2008, International journal of biological sciences.

[155]  D. Stolz,et al.  Carbon Monoxide Ameliorates Renal Cold Ischemia-Reperfusion Injury With an Upregulation of Vascular Endothelial Growth Factor by Activation of Hypoxia-Inducible Factor , 2008, Transplantation.

[156]  S. Ryter,et al.  Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1. , 2008, American journal of respiratory and critical care medicine.

[157]  R. Foresti,et al.  Use of carbon monoxide as a therapeutic agent: promises and challenges , 2008, Intensive Care Medicine.

[158]  S. Chung,et al.  Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. , 2008, The Journal of clinical investigation.

[159]  W. Zhong,et al.  Heme oxygenase-1 attenuates ovalbumin-induced airway inflammation by up-regulation of foxp3 T-regulatory cells, interleukin-10, and membrane-bound transforming growth factor- 1. , 2007, The American journal of pathology.

[160]  D. Postma,et al.  Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study , 2007, European Respiratory Journal.

[161]  Javier Martín,et al.  HO-1 promoter polymorphism associated with rheumatoid arthritis. , 2007, Arthritis and rheumatism.

[162]  R. Motterlini,et al.  Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase Inhibitors in Renal Proximal Tubule Epithelial Cells , 2007, Journal of Pharmacology and Experimental Therapeutics.

[163]  C. Green,et al.  Improved myocardial function after cold storage with preservation solution supplemented with a carbon monoxide-releasing molecule (CORM-3). , 2007, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[164]  Wenda Gao,et al.  Heme oxygenase‐1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[165]  Y. Surh,et al.  Carbon Monoxide Produced by Heme Oxygenase-1 in Response to Nitrosative Stress Induces Expression of Glutamate-Cysteine Ligase in PC12 Cells via Activation of Phosphatidylinositol 3-Kinase and Nrf2 Signaling* , 2007, Journal of Biological Chemistry.

[166]  A. Nussler,et al.  Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. , 2007, Journal of hepatology.

[167]  R. Figueiredo,et al.  Characterization of Heme as Activator of Toll-like Receptor 4* , 2007, Journal of Biological Chemistry.

[168]  X. Chen,et al.  Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice. , 2007, The Journal of surgical research.

[169]  T. Billiar,et al.  Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[170]  A. Courtney,et al.  Association of Functional Heme Oxygenase‐1 Gene Promoter Polymorphism with Renal Transplantation Outcomes , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[171]  S. Ryter,et al.  Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death. , 2007, American journal of respiratory cell and molecular biology.

[172]  N. Abraham,et al.  Heme oxygenase -1 gene therapy: recent advances and therapeutic applications. , 2007, Current gene therapy.

[173]  H. Sakamoto,et al.  X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase. , 2007, Biochemistry.

[174]  J. Cook,et al.  How many transcription factors does it take to turn on the heme oxygenase-1 gene? , 2007, American journal of respiratory cell and molecular biology.

[175]  S. Ryter,et al.  Carbon Monoxide Protects against Hyperoxia-induced Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Formation* , 2007, Journal of Biological Chemistry.

[176]  W. Zhong,et al.  Heme Oxygenase-1-Mediated CD4+CD25high Regulatory T Cells Suppress Allergic Airway Inflammation1 , 2006, The Journal of Immunology.

[177]  Hideaki Sato,et al.  The Reactions of Heme- and Verdoheme-Heme Oxygenase-1 Complexes with FMN-depleted NADPH-cytochrome P450 Reductase , 2006, Journal of Biological Chemistry.

[178]  S. Ryter,et al.  Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts , 2006, The Journal of experimental medicine.

[179]  D. Stolz,et al.  Ex Vivo Application of Carbon Monoxide in University of Wisconsin Solution to Prevent Intestinal Cold Ischemia/Reperfusion Injury , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[180]  S. Ryter,et al.  Erratum: Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: Involvement of p38β MAPK and heat shock factor-1 (Journal of Immunology (2005) 175 (2622-2629)) , 2006 .

[181]  R. Kinobe,et al.  Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. , 2006, Journal of medicinal chemistry.

