Dielectric Properties of Biological Materials: Biophysical and Medical Applications

A review is given of the dielectric properties of mammalian tissues for the frequency range 1 Hz to 10 GHz. Such information is of relevance to a number of medical diagnostic and therapeutic applications which involve the use of non-ionizing electromagnetic radiation, as well as to studies of the possible biological effects arising from exposure to electric and magnetic fields. Dielectric studies of tissues and biomolecules can also aid the further understanding of some biochemical and physiological processes. The dielectric properties of amino acids, proteins, biological electrolytes, cell membranes, tissue-bound water and of normal and cancerous tissues are discussed with the emphasis being directed at the underlying molecular and biophysical processes involved. Clinical aspects such as the hyperthermic treatment of cancer and the stimulation of bone healing are discussed also.

[1]  E. A. Harrington The Dielectric Constant of Aqueous Solutions , 1916 .

[2]  H. Fricke THE ELECTRIC CAPACITY OF SUSPENSIONS WITH SPECIAL REFERENCE TO BLOOD , 1925, The Journal of general physiology.

[3]  H. Fricke,et al.  A Mathematical Treatment of the Electric Conductivity and Capacity of Disperse Systems ii. The Capacity of a Suspension of Conducting Spheroids Surrounded by a Non-Conducting Membrane for a Current of Low Frequency , 1925 .

[4]  H. Fricke,et al.  The Electric Capacity of Tumors of the Breast , 1926 .

[5]  H. Fricke,et al.  THE ELECTRIC CONDUCTIVITY AND CAPACITY OF DISPERSE SYSTEMS , 1931 .

[6]  Kenneth S. Cole,et al.  ELECTRIC PHASE ANGLE OF CELL MEMBRANES , 1932, The Journal of general physiology.

[7]  J. Wyman Dielectric Constants of Polar Solutions , 1934 .

[8]  J. Kirkwood,et al.  Theory of Solutions of Molecules Containing Widely Separated Charges with Special Application to Zwitterions , 1934 .

[9]  H. Curtis,et al.  THE ELECTRIC IMPEDANCE OF HEMOLYZED SUSPENSIONS OF MAMMALIAN ERYTHROCYTES. , 1935 .

[10]  W. J. Dunning,et al.  The dielectric constants of zwitterions and polar molecules as related to pH , 1938 .

[11]  J. Kirkwood The Dielectric Polarization of Polar Liquids , 1939 .

[12]  Thomas Rosendal Concluding Studies on the Conducting Properties of Human Skin to Alternating Current. , 1945 .

[13]  P. Debye,et al.  Electric Moments of Polar Polymers in Relation to Their Structure , 1951 .

[14]  J. B. Hasted,et al.  The dielectric estimation of protein hydration , 1952, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[15]  J. Kirkwood,et al.  The Influence of Dipole Moment Fluctuations on the Dielectric Increment of Proteins in Solution. , 1952, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Kam Li,et al.  Capacity and Conductivity of Body Tissues at Ultrahigh Frequencies , 1953, Proceedings of the IRE.

[17]  H. Schwan,et al.  Die elektrischen Eigenschaften von Muskelgewebe bei Niederfrequenz , 1954 .

[18]  E. J. Ambrose,et al.  Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells , 1956, Nature.

[19]  H. Schwan Electrical properties of tissue and cell suspensions. , 1957, Advances in biological and medical physics.

[20]  A. Wada Dielectric Properties of Polypeptide Solutions. III. Elucidation of the Critical Frequency of Dielectric Dispersion from the Molecular Shape of the α Helix , 1959 .

[21]  R. Becker The bioelectric factors in amphibian-limb regeneration. , 1961, The Journal of bone and joint surgery. American volume.

[22]  R. J. Pawluk,et al.  Effects of Electric Currents on Bone In Vivo , 1964, Nature.

[23]  H. Schwan,et al.  The Dielectric Properties of theBovine Eye Lens , 1964 .

[24]  E. Grant THE STRUCTURE OF WATER NEIGHBORING PROTEINS, PEPTIDES AND AMINO ACIDS AS DEDUCED FROM DIELECTRIC MEASUREMENTS , 1965 .

[25]  H. Schwan ELECTRICAL PROPERTIES OF BOUND WATER , 1965 .

