Ocular Pulse Amplitude in Patients with Thyroid-associated Ophthalmopathy

Purpose TO determine ocular pulse volume values in patients with thyroid-associated ophthalmopathy with normal intraocular pressure, and to test the hypothesis that changes in orbital tissue that accompany thyroid-associated ophthalmopathy can in turn give changes in choroidal perfusion. Methods In a prospective study, we evaluated 30 eyes of 30 consecutive patients with TAO, and 30 eyes of 30 healthy subjects. Complete ophthalmologic examination including dynamic contour tonometry was done. Possible differences in ocular parameters between the tested groups were assessed. Results NO significant difference was found in ocular pulse volume values between the tested subjects (paired test p=0.23). Conclusions The orbit tissue changes that are involved in thyroid-associated ophthalmopathy do not have much implication on choroidal perfusion, at least when intraocular pressure values remain within the normal range.

[1]  M. L. V. Rodrigues,et al.  Graves' orbitopathy: frequency of ocular hypertension and glaucoma , 2009, Eye.

[2]  J. Flammer,et al.  Ocular Blood Flow and Glaucomatous Optic Neuropathy , 2009 .

[3]  E. Higginbotham,et al.  Glaucoma Associated With Increased Episcleral Venous Pressure , 2008 .

[4]  Y. Mehrabi,et al.  Prevalence of Open-angle Glaucoma, Glaucoma Suspect, and Ocular Hypertension in Thyroid-related Immune Orbitopathy , 2007, Journal of glaucoma.

[5]  Shan C. Lin,et al.  Dynamic contour tonometry: principle and use , 2006, Clinical & experimental ophthalmology.

[6]  H. Kanngiesser,et al.  Dynamic Contour Tonometry: Presentation of a New Tonometer , 2005, Journal of glaucoma.

[7]  Ming-Wei Lin,et al.  Pulsatile ocular blood flow in patients with Graves' ophthalmopathy , 2005, Eye.

[8]  I. Goldberg.  Thyroid eye disease and glaucoma. , 2003, Journal of glaucoma.

[9]  O. Schwenn,et al.  Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension , 2002, The British journal of ophthalmology.

[10]  H. Esgin,et al.  Ocular pulse amplitude in patients with Graves' disease: a preliminary study. , 1999, Acta ophthalmologica Scandinavica.

[11]  M. Mourits,et al.  Prevalence and management of elevated intraocular pressure in patients with Graves’ orbitopathy , 1998, The British journal of ophthalmology.

[12]  J S Kennerdell,et al.  The prevalence and implications of ocular hypertension and glaucoma in thyroid-associated orbitopathy. , 1997, Ophthalmology.

[13]  Fish Dr,et al.  Upgaze intraocular pressure changes and strabismus in graves' ophthalmopathy , 1991 .

[14]  S. Benes,et al.  Upgaze intraocular pressure changes and strabismus in Graves' ophthalmopathy. , 1991, Journal of Clinical Neuro-Ophthalmology.

[15]  S C Werner,et al.  Classification of the eye changes of Graves' disease. , 1969, American journal of ophthalmology.