[182]  R. Gold,et al.  Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration , 2006, Clinical and experimental immunology.

[183]  W. Durante,et al.  Role of carbon monxide in cardiovascular function , 2006, Journal of cellular and molecular medicine.

[184]  J. Poderoso,et al.  HO‐1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[185]  O. Wagner,et al.  Carbon monoxide orchestrates a protective response through PPARgamma. , 2006, Immunity.

[186]  Jawed Alam,et al.  Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. , 2006, Physiological reviews.

[187]  Shivraj Tyagi,et al.  Heme oxygenase‐1 is essential for and promotes tolerance to transplanted organs , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[188]  Hui Liao,et al.  Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[189]  L. Howells,et al.  Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols , 2006, Molecular Pharmacology.

[190]  L. Otterbein,et al.  Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice. , 2006, The Journal of clinical investigation.

[191]  H. Paudel,et al.  Over‐expression of heme oxygenase‐1 promotes oxidative mitochondrial damage in rat astroglia , 2006, Journal of cellular physiology.

[192]  E. Yıldırım,et al.  Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women. , 2006, Atherosclerosis.

[193]  R. Kinobe,et al.  Selectivity of imidazole–dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms , 2006, British journal of pharmacology.

[194]  M. Gnecchi,et al.  Heme oxygenase‐1 (HO‐1) inhibits postmyocardial infarct remodeling and restores ventricular function , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[195]  Timothy R Billiar,et al.  Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. , 2006, Surgery.

[196]  A. Choi,et al.  Heart Allograft Protection with Low-Dose Carbon Monoxide Inhalation: Effects on Inflammatory Mediators and Alloreactive T-cell Responses , 2006, Transplantation.

[197]  S. Ryter,et al.  CO as a cellular signaling molecule. , 2006, Annual review of pharmacology and toxicology.

[198]  F. Liu,et al.  Biliverdin administration protects against endotoxin-induced acute lung injury in rats. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[199]  F. Bach,et al.  Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[200]  R. Foresti,et al.  Therapeutic applications of carbon monoxide-releasing molecules , 2005, Expert opinion on investigational drugs.

[201]  O. Wagner,et al.  Microsatellite polymorphism in the heme oxygenase-1 gene promoter and cardiac allograft vasculopathy. , 2005, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[202]  S. Remy,et al.  Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression. , 2005, Blood.

[203]  A. Froio,et al.  Bilirubin: A Natural Inhibitor of Vascular Smooth Muscle Cell Proliferation , 2005, Circulation.

[204]  S. Ryter,et al.  Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of p38β MAPK and Heat Shock Factor-1 1 , 2005, The Journal of Immunology.

[205]  S. Ryter,et al.  Caveolin-1 expression by means of p38β mitogen-activated protein kinase mediates the antiproliferative effect of carbon monoxide , 2005 .

[206]  A. Tsung,et al.  Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation. , 2005, Surgery.

[207]  Chien Ho,et al.  Biliverdin Administration Prevents the Formation of Intimal Hyperplasia Induced by Vascular Injury , 2005, Circulation.

[208]  R. Motterlini,et al.  Mitochondrial Respiratory Chain and NAD(P)H Oxidase Are Targets for the Antiproliferative Effect of Carbon Monoxide in Human Airway Smooth Muscle* , 2005, Journal of Biological Chemistry.

[209]  R. Foresti,et al.  Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages , 2005, British journal of pharmacology.

[210]  Y. Surh,et al.  Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells. , 2005, Biochemical and biophysical research communications.

[211]  M. Atkinson,et al.  An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells 1 , 2005, The Journal of Immunology.

[212]  Wenda Gao,et al.  Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. , 2005, Diabetes.

[213]  B. Croker,et al.  Protective effects of exogenous bilirubin on ischemia-reperfusion injury in the isolated, perfused rat kidney. , 2005, American journal of physiology. Renal physiology.

[214]  Xin-Yuan Fu,et al.  Carbon Monoxide Differentially Modulates STAT1 and STAT3 and Inhibits Apoptosis via a Phosphatidylinositol 3-Kinase/Akt and p38 Kinase-dependent STAT3 Pathway during Anoxia-Reoxygenation Injury* , 2005, Journal of Biological Chemistry.

