Organic Multi-Channel Optoelectronic Sensors for Wearable Health Monitoring

Recent progress in printed optoelectronics and their integration in wearable sensors have created new avenues for research in reflectance photoplethysmography (PPG) and oximetry. The reflection-mode sensor, which consists of light emitters and detectors, is a vital component of reflectance oximeters. Here, we report a systematic study of the reflectance oximeter sensor design in terms of component geometry, light emitter and detector spacing, and the use of an optical barrier between the emitter and the detector to maximize sensor performance. Printed red and near-infrared (NIR) organic light-emitting diodes (OLEDs) and organic photodiodes (OPDs) are used to design three sensor geometries: (1) Rectangular geometry, where square OLEDs are placed at each side of the OPD; (2) Bracket geometry, where the OLEDs are shaped as brackets and placed around the square OPD; (3) Circular geometry, where the OLEDs are shaped as block arcs and placed around the circular OPD. Utilizing the bracket geometry, we observe 39.7% and 18.2% improvement in PPG signal magnitude in the red and NIR channels compared to the rectangular geometry, respectively. Using the circular geometry, we observe 48.6% and 9.2% improvements in the red and NIR channels compared to the rectangular geometry. Furthermore, a wearable two-channel PPG sensor is utilized to add redundancy to the measurement. Finally, inverse-variance weighting and template matching algorithms are implemented to improve the detection of heart rate from the multi-channel PPG signals.

[1]  Hyonyoung Han,et al.  Development of real-time motion artifact reduction algorithm for a wearable photoplethysmography , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[2]  Hoi-Jun Yoo,et al.  Toward all-day wearable health monitoring: An ultralow-power, reflective organic pulse oximetry sensing patch , 2018, Science Advances.

[3]  Zhilin Zhang,et al.  TROIKA: A General Framework for Heart Rate Monitoring Using Wrist-Type Photoplethysmographic Signals During Intensive Physical Exercise , 2014, IEEE Transactions on Biomedical Engineering.

[4]  R. Ghaffari,et al.  Recent Advances in Flexible and Stretchable Bio‐Electronic Devices Integrated with Nanomaterials , 2016, Advanced materials.

[5]  David A. Clifton,et al.  Signal-Quality Indices for the Electrocardiogram and Photoplethysmogram: Derivation and Applications to Wireless Monitoring , 2015, IEEE Journal of Biomedical and Health Informatics.

[6]  M. Kaltenbrunner,et al.  Ultraflexible organic photonic skin , 2016, Science Advances.

[7]  John G. Webster,et al.  Design of Pulse Oximeters , 1997 .

[8]  Rabab Ward,et al.  An optimal filter for short photoplethysmogram signals , 2018, Scientific Data.

[9]  Ji Woong Yu,et al.  Highly conductive, stretchable and biocompatible Ag–Au core–sheath nanowire composite for wearable and implantable bioelectronics , 2018, Nature Nanotechnology.

[10]  Donggeon Han,et al.  Flexible Blade‐Coated Multicolor Polymer Light‐Emitting Diodes for Optoelectronic Sensors , 2017, Advanced materials.

[11]  Zhilin Zhang.  Heart rate monitoring from wrist-type photoplethysmographic (PPG) signals during intensive physical exercise , 2014, 2014 IEEE Global Conference on Signal and Information Processing (GlobalSIP).

[12]  Liwei Lin,et al.  Local electrochemical control of hydrogel microactuators in microfluidics , 2018, Journal of Micromechanics and Microengineering.

[13]  Yuan-Hsiang Lin,et al.  A Pulse Rate Detection Method for Mouse Application Based on Multi-PPG Sensors , 2017, Sensors.

[14]  Claire M. Lochner,et al.  All-organic optoelectronic sensor for pulse oximetry , 2014, Nature Communications.

[15]  E. Hari Krishna,et al.  A Novel Approach for Motion Artifact Reduction in PPG Signals Based on AS-LMS Adaptive Filter , 2012, IEEE Transactions on Instrumentation and Measurement.

[16]  Yasser Khan,et al.  High-performance flexible energy storage and harvesting system for wearable electronics , 2016, Scientific Reports.

[17]  J. Gotman,et al.  A patient-specific algorithm for the detection of seizure onset in long-term EEG monitoring: possible use as a warning device , 1997, IEEE Transactions on Biomedical Engineering.

[18]  T. Trung,et al.  Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human‐Activity Monitoringand Personal Healthcare , 2016, Advanced materials.

[19]  Donggeon Han,et al.  Emission Area Patterning of Organic Light‐Emitting Diodes (OLEDs) via Printed Dielectrics , 2018, Advanced Functional Materials.

[20]  Jan M. Rabaey,et al.  Fabrication and Characterization of Flexible Spray-Coated Antennas , 2018, IEEE Access.

[21]  K. Ghose,et al.  Reliability Challenges in Fabrication of Flexible Hybrid Electronics for Human Performance Monitors: A System-Level Study , 2019, IEEE Transactions on Components, Packaging, and Manufacturing Technology.

[22]  Weidong Wang,et al.  Motion artifact removal from photoplethysmographic signals by combining temporally constrained independent component analysis and adaptive filter , 2014, Biomedical engineering online.

[23]  Andres A. Aguirre-Pablo,et al.  Recyclable Nonfunctionalized Paper‐Based Ultralow‐Cost Wearable Health Monitoring System , 2017 .

[24]  Ki H. Chon,et al.  Improving Pulse Rate Measurements during Random Motion Using a Wearable Multichannel Reflectance Photoplethysmograph , 2016, Sensors.

[25]  Jung Woo Lee,et al.  Battery-free, stretchable optoelectronic systems for wireless optical characterization of the skin , 2016, Science Advances.

[26]  Luca Benini,et al.  An EMG Gesture Recognition System with Flexible High-Density Sensors and Brain-Inspired High-Dimensional Classifier , 2018, 2018 IEEE International Symposium on Circuits and Systems (ISCAS).

[27]  Takao Someya,et al.  The rise of plastic bioelectronics , 2016, Nature.

[28]  Kanad Ghose,et al.  A Wearable Flexible Hybrid Electronics ECG Monitor , 2016, 2016 IEEE 66th Electronic Components and Technology Conference (ECTC).

[29]  Atif Shamim,et al.  Low cost inkjet printed smart bandage for wireless monitoring of chronic wounds , 2016, IMS 2016.

[30]  Donggeon Han,et al.  A flexible organic reflectance oximeter array , 2018, Proceedings of the National Academy of Sciences.

[31]  Dae-Hyeong Kim,et al.  Wearable Fall Detector using Integrated Sensors and Energy Devices , 2015, Scientific Reports.

[32]  Hong-Bo Sun,et al.  Mechanically robust stretchable organic optoelectronic devices built using a simple and universal stencil-pattern transferring technology , 2018, Light: Science & Applications.

[33]  Mathias Baumert,et al.  Conventional QT Variability Measurement vs. Template Matching Techniques: Comparison of Performance Using Simulated and Real ECG , 2012, PloS one.