[26]  H. Tien,et al.  Bimolecular lipid membranes: a review and a summary of some recent studies. , 1968, Chemistry and physics of lipids.

[27]  J. Coon SUMMATION OF THE SESSION ON TOXICOLOGY AND PHYSIOLOGY , 1969 .

[28]  M. Schauble,et al.  Electropotentials of normal tissue. , 1969, The Journal of surgical research.

[29]  A. Canada,et al.  The effects of dimethyl sulfoxide in lowering electrical skin resistance. , 1969, American journal of hospital pharmacy.

[30]  C. Cone Electroosmotic interactions accompanying mitosis initation in sarcoma cells in vitro. , 1969, Transactions of the New York Academy of Sciences.

[31]  C. Cone SECTION OF BIOLOGICAL AND MEDICAL SCIENCES: ELECTROOSMOTIC INTERACTIONS ACCOMPANYING MITOSIS INITIATION IN SARCOMA CELLS IN VITRO* , 1969 .

[32]  M. Schauble,et al.  Electropotentials of tumor tissue. , 1969, The Journal of surgical research.

[33]  Schauble Mk,et al.  Electropotentials of surgical specimens. , 1970 .

[34]  F. Westheimer,et al.  A reporter group at the active site of acetoacetate decarboxylase. II. Ionization constant of the amino group. , 1971, Journal of the American Chemical Society.

[35]  A. Guy,et al.  Nonionizing electromagnetic wave effects in biological materials and systems , 1972 .

[36]  E. Grant,et al.  Dielectric dispersion and dipole moment of myoglobin in water , 1972, Proceedings of the Royal Society of London. A. Mathematical and Physical Sciences.

[37]  R. Damadian,et al.  NMR in cancer. V. Electronic diagnosis of cancer by potassium (39K) nuclear magnetic resonance: spin signatures and T1 beat patterns. , 1974, Physiological chemistry and physics.

[38]  C F Hazlewood,et al.  Nuclear magnetic resonance transverse relaxation times of water protons in skeletal muscle. , 1974, Biophysical journal.

[39]  J W Moore,et al.  Membranes, ions, and impulses: Dedication to Kacy Cole , 1975 .

[40]  James C. Lin Microwave Properties of Fresh Mammalian Brain Tissues at Body Temperature , 1975, IEEE Transactions on Biomedical Engineering.

[41]  K. Foster,et al.  Effect of DMSO on the dielectric properties of canine kidney tissue. , 1976, Cryobiology.

[42]  H. L. Veen Tumor Eradication by Radiofrequency Therapy-Reply , 1976 .

[43]  H. Leveen,et al.  Tumor eradication by radiofrequency therapy. Responses in 21 patients. , 1976, JAMA.

[44]  H. Schwan,et al.  Complex permittivity of water at 25 °C , 1976 .

[45]  K. Foster,et al.  Microwave dielectric properties of tissue. Some comments on the rotational mobility of tissue water. , 1977, Biophysical journal.

[46]  Ronald Pethig,et al.  Dielectric properties of hydrated proteins at 9.9 GHz , 1977 .

[47]  E. Grant,et al.  Five-component dielectric dispersion in bovine serum albumin solution. , 1977, Physics in medicine and biology.

[48]  P. Antich,et al.  Selective Heating of Cutaneous Human Tumors at 27.12 MHz (Abstract) , 1977, 1977 IEEE MTT-S International Microwave Symposium Digest.

[49]  Andrew A. Marino,et al.  Clinical experiences with low intensity direct current stimulation of bone growth. , 1977, Clinical orthopaedics and related research.

[50]  A. Bottreau,et al.  Etude des spectres de relaxation diélectrique des solutions aqueuses de α et de β alanine , 1977 .

[51]  J. Kim,et al.  Selective Heating of Cutaneous Human Tumors at 27.12 MHz , 1978 .

[52]  R J Sheppard,et al.  Dielectric behaviour of biological molecules in solution , 1978 .

[53]  P A Bottomley,et al.  RF magnetic field penetration, phase shift and power dissipation in biological tissue: implications for NMR imaging. , 1978, Physics in medicine and biology.

[54]  Ronald Pethig,et al.  Dielectric and electronic properties of biological materials , 1979 .

[55]  J. Watson The electrical stimulation of bone healing , 1979, Proceedings of the IEEE.

