Gender and race/ethnicity differences in lead dose biomarkers.

OBJECTIVES We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects. METHODS Participants aged 50 to 70 years (N=1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and (109)Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations. RESULTS Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) mug/dL, 18.9 (12.5) mug/g, and 6.8 (18.1) mug/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P < .01). We observed effect modification by race/ethnicity on the association of gender and physical activity to blood lead concentrations and by gender on the association of age to tibia lead concentrations. Patella lead concentrations differed by gender; apolipoprotein E genotype modified this relation. CONCLUSIONS African Americans evidenced a prominent disparity in lifetime lead dose. Women may be at higher risk of release of lead from bone and consequent health effects because of increased bone demineralization with aging.

[1]  Kathryn Ziegler-Graham,et al.  Forecasting the global burden of Alzheimer’s disease , 2007, Alzheimer's & Dementia.

[2]  B S Schwartz,et al.  Environmental lead exposure and cognitive function in community-dwelling older adults , 2006, Neurology.

[3]  B. Schwartz,et al.  Changes in Systolic Blood Pressure Associated With Lead in Blood and Bone , 2006, Epidemiology.

[4]  Yi-Jung Li,et al.  Low-level environmental exposure to lead and progressive chronic kidney diseases. , 2006, The American journal of medicine.

[5]  B. Weiss,et al.  Social Ecology of Children’s Vulnerability to Environmental Pollutants , 2006, Environmental health perspectives.

[6]  T. Glass,et al.  Association of blood lead and tibia lead with blood pressure and hypertension in a community sample of older adults. , 2006, American journal of epidemiology.

[7]  I. Rosenberg,et al.  Homocysteine and cognitive function. , 2005, Seminars in vascular medicine.

[8]  Thomas A Glass,et al.  Homocysteine and Cognitive Function in a Population‐Based Study of Older Adults , 2005, Journal of the American Geriatrics Society.

[9]  Howard Hu,et al.  Bone, blood and semen lead in men with environmental and moderate occupational exposure , 2005, International journal of environmental health research.

[10]  A. Spiro,et al.  Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. , 2004, American journal of epidemiology.

[11]  B. Schwartz,et al.  Associations among Lead Dose Biomarkers, Uric Acid, and Renal Function in Korean Lead Workers , 2004, Environmental health perspectives.

[12]  M. Thun,et al.  Prospective study of cigarette smoking and amyotrophic lateral sclerosis. , 2004, American journal of epidemiology.

[13]  Howard Hu,et al.  Determinants of Bone and Blood Lead Levels among Minorities Living in the Boston Area , 2004, Environmental health perspectives.

[14]  G. Glass,et al.  Disparities in cognitive functioning by race/ethnicity in the Baltimore Memory Study. , 2004, Environmental health perspectives.

[15]  F. Speizer,et al.  Correlates of bone and blood lead levels among middle-aged and elderly women. , 2002, American journal of epidemiology.

[16]  Howard Hu,et al.  Occupational determinants of bone and blood lead levels in middle aged and elderly men from the general community: the Normative Aging Study. , 2002, American journal of industrial medicine.

[17]  David Simon,et al.  ApoE genotype, past adult lead exposure, and neurobehavioral function. , 2002, Environmental health perspectives.

[18]  D. Rubinfeld,et al.  Econometric models and economic forecasts , 2002 .

[19]  Karen Bandeen-Roche,et al.  Building marginal models for multiple ordinal measurements , 2002 .

[20]  M. Daniels,et al.  A hierarchical modelling approach to analysing longitudinal data with drop‐out and non‐compliance, with application to an equivalence trial in paediatric acquired immune deficiency syndrome , 2002 .

[21]  M. Gilbertson,et al.  Community health profile of Windsor, Ontario, Canada: anatomy of a Great Lakes area of concern. , 2001, Environmental health perspectives.

[22]  S. Weiss,et al.  The delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bone and blood lead levels in community-exposed men: the Normative Aging Study. , 2001, Environmental health perspectives.

[23]  R. Brookmeyer,et al.  Aging and the public health effects of dementia. , 2001, The New England journal of medicine.

[24]  W. Stewart,et al.  Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes. , 2001, Environmental health perspectives.

[25]  B S Schwartz,et al.  Characterization of toxicokinetics and toxicodynamics with linear systems theory: application to lead-associated cognitive decline. , 2001, Environmental health perspectives.

[26]  Howard Hu,et al.  Lead Toxicity in Older Adults , 2000, Journal of the American Geriatrics Society.

[27]  W. Stewart,et al.  Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes. , 2000, Environmental health perspectives.

[28]  Howard Hu,et al.  Vibration perception thresholds in workers with long term exposure to lead , 2000, Occupational and environmental medicine.

[29]  H. Needleman,et al.  The removal of lead from gasoline: historical and personal reflections. , 2000, Environmental research.

[30]  Howard Hu,et al.  Determinants of bone and blood lead concentrations in the early postpartum period , 2000, Occupational and environmental medicine.

[31]  D Simon,et al.  Associations of tibial lead levels with BsmI polymorphisms in the vitamin D receptor in former organolead manufacturing workers. , 2000, Environmental health perspectives.

[32]  N. Krieger,et al.  Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men: the Normative Aging Study. , 1999, American Journal of Epidemiology.