[215]  R. Kinobe,et al.  Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors. , 2005, Bioorganic & medicinal chemistry letters.

[216]  Young-Myeong Kim,et al.  Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression. , 2005, Biochemical and biophysical research communications.

[217]  O. Wagner,et al.  Effects of carbon monoxide inhalation during experimental endotoxemia in humans. , 2005, American journal of respiratory and critical care medicine.

[218]  R. Alberto,et al.  CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[219]  D. Stolz,et al.  Protection Against Ischemia/Reperfusion Injury in Cardiac and Renal Transplantation with Carbon Monoxide, Biliverdin and Both , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[220]  H. Sakamoto,et al.  Involvement of NADP(H) in the Interaction between Heme Oxygenase-1 and Cytochrome P450 Reductase* , 2005, Journal of Biological Chemistry.

[221]  F. Bach,et al.  Biliverdin therapy protects rat livers from ischemia and reperfusion injury , 2004, Hepatology.

[222]  D. Stolz,et al.  Protection of transplant-induced renal ischemia-reperfusion injury with carbon monoxide. , 2004, American journal of physiology. Renal physiology.

[223]  O. Wagner,et al.  The role of heme oxygenase-1 promoter polymorphisms in human disease. , 2004, Free radical biology & medicine.

[224]  R. Tyrrell,et al.  Regulation of heme oxygenase-1 gene transcription: recent advances and highlights from the International Conference (Uppsala, 2003) on Heme Oxygenase. , 2004, Antioxidants & redox signaling.

[225]  R. Stocker Antioxidant activities of bile pigments. , 2004, Antioxidants & redox signaling.

[226]  Mingyao Liu,et al.  Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. , 2004, American journal of respiratory and critical care medicine.

[227]  S. Ryter,et al.  The FASEB Journal • Research Communication Caveolae compartmentalization of heme oxygenase-1 in endothelial cells , 2022 .

[228]  R. Foresti,et al.  Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule , 2004, British journal of pharmacology.

[229]  T. Cheng,et al.  Mechanism of Heme Oxygenase-1 Gene Induction by Quercetin in Rat Aortic Smooth Muscle Cells , 2004, Pharmacology.

[230]  O. Wagner,et al.  Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[231]  F. Bach,et al.  Heme oxygenase‐1‐derived carbon monoxide protects hearts from transplant‐associated ischemia reperfusion injury , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[232]  F. Bach,et al.  Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[233]  O. Wagner,et al.  Heme oxygenase-1 genotype and restenosis after balloon angioplasty: a novel vascular protective factor. , 2004, Journal of the American College of Cardiology.

[234]  A. Agarwal,et al.  The story so far: Molecular regulation of the heme oxygenase-1 gene in renal injury. , 2004, American journal of physiology. Renal physiology.

[235]  S. Ryter,et al.  Carbon monoxide in biology and medicine , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.

[236]  O. Wagner,et al.  Donor heme oxygenase-1 genotype is associated with renal allograft function1 , 2004, Transplantation.

[237]  M. Brand,et al.  Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[238]  A. Choi,et al.  MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. , 2003, The American journal of pathology.

[239]  A. Choi,et al.  Suppression of Inflammatory Cytokine Production by Carbon Monoxide Involves the JNK Pathway and AP-1* , 2003, Journal of Biological Chemistry.

[240]  D. Stolz,et al.  Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts. , 2003, Surgery.

[241]  A. Tward,et al.  Systemic Rather Than Local Heme Oxygenase-1 Overexpression Improves Cardiac Allograft Outcomes in a New Transgenic Mouse1 , 2003, The Journal of Immunology.

[242]  Simon C Watkins,et al.  Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. , 2003, The American journal of pathology.

[243]  R. Flavell,et al.  Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury* , 2003, Journal of Biological Chemistry.

[244]  A. Zampetaki,et al.  Effect of Heme Oxygenase-1 Overexpression in Two Models of Lung Inflammation , 2003, Experimental biology and medicine.

