Air pollution during pregnancy and lung function in newborns: a birth cohort study

Post-natal exposure to air pollution is associated with diminished lung growth during school age. The current authors aimed to determine whether pre-natal exposure to air pollution is associated with lung function changes in the newborn. In a prospective birth cohort of 241 healthy term-born neonates, tidal breathing, lung volume, ventilation inhomogeneity and exhaled nitric oxide (eNO) were measured during unsedated sleep at age 5 weeks. Maternal exposure to particles with a 50% cut-off aerodynamic diameter of 10 μm (PM10), nitrogen dioxide (NO2) and ozone (O3), and distance to major roads were estimated during pregnancy. The association between these exposures and lung function was assessed using linear regression. Minute ventilation was higher in infants with higher pre-natal PM10 exposure (24.9 mL·min−1 per μg·m−3 PM10). The eNO was increased in infants with higher pre-natal NO2 exposure (0.98 ppb per μg·m−3 NO2). Post-natal exposure to air pollution did not modify these findings. No association was found for pre-natal exposure to O3 and lung function parameters. The present results suggest that pre-natal exposure to air pollution might be associated with higher respiratory need and airway inflammation in newborns. Such alterations during early lung development may be important regarding long-term respiratory morbidity.

[1]  H-P Hutter,et al.  Low levels of air pollution induce changes of lung function in a panel of schoolchildren , 2006, European Respiratory Journal.

[2]  Y. Janssen-Heininger,et al.  Molecular mechanisms of nitrogen dioxide induced epithelial injury in the lung , 2002, Molecular and Cellular Biochemistry.

[3]  J. Milerad,et al.  Altered breathing pattern after prenatal nicotine exposure in the young lamb. , 2002, American journal of respiratory and critical care medicine.

[4]  D. Baldwin,et al.  Optimized temperature and deadspace correction improve analysis of multiple breath washout measurements by ultrasonic flowmeter in infants , 2007, Pediatric pulmonology.

[5]  J. Stocks,et al.  INVITED REVIEW SERIES: TOBACCO AND LUNG HEALTH The effect of parental smoking on lung function and development during infancy , 2003 .

[6]  Kiros Berhane,et al.  Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study , 2007, The Lancet.

[7]  Nigel Bruce,et al.  Birth weight and exposure to kitchen wood smoke during pregnancy in rural Guatemala. , 2002, Environmental health perspectives.

[8]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[9]  S. Wilitzki,et al.  Differences in tidal breathing between infants with chronic lung diseases and healthy controls , 2005, BMC pediatrics.

[10]  J. Spengler,et al.  Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren , 2002, European Respiratory Journal.

[11]  M. Eriksen,et al.  Development of oxygen sensitivity in infants of smoking and non-smoking mothers. , 1999, Early human development.

[12]  André Nel,et al.  ATMOSPHERE: Enhanced: Air Pollution-Related Illness: Effects of Particles , 2005 .

[13]  E. von Mutius,et al.  Paediatric origins of adult lung disease , 2001, Thorax.

[14]  J. Staehelin,et al.  Spatial variability of different fractions of particulate matter within an urban environment and between urban and rural sites. , 2000, Journal of the Air & Waste Management Association.

[15]  Stefano Guerra,et al.  Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study , 2007, The Lancet.

[16]  K. Pinkerton,et al.  INFLUENCE OF AIR POLLUTION ON RESPIRATORY HEALTH DURING PERINATAL DEVELOPMENT , 2006, Clinical and experimental pharmacology & physiology.

[17]  Bert Brunekreef,et al.  Health effects of air pollution observed in cohort studies in Europe , 2007, Journal of Exposure Science and Environmental Epidemiology.

[18]  R. Slama,et al.  Traffic-Related Atmospheric Pollutants Levels during Pregnancy and Offspring’s Term Birth Weight: A Study Relying on a Land-Use Regression Exposure Model , 2007, Environmental health perspectives.

[19]  R. Kajekar.  Environmental factors and developmental outcomes in the lung. , 2007, Pharmacology & therapeutics.

[20]  S. Stick.  The contribution of airway development to paediatric and adult lung disease , 2000 .

[21]  M. Kleinman,et al.  Personal and Ambient Air Pollution is Associated with Increased Exhaled Nitric Oxide in Children with Asthma , 2006, Environmental health perspectives.

[22]  F. Holguin.  Traffic related exposures and lung function in adults , 2007, Thorax.

[23]  Christian Schindler,et al.  Living near main streets and respiratory symptoms in adults: the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults. , 2006, American journal of epidemiology.

[24]  U Ackermann-Liebrich,et al.  Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. , 1997, American journal of respiratory and critical care medicine.

[25]  E. Kerem.  Why do infants and small children breathe faster? , 1996, Pediatric pulmonology.

[26]  Tanja Pless-Mulloli,et al.  Does Particulate Air Pollution Contribute to Infant Death? A Systematic Review , 2004, Environmental health perspectives.

[27]  U. Frey,et al.  Elevated exhaled nitric oxide in newborns of atopic mothers precedes respiratory symptoms. , 2006, American journal of respiratory and critical care medicine.

[28]  N. Probst-Hensch,et al.  Reduced exposure to PM10 and attenuated age-related decline in lung function. , 2007, The New England journal of medicine.

[29]  M. Nickmilder,et al.  Relationship between ambient ozone and exhaled nitric oxide in children. , 2003, JAMA.

[30]  K. Godfrey,et al.  Relation of birth weight and childhood respiratory infection to adult lung function and death from chronic obstructive airways disease. , 1991, BMJ.

[31]  K. Berhane,et al.  The effect of air pollution on lung development from 10 to 18 years of age. , 2004, The New England journal of medicine.