A large trial of intravenous Conray 325 and Niopam 300 to assess immediate and delayed reactions.

The trial was designed as an investigation into the incidence of both immediate and delayed reactions to the intravenous administration of Conray 325 (sodium iothalamate) (844 patients) and Niopam 300 (iopamidol) (855 patients) for urographic examination. Information was obtained from questionnaires returned by patients about a week after their examination, with a response rate of 81%. Significant differences were found in the incidences of both types of reactions to the two media with respect to nausea and vomiting, arm pain, and taste in the mouth, which was commoner in patients receiving Conray 325, whereas the incidence of delayed skin rashes and parotid swelling was commoner with Niopam 300. The occurrence of a flu-like illness, so-called "iodism", was found to be equal for the two contrast media.

[1]  G L Wolf,et al.  Safer, more expensive iodinated contrast agents: how do we decide? , 1986, Radiology.

[2]  R. White,et al.  Liquid gold: low-osmolality contrast media. , 1986, Radiology.

[3]  P. Davies,et al.  Delayed reactions to urographic contrast media. , 1986, The British journal of radiology.

[4]  P. Davies,et al.  The old and the new: a study of five contrast media for urography. , 1985, The British journal of radiology.

[5]  R. Goldberg,et al.  Contrast induced sialadenitis--a case report. , 1984, The Journal of otolaryngology.

[6]  Spataro Rf.  Newer contrast agents for urography. , 1984 .

[7]  R. Grainger.  The clinical and financial implications of the low-osmolar radiological contrast media. , 1984, Clinical radiology.

[8]  F. Stacul,et al.  Iopamidol in urography , 1982, Urologic radiology.

[9]  M. Tweedie,et al.  The Current Status of Reactions to Intravenous Contrast Media , 1980, Investigative radiology.

[10]  G. Cummins,et al.  IODIDE MUMPS AFTER REPEATED EXPOSURE TO IODINATED CONTRAST MEDIA , 1980, The Lancet.

[11]  K. Kohri,et al.  Clinical Note: Bilateral Parotid Enlargement (“Iodide Mumps”) Following Excretory Urography , 1977 .

[12]  C. Taylor,et al.  Evanescent enlargement of salivary glands following tri-iodinated contrast media. , 1972, The British journal of radiology.

[13]  R. Brasch,et al.  Elevated salivary iodine and salivary gland enlargement due to iodinated contrast media. , 1971, The American journal of roentgenology, radium therapy, and nuclear medicine.

[14]  R. Koch,et al.  Parotid swelling with facial paralysis: a complication of intravenous urography. , 1969, Radiology.

[15]  J. Miller,et al.  Iodide mumps after intravenous urography. , 1956, The New England journal of medicine.