[245]  Jawed Alam,et al.  Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. , 2003, The Biochemical journal.

[246]  K. Itoh,et al.  Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[247]  G. Kikuchi,et al.  Heme oxygenase and heme degradation. , 2003, Biochemical and biophysical research communications.

[248]  N. Bodyak,et al.  Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury , 2003, Nature Medicine.

[249]  A. Choi,et al.  Carbon Monoxide Inhibition of Apoptosis during Ischemia-Reperfusion Lung Injury Is Dependent on the p38 Mitogen-activated Protein Kinase Pathway and Involves Caspase 3* , 2003, The Journal of Biological Chemistry.

[250]  D. Barañano,et al.  Biliverdin reductase: A major physiologic cytoprotectant , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[251]  A. Choi,et al.  Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[252]  Hiroshi Suzuki,et al.  Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene , 2002, The EMBO journal.

[253]  R. Cole,et al.  Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[254]  C. Liang,et al.  Cardioselective overexpression of HO-1 prevents I/R-induced cardiac dysfunction and apoptosis. , 2002, American journal of physiology. Heart and circulatory physiology.

[255]  J. Eaton,et al.  Pro-oxidant and cytotoxic effects of circulating heme. , 2002, Blood.

[256]  Takafumi Suzuki,et al.  Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system , 2002, Genes to cells : devoted to molecular & cellular mechanisms.

[257]  F. Bach,et al.  Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis* , 2002, The Journal of Biological Chemistry.

[258]  H. Volk,et al.  Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway , 2002, Hepatology.

[259]  V. Calabrese,et al.  Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. , 2002, Molecular pharmacology.

[260]  Tzong-Shyuan Lee,et al.  Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice , 2002, Nature Medicine.

[261]  Hidetada Sasaki,et al.  Bilirubin ameliorates bleomycin-induced pulmonary fibrosis in rats. , 2002, American journal of respiratory and critical care medicine.

[262]  O. Wagner,et al.  Heme Oxygenase-1 Gene Promoter Microsatellite Polymorphism is Associated with Restenosis after Percutaneous Transluminal Angioplasty , 2001, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.

[263]  Y. Nagashima,et al.  Adenovirus-mediated transfer of heme oxygenase-1 cDNA attenuates severe lung injury induced by the influenza virus in mice , 2001, Gene Therapy.

[264]  N. Abraham,et al.  Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats , 2001, Hypertension.

[265]  J. Ingwall,et al.  Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice , 2001, Circulation research.

[266]  T. Minamino,et al.  Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[267]  James L. Park,et al.  Heme oxygenase-1 protects against vascular constriction and proliferation , 2001, Nature Medicine.

[268]  Y. Nagashima,et al.  Transfer of heme oxygenase 1 cDNA by a replication-deficient adenovirus enhances interleukin 10 production from alveolar macrophages that attenuates lipopolysaccharide-induced acute lung injury in mice. , 2001, Human gene therapy.

[269]  D. Pinsky,et al.  Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis , 2001, Nature Medicine.

[270]  A. Choi,et al.  Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants1 , 2001, The Journal of Immunology.

[271]  D. Stevenson,et al.  Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis. , 2001, Blood.

[272]  C. T. Migita,et al.  Mechanism of heme degradation by heme oxygenase. , 2000, Journal of inorganic biochemistry.

[273]  A. Choi,et al.  Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis , 2000, The Journal of experimental medicine.

[274]  S. Ryter,et al.  Heme oxygenase activity causes transient hypersensitivity to oxidative ultraviolet A radiation that depends on release of iron from heme. , 2000, Free radical biology & medicine.

[275]  R. Foresti,et al.  Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. , 2000, Free radical biology & medicine.

[276]  A. Choi,et al.  Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway , 2000, Nature Medicine.

[277]  P. Sarathchandra,et al.  Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction. , 2000, American journal of physiology. Heart and circulatory physiology.

[278]  S. Ryter,et al.  The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties. , 2000, Free radical biology & medicine.

[279]  P. Dennery,et al.  Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[280]  A. Choi,et al.  Nrf2, a Cap’n’Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene* , 1999, The Journal of Biological Chemistry.

