The Association Between Human Leucocyte Antigens (HLA) and Mortality in Community Residents Aged 85 and Older

OBJECTIVE: The association between Human Leucocyte Antigens (HLA) and aging was investigated. It is possible that HLA antigens are associated with longevity, either indirectly through disease associations or directly through involvement in the aging mechanism.

[1]  I. Rea,et al.  Is the Phenotypic Combination A1B8Cw7DR3 a Marker for Male Longevity? , 1994, Journal of the American Geriatrics Society.

[2]  M. Plummer,et al.  International agency for research on cancer. , 2020, Archives of pathology.

[3]  C. Fathman HLA and disease associations. , 1978, Mayo Clinic proceedings.

[4]  J. Ploem,et al.  Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants , 1976, Nature.

[5]  P. Giacomoni Aging and Cellular Defense Mechanisms , 1992, Annals of the New York Academy of Sciences.

[6]  P. McNamara,et al.  Lack of association between HLA and age in an aging population. , 2008, Tissue antigens.

[7]  R. Walford HENDERSON AWARD LECTURE: Studies in Immunogerontology * , 1982 .

[8]  A. Svejgaard,et al.  An HLA map of Europe. , 1978, Human heredity.

[9]  R. Walford,et al.  Influence of the main histocompatibility complex on ageing in mice , 1977, Nature.

[10]  M. Busson,et al.  HLA and longevity. , 1982, Tissue antigens.

[11]  M. Torres,et al.  Nomenclature for factors of the HLA system. , 2011, Bulletin of the World Health Organization.

[12]  J. Vandenbroucke,et al.  Parental survival, an independent predictor of longevity in middle-aged persons. , 1984, American journal of epidemiology.

[13]  Yuliya M. Zaretskaya,et al.  Major Histocompatibility Complex. , 1999, Russian journal of immunology : RJI : official journal of Russian Society of Immunology.

[14]  P. Andersen,et al.  Genetic and environmental influences on premature death in adult adoptees. , 1988, The New England journal of medicine.

[15]  W. Pierpaoli,et al.  Physiological Senescence and its Postponement: Theoretical Approaches and Rational Interventions. Second Stromboli Conference on Aging and Cancer. Stromboli, Sicily, May 28-June 1, 1990. Proceedings. , 1991, Annals of the New York Academy of Sciences.

[16]  Arne Svejgaard,et al.  Nomenclature for Factors of the HLA System, 1994 , 1994, Human immunology.

[17]  E. Remarque,et al.  IS THE PHENOTYPIC COMBINATION AlB8Cw7DR3 A MARKER FOR MALE LONGEVITY? , 1995, Journal of the American Geriatrics Society.

[18]  T. Ishii,et al.  INFLUENCE OF MAJOR HISTOCOMPATIBILITY COMPLEX REGION GENES ON HUMAN LONGEVITY AMONG OKINAWAN-JAPANESE CENTENARIANS AND NONAGENARIANS , 1987, The Lancet.