Nucleic acids, purines, pyrimidines (nucleotide synthesis).

period and has been inc luded. The factors involved in nucleotide and nu­ cleic acid synthesis in vivo have also been discussed. With certain excep­ tions, extensive discussion has been omitted of topics related to the partici­ tion of nucleotides in other metabolic processes to be revie wed in this vol­ ume, such as protein synthesis and carbohydrate metabolism. Also excluded is the extensive literature on the chemical synthesis of compounds, some of which are potential inhibitors of nucleic acid metabolism.