[281]  L. Kobzik,et al.  Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. , 1999, The Journal of clinical investigation.

[282]  A. Choi,et al.  Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury. , 1999, The Journal of clinical investigation.

[283]  A. Choi,et al.  Carbon monoxide provides protection against hyperoxic lung injury. , 1999, The American journal of physiology.

[284]  S. Snyder,et al.  Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[285]  S. Kourembanas,et al.  Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells* , 1997, The Journal of Biological Chemistry.

[286]  A. Choi,et al.  Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide. , 1997, American journal of physiology. Lung cellular and molecular physiology.

[287]  S. Tonegawa,et al.  Reduced stress defense in heme oxygenase 1-deficient cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[288]  S. Tonegawa,et al.  Heme oxygenase 1 is required for mammalian iron reutilization. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[289]  L. Ny,et al.  Pitfalls using metalloporphyrins in carbon monoxide research. , 1997, Trends in pharmacological sciences.

[290]  M. Maines,et al.  Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis* , 1997, The Journal of Biological Chemistry.

[291]  G. Semenza,et al.  Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia* , 1997, The Journal of Biological Chemistry.

[292]  A. Choi,et al.  Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury. , 1996, American journal of respiratory cell and molecular biology.

[293]  D. Rousseau,et al.  Oxygen and One Reducing Equivalent Are Both Required for the Conversion of -Hydroxyhemin to Verdoheme in Heme Oxygenase , 1996, The Journal of Biological Chemistry.

[294]  M. Suematsu,et al.  Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. , 1995, The Journal of clinical investigation.

[295]  S. Ebrahim,et al.  Serum bilirubin and risk of ischemic heart disease in middle-aged British men. , 1995, Clinical chemistry.

[296]  N. Abraham,et al.  Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues. , 1995, Investigative ophthalmology & visual science.

[297]  D. Stevenson,et al.  Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. , 1995, Free radical biology & medicine.

[298]  A. Choi,et al.  Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer (*) , 1995, The Journal of Biological Chemistry.

[299]  S. Kourembanas,et al.  Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[300]  M. Suematsu,et al.  Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. , 1994, Biochemical and biophysical research communications.

[301]  S. Shibahara,et al.  Identification of a cis-acting element that is responsible for cadmium-mediated induction of the human heme oxygenase gene. , 1994, The Journal of biological chemistry.

[302]  R. Stocker,et al.  Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation. , 1994, The Journal of biological chemistry.

[303]  M. Marletta,et al.  Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. , 1994, Biochemistry.

[304]  R. Tyrrell,et al.  Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[305]  J. Alam,et al.  Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals. , 1994, The Journal of biological chemistry.

[306]  R. Tyrrell,et al.  Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. , 1993, The Journal of biological chemistry.

[307]  D. Stevenson,et al.  Selection of Metalloporphyrin Heme Oxygenase Inhibitors Based on Potency and Photoreactivity , 1993, Pediatric Research.

[308]  S. Snyder,et al.  Carbon monoxide: a putative neural messenger. , 1993, Science.

[309]  J. Alam,et al.  Distal AP-1 binding sites mediate basal level enhancement and TPA induction of the mouse heme oxygenase-1 gene. , 1992, The Journal of biological chemistry.

[310]  M. Rotenberg,et al.  Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site? , 1991, Archives of biochemistry and biophysics.

[311]  T. Yoshida,et al.  Expression of rat heme oxygenase in Escherichia coli as a catalytically active, full-length form that binds to bacterial membranes. , 1991, European journal of biochemistry.

[312]  T. W. Wu,et al.  Albumin-bound bilirubins protect human ventricular myocytes against oxyradical damage. , 1991, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[313]  M. Freeman,et al.  Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells. , 1991, Archives of biochemistry and biophysics.

[314]  M. Rotenberg,et al.  Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2. , 1990, The Journal of biological chemistry.

[315]  J. Alam,et al.  Transcriptional activation of the heme oxygenase gene by heme and cadmium in mouse hepatoma cells. , 1989, The Journal of biological chemistry.

