First-in-human phase I study of the DNA-repair inhibitor DT01 in combination with radiotherapy in patients with skin metastases from melanoma

[1]  M. Dutreix,et al.  The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis , 2015, Molecular Cancer Therapeutics.

[2]  David E. Fisher,et al.  The melanoma revolution: From UV carcinogenesis to a new era in therapeutics , 2014, Science.

[3]  M. Dutreix,et al.  A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma , 2014, Neoplasia.

[4]  M. Dutreix,et al.  Colorectal cancer metastasis: the DNA repair inhibitor Dbait increases sensitivity to hyperthermia and improves efficacy of radiofrequency ablation. , 2014, Radiology.

[5]  Antoni Ribas,et al.  Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. , 2013, The New England journal of medicine.

[6]  Chris Fellner.  Ipilimumab (yervoy) prolongs survival in advanced melanoma: serious side effects and a hefty price tag may limit its use. , 2012, P & T : a peer-reviewed journal for formulary management.

[7]  M. Dutreix,et al.  Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol , 2012, Molecular therapy. Nucleic acids.

[8]  Jedd D. Wolchok,et al.  Immunologic correlates of the abscopal effect in a patient with melanoma. , 2012, The New England journal of medicine.

[9]  M. Dutreix,et al.  Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer , 2012, Journal of Gastroenterology.

[10]  R. Dummer,et al.  Phase II, Open-Label, Randomized Trial of the MEK1/2 Inhibitor Selumetinib as Monotherapy versus Temozolomide in Patients with Advanced Melanoma , 2011, Clinical Cancer Research.

[11]  M. Dutreix,et al.  Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems , 2011, Cancer Gene Therapy.

[12]  K. Savage,et al.  Long-term survival in patients with metastatic melanoma treated with DTIC or temozolomide. , 2010, The oncologist.

[13]  Axel Hoos,et al.  Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria , 2009, Clinical Cancer Research.

[14]  Paola Savoia,et al.  Skin metastases of malignant melanoma: a clinical and prognostic survey , 2009, Melanoma research.

[15]  M. Dutreix,et al.  Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response , 2009, PloS one.

[16]  A. Judge,et al.  siRNA and innate immunity. , 2009, Oligonucleotides.

[17]  Jean-Luc Coll,et al.  Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy , 2009, Clinical Cancer Research.

[18]  O. Fodstad,et al.  Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling , 2008, Pigment cell & melanoma research.

[19]  Thomas Helleday,et al.  DNA repair pathways as targets for cancer therapy , 2008, Nature Reviews Cancer.

[20]  P. Brown,et al.  A higher radiotherapy dose is associated with more durable palliation and longer survival in patients with metastatic melanoma , 2007, Cancer.

[21]  M. Middleton,et al.  DNA repair pathways in drug resistance in melanoma , 2004, Anti-cancer drugs.

[22]  J. Cooper,et al.  Fraction size in external beam radiation therapy in the treatment of melanoma. , 1991, International journal of radiation oncology, biology, physics.

[23]  B. Emami,et al.  Malignant melanoma: analysis of dose fractionation in radiation therapy. , 1987, Radiology.

[24]  D. Kingsley.  An interesting case of possible abscopal effect in malignant melanoma. , 1975, The British journal of radiology.

[25]  A. Hauschild,et al.  Improved overall survival in melanoma with combined dabrafenib and trametinib. , 2015, The New England journal of medicine.

[26]  A. Eggermont,et al.  Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration , 2013, Angiogenesis.

[27]  I. Radford.  The level of induced DNA double-strand breakage correlates with cell killing after X-irradiation. , 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.