A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth

The secreted morphogen Wingless promotes Drosophila wing growth by fueling a wave front of Fat-Dachsous signaling that recruits new cells into the wing primordium.

[1]  S. Cohen,et al.  The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila , 2006, Cell.

[2]  William M. Gelbart,et al.  Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster , 1982, Cell.

[3]  Yaopan Mao,et al.  Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila , 2006, Development.

[4]  K. Basler,et al.  Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels , 2008, Development.

[5]  Manuel Calleja,et al.  Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing , 1996, Nature.

[6]  C. M. Chen,et al.  Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila. , 1999, Development.

[7]  Janet Rossant,et al.  The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. , 2009, Developmental cell.

[8]  R. Fehon,et al.  Delineation of a Fat tumor suppressor pathway , 2006, Nature Genetics.

[9]  T. Wolff,et al.  The Cadherins Fat and Dachsous Regulate Dorsal/Ventral Signaling in the Drosophila Eye , 2002, Current Biology.

[10]  D. Flagiello,et al.  SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila , 2008, Current Biology.

[11]  P. Lawrence,et al.  Developmental Compartments and Planar Polarity in Drosophila , 2002, Current Biology.

[12]  T. Xu,et al.  Mosaic analysis using FLP recombinase. , 1994, Methods in cell biology.

[13]  N. Perrimon,et al.  wingless refines its own expression domain on the Drosophila wing margin , 1996, Nature.

[14]  G. Struhl,et al.  Direct and Long-Range Action of a Wingless Morphogen Gradient , 1996, Cell.

[15]  S. Carroll,et al.  The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. , 1998, Genes & development.

[16]  K. Irvine,et al.  The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation , 2008, Development.

[17]  F. Gage,et al.  YAP regulates neural progenitor cell number via the TEA domain transcription factor. , 2008, Genes & development.

[18]  I. Guerrero,et al.  Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. , 1994, The EMBO journal.

[19]  H. Krause,et al.  Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. , 1998, Genes & development.

[20]  N. Perrimon,et al.  Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.

[21]  Sean B. Carroll,et al.  Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene , 1996, Nature.

[22]  Konrad Basler,et al.  Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein , 1994, Nature.

[23]  Peter A. Lawrence,et al.  Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs? , 2008, Nature Cell Biology.

[24]  S. Carroll,et al.  Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary , 1994, Nature.

[25]  John B. Thomas,et al.  The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. , 1994, Development.

[26]  X. Franch-Marro,et al.  Wingless Promotes Proliferative Growth in a Gradient-Independent Manner , 2009, Science Signaling.

[27]  J. Charlton,et al.  Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling. , 1998, Development.

[28]  K. Harvey,et al.  The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network , 2007, Nature Reviews Cancer.

[29]  Dragana Rogulja,et al.  Morphogen control of wing growth through the Fat signaling pathway. , 2008, Developmental cell.

[30]  F. Díaz-Benjumea,et al.  Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. , 1995, Development.

[31]  John Tyler Bonner,et al.  Morphogenesis , 1965, Cell.

[32]  C. Neumann,et al.  Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. , 1997, Development.

[33]  G. Struhl,et al.  Protein kinase A and hedgehog signaling in drosophila limb development , 1995, Cell.

[34]  Liqun Luo,et al.  Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis , 1999, Neuron.

[35]  David Strutt,et al.  Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled. , 2002, Developmental cell.

[36]  Shian Wu,et al.  The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. , 2008, Developmental cell.

[37]  Jeffrey D. Axelrod,et al.  Fidelity in planar cell polarity signalling , 2003, Nature.

[38]  N. Tapon,et al.  The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway , 2006, Current Biology.

[39]  K. Harvey,et al.  Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway , 2006, Current Biology.

[40]  J. Villano,et al.  four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila. , 1995, Development.

[41]  A. Garcı́a-Bellido,et al.  Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. , 1996, Development.

[42]  Jeffrey D. Axelrod,et al.  Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye , 2002, Cell.

[43]  M. Simon Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression , 2004, Development.

[44]  S. Carroll,et al.  Binding of the Vestigial co-factor switches the DNA-target selectivity of the Scalloped selector protein. , 2001, Development.

[45]  S. Blair Compartments and appendage development in Drosophila , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[46]  K. Irvine,et al.  Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling , 2004, Development.

[47]  P. Lawrence,et al.  Planar cell polarity: one or two pathways? , 2007, Nature Reviews Genetics.

[48]  S. Cohen,et al.  Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila , 1993, Cell.

[49]  G. Halder,et al.  Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation , 2008, Proceedings of the National Academy of Sciences.

[50]  G. Struhl,et al.  Direct and Long-Range Action of a DPP Morphogen Gradient , 1996, Cell.

[51]  B. Wang,et al.  The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. , 2008, Developmental cell.

[52]  K. Golic Site-specific recombination between homologous chromosomes in Drosophila. , 1991, Science.

[53]  K. Irvine,et al.  Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains , 2008, Science.

[54]  Dragana Rogulja,et al.  Regulation of Cell Proliferation by a Morphogen Gradient , 2005, Cell.

[55]  S. Blair,et al.  Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing , 2004, Development.

[56]  S. Blair,et al.  Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins , 2006, Development.

[57]  Jianbin Huang,et al.  The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP , 2005, Cell.

[58]  Peter A Lawrence,et al.  Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity , 2006, Development.

[59]  T. Vogt,et al.  Dorsal-ventral signaling in limb development. , 1997, Current opinion in cell biology.

[60]  W. Gelbart,et al.  Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary , 1990, Mechanisms of Development.

[61]  G. Halder,et al.  The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway , 2006, Current Biology.

[62]  P. Lawrence,et al.  Measuring dimensions: the regulation of size and shape. , 2000, Development.

[63]  G. Struhl,et al.  Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation , 2007, Development.

[64]  R. Jaenisch,et al.  YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells , 2007, Current Biology.

[65]  B. Edgar,et al.  From Cell Structure to Transcription: Hippo Forges a New Path , 2006, Cell.

[66]  Kirby D. Johnson,et al.  Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic , 1997, Nature.

[67]  G. Struhl,et al.  Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. , 1995, Development.

[68]  C. H. Waddington,et al.  Developmental systems : insects , 1972 .

[69]  Ryan S. Udan,et al.  The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size , 2006, Current Biology.

[70]  Konrad Basler,et al.  Organizing activity of wingless protein in Drosophila , 1993, Cell.

[71]  G. Struhl,et al.  Control of Drosophila wing growth by the vestigial quadrant enhancer , 2007, Development.

[72]  David Strutt,et al.  Cleavage and secretion is not required for Four-jointed function in Drosophila patterning , 2004, Development.