[316]  M. Maines Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications , 1988, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[317]  M. Maines,et al.  Evidence suggesting that the two forms of heme oxygenase are products of different genes. , 1988, The Journal of biological chemistry.

[318]  R. Tyrrell,et al.  Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. , 1987, The Journal of biological chemistry.

[319]  S. Shibahara,et al.  Transcriptional control of rat heme oxygenase by heat shock. , 1987, The Journal of biological chemistry.

[320]  B. Ames,et al.  Bilirubin is an antioxidant of possible physiological importance. , 1987, Science.

[321]  M. Maines,et al.  Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. , 1986, The Journal of biological chemistry.

[322]  M. Maines,et al.  Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. , 1986, The Journal of biological chemistry.

[323]  G. Kikuchi,et al.  The step of carbon monoxide liberation in the sequence of heme degradation catalyzed by the reconstituted microsomal heme oxygenase system. , 1982, The Journal of biological chemistry.

[324]  G. Kikuchi,et al.  Identification of the product of heme degradation catalyzed by the heme oxygenase system as biliverdin IX alpha by reversed-phase high-performance liquid chromatography. , 1982, Journal of biochemistry.

[325]  G. Kikuchi,et al.  Degradation of mesoheme and hydroxymesoheme catalyzed by the heme oxygenase system: involvement of hydroxyheme in the sequence of heme catabolism. , 1981, Journal of biochemistry.

[326]  G. Kikuchi,et al.  Oxygenated form of heme . heme oxygenase complex and requirement for second electron to initiate heme degradation from the oxygenated complex. , 1980, The Journal of biological chemistry.

[327]  G. Kikuchi,et al.  Specific requirement of NADPH‐cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IXα , 1979, FEBS letters.

[328]  B. Masters,et al.  Immunochemical evidence for an association of heme oxygenase with the microsomal electron transport system. , 1972, The Journal of biological chemistry.

[329]  H. Marver,et al.  Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization. , 1970, Biochemistry.

[330]  H. Marver,et al.  Microsomal heme oxygenase. Characterization of the enzyme. , 1969, The Journal of biological chemistry.

[331]  H. Marver,et al.  The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[332]  R. Blasczyk,et al.  Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells. , 2015, Free radical biology & medicine.

[333]  S. Heinemann,et al.  Dicarbonyl-bis(cysteamine)iron(II): a light induced carbon monoxide releasing molecule based on iron (CORM-S1). , 2011, Journal of inorganic biochemistry.

[334]  R. Potter,et al.  Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice. , 2008, American journal of physiology. Gastrointestinal and liver physiology.

[335]  F. Bach,et al.  Hypoxia-inducible factor 1 stabilization by carbon monoxide results in cytoprotective preconditioning , 2007 .

[336]  Ming-Wei Lin,et al.  Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. , 2004, European heart journal.

[337]  F. Bach,et al.  Carbon Monoxide Protects Pancreatic -Cells From Apoptosis and Improves Islet Function/Survival After , 2002 .

[338]  S. Shibahara,et al.  Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. , 2000, American journal of human genetics.

[339]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.

[340]  Y. Niida,et al.  Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. , 1999, The Journal of clinical investigation.

[341]  R. Wang,et al.  Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor. , 1998, Canadian journal of physiology and pharmacology.

[342]  A. Choi,et al.  Transcriptional activation of the HO-1 gene by lipopolysaccharide is mediated by 5' distal enhancers: role of reactive oxygen intermediates and AP-1. , 1998, American journal of respiratory cell and molecular biology.

[343]  M. Maines,et al.  The heme oxygenase system: a regulator of second messenger gases. , 1997, Annual review of pharmacology and toxicology.

[344]  D. Willis,et al.  Heme oxygenase: A novel target for the modulation of inflammatory response , 1996, Nature Medicine.

[345]  H. Schwertner,et al.  Association of low serum concentration of bilirubin with increased risk of coronary artery disease. , 1994, Clinical chemistry.

[346]  R. Furchgott,et al.  Endothelium-dependent and -independent vasodilation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. , 1991, Blood vessels.

[347]  R. Tyrrell,et al.  Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. , 1989, Proceedings of the National Academy of Sciences of the United States of America.