[33]  M. García-Ramírez,et al.  Genetic Determinants of Bone Mass , 1999, Hormone Research in Paediatrics.

[34]  E W Gunter,et al.  Exposure of the U.S. population to lead, 1991-1994. , 1998, Environmental health perspectives.

[35]  R Brookmeyer,et al.  Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. , 1998, American journal of public health.

[36]  Howard Hu,et al.  Bone lead as a biological marker in epidemiologic studies of chronic toxicity: conceptual paradigms. , 1998, Environmental health perspectives.

[37]  C. Landrigan,et al.  Age and secular trends in bone lead levels in middle-aged and elderly men: three-year longitudinal follow-up in the Normative Aging Study. , 1997, American journal of epidemiology.

[38]  Y. Ouchi,et al.  Association of Bone Mineral Density with Apolipoprotein E Phenotype , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  J. Hoppin,et al.  In vivo bone lead measurement in suburban teenagers. , 1997, Pediatrics.

[40]  A. Rotnitzky,et al.  Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men. The normative aging study. , 1996, American journal of epidemiology.

[41]  I. Romieu,et al.  Dietary and environmental determinants of blood and bone lead levels in lactating postpartum women living in Mexico City. , 1996, Environmental health perspectives.

[42]  B. Lanphear,et al.  Racial differences in Urban children's environmental exposures to lead. , 1996, American journal of public health.

[43]  J. Osterloh,et al.  Use of endogenous, stable lead isotopes to determine release of lead from the skeleton. , 1996, Environmental health perspectives.

[44]  A. Rotnitzky,et al.  K X-ray fluorescence measurements of bone lead concentration: the analysis of low-level data , 1995, Physics in medicine and biology.

[45]  I. Hertz-Picciotto,et al.  Blood lead levels in relation to menopause, smoking, and pregnancy history. , 1995, American journal of epidemiology.

[46]  J. Kanis,et al.  Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Synopsis of a WHO report , 1994, Osteoporosis International.

[47]  K. Zimmermann,et al.  PRACTITIONERS CORNER: Goodness of Fit Measures in the Tobit Model† , 1994 .

[48]  M. J. Brown,et al.  Poisoned landscapes: the epidemiology of environmental lead exposure in Massachusetts children 1990-1991. , 1994, Social science & medicine.

[49]  K. Flegal,et al.  The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES) , 1994, JAMA.

[50]  K. Flegal,et al.  Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991) , 1994, JAMA.

[51]  A C Todd,et al.  In vivo X-ray fluorescence of lead in bone: review and current issues. , 1994, Environmental health perspectives.

[52]  C E Becker,et al.  Factors influencing bone lead concentration in a suburban community assessed by noninvasive K x-ray fluorescence. , 1994, JAMA.

[53]  C. Caspersen,et al.  A survey for assessing physical activity among older adults. , 1993, Medicine and science in sports and exercise.

[54]  R Attewell,et al.  In vivo measurements of lead in bone in long-term exposed lead smelter workers. , 1993, Archives of environmental health.

[55]  R. Desnick,et al.  The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. , 1991, Environmental research.

[56]  M. Rabinowitz,et al.  Toxicokinetics of bone lead. , 1991, Environmental health perspectives.

[57]  D. Chettle,et al.  Lead in bone: sampling and quantitation using K X-rays excited by 109Cd. , 1991, Environmental health perspectives.

[58]  D L Alexander,et al.  Chronic Lead Exposure , 1989, AAOHN journal : official journal of the American Association of Occupational Health Nurses.

[59]  E. Silbergeld,et al.  Lead and osteoporosis: mobilization of lead from bone in postmenopausal women. , 1988, Environmental research.

[60]  K Y Liang,et al.  Longitudinal data analysis for discrete and continuous outcomes. , 1986, Biometrics.

[61]  J. F. Rosen.  The metabolism of lead in isolated bone cell populations: interactions between lead and calcium. , 1983, Toxicology and applied pharmacology.

[62]  J L Annest,et al.  Chronological trend in blood lead levels between 1976 and 1980. , 1983, The New England journal of medicine.

[63]  D. Cheek.  Body composition studies. , 1980, The American journal of clinical nutrition.

[64]  G. Wetherill,et al.  Kinetic analysis of lead metabolism in healthy humans. , 1976, The Journal of clinical investigation.

[65]  L. Tepper,et al.  A survey of air and population lead levels in selected American communities. , 1972, Environmental quality and safety. Supplement.

[66]  M. Escobar,et al.  The use of the Tobit model for analyzing measures of health status , 2004, Quality of Life Research.

[67]  S. Tong,et al.  Environmental lead exposure: a public health problem of global dimensions. , 2000, Bulletin of the World Health Organization.

[68]  J. Cauley,et al.  Recent progress in understanding the genetic susceptibility to osteoporosis , 1999, Genetic epidemiology.

[69]  F. McNeill,et al.  In vivo measurements of lead in bone using a 109Cd 'spot' source. , 1993, Basic life sciences.

[70]  C. Fullmer.  Intestinal interactions of lead and calcium. , 1992, Neurotoxicology.

[71]  S. Skerfving,et al.  Lead in finger-bone analysed in vivo in active and retired lead workers. , 1984, American journal of industrial medicine.

[72]  Levine Ls,et al.  A survey of air and population lead levels in selected American communities. , 1975 .