[56]  K. Foster,et al.  Dielectric properties of brain tissue between 0.01 and 10 GHz. , 1979, Physics in medicine and biology.

[57]  K. Foster,et al.  The UHF and microwave dielectric properties of normal and tumour tissues: variation in dielectric properties with tissue water content. , 1980, Physics in medicine and biology.

[58]  G. Hahn,et al.  SOME HEAT TRANSFER PROBLEMS ASSOCIATED WITH HEATING BY ULTRASOUND, MICROWAVES, OR RADIO FREQUENCY * , 1980, Annals of the New York Academy of Sciences.

[59]  E. C. Burdette,et al.  Microwave thawing of frozen kidneys: a theoretically based experimentally-effective design. , 1980, Cryobiology.

[60]  E. C. Burdette,et al.  In Vivo Probe Measurement Technique for Determining Dielectric Properties at VHF through Microwave Frequencies , 1980 .

[61]  Stuchly,et al.  DIELECTRIC PROPERTIES OF BIOLOGICAL SUBSTANCES–TABULATED , 1980 .

[62]  E. Gratton,et al.  Correlation of IR spectroscopic, heat capacity, diamagnetic susceptibility and enzymatic measurements on lysozyme powder , 1980, Nature.

[63]  Wim G. J. Hol,et al.  Dipoles of the α-helix and β-sheet: their role in protein folding , 1981, Nature.

[64]  K. Foster,et al.  Dielectric properties of tumor and normal tissues at radio through microwave frequencies. , 1981, The Journal of microwave power.

[65]  S. Stuchly,et al.  Dielectric Behavior of Selected Animal Tissues in Vitro at Frequencies from 2 to 4 GHz , 1981, IEEE Transactions on Biomedical Engineering.

[66]  R. Pethig,et al.  Electrical properties of proteins as a function of hydration and NaCl content , 1981 .

[67]  R. Pethig,et al.  Water structure-dependent charge transport in proteins. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M A Stuchly,et al.  Dielectric properties of animal tissues in vivo at radio and microwave frequencies: comparison between species. , 1982, Physics in medicine and biology.

[69]  P. Matthews,et al.  The complex permittivity of human tissue at microwave frequencies. , 1982, Physics in medicine and biology.

[70]  Robert Plonsey,et al.  The Four-Electrode Resistivity Technique as Applied to Cardiac Muscle , 1982, IEEE Transactions on Biomedical Engineering.

[71]  K. Foster,et al.  Dielectric properties of mammalian tissues from 0.1 to 100 MHz: a summary of recent data. , 1982, Physics in medicine and biology.

[72]  J. Bonnell Effects of Electric Fields near Power-Transmission Plant , 1982, Journal of the Royal Society of Medicine.

[73]  F R Salemme,et al.  alpha-Helix dipole model and electrostatic stabilization of 4-alpha-helical proteins. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[74]  R. Pethig,et al.  Dielectric studies of the binding of water to lysozyme. , 1982, Journal of molecular biology.

[75]  C Gabriel,et al.  Dielectric properties of ocular tissues at 37 degrees C. , 1983, Physics in medicine and biology.

[76]  K. Foster,et al.  Dielectric Permittivity and Electrical Conductivity of Fluid Saturated Bone , 1983, IEEE Transactions on Biomedical Engineering.

[77]  E. Grant,et al.  The dielectric properties of normal and tumour mouse tissue between 50 MHz and 10 GHz. , 1983, The British journal of radiology.

[78]  A. Barker,et al.  The effects of pulsed magnetic fields of the type used in the stimulation of bone fracture healing. , 1983, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[79]  G. Glazebrook,et al.  The effect of dimethysulphoxide (DMSO) on heat distribution during radiofrequency (RF) capactive heating. , 1983, The British journal of radiology.

[80]  D W Armitage,et al.  Radiofrequency-induced hyperthermia: computer simulation of specific absorption rate distributions using realistic anatomical models. , 1983, Physics in medicine and biology.

[81]  F. Hart Some precautions in the use of time-domain dielectric spectroscopy with biological and other lossy dielectrics , 2006, Medical and Biological Engineering and Computing.

[82]  R. Sheridan,et al.  a-Helix dipole model and electrostatic stabilization of 4-a-helical proteins , 2022 .