Transcriptional analysis of peripheral memory T cells reveals Parkinson’s disease-specific gene signatures
暂无分享,去创建一个
Bjoern Peters | A. Sette | D. Sulzer | D. Standaert | I. Litvan | J. Goldman | A. Frazier | C. L. Arlehamn | R. Alcalay | Rekha Dhanwani | J. R. Lima-Júnior | A. Amara | Gregory P. Williams | Yaqian Xu | J. Pham | A. Sethi | G. Williams
[1] M. Heneka,et al. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes , 2021, Cell.
[2] Samantha M. Carlisle,et al. Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease , 2021, NPJ Parkinson's disease.
[3] M. Tansey,et al. Is LRRK2 the missing link between inflammatory bowel disease and Parkinson’s disease? , 2021, NPJ Parkinson's disease.
[4] D. Tang,et al. Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome , 2021, Frontiers in Immunology.
[5] A. Desautels,et al. Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder , 2021, Neurology.
[6] D. Sulzer,et al. A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo , 2020, Proceedings of the National Academy of Sciences of the United States of America.
[7] M. Shaikh,et al. Fractalkine (CX3CL1) signaling and neuroinflammation in Parkinson's disease: Potential clinical and therapeutic implications. , 2020, Pharmacological research.
[8] S. Mallal,et al. α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson’s disease , 2020, Nature Communications.
[9] Fumito Ito,et al. CX3CR1-CD8+ T cells are critical in antitumor efficacy, but functionally suppressed in the tumor microenvironment. , 2020, JCI insight.
[10] F. Fiesel,et al. Autophagy in Parkinson's disease. , 2020, Journal of molecular biology.
[11] K. Jeong,et al. Chronic Infiltration of T Lymphocytes into the Brain in a Non-human Primate Model of Parkinson’s Disease , 2020, Neuroscience.
[12] Jiahong Lu,et al. Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models , 2020, Cell Death & Disease.
[13] Bjoern Peters,et al. Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease , 2019, Cell reports.
[14] Z. Asemi,et al. Aquaporin 4: A key player in Parkinson's disease , 2019, Journal of cellular physiology.
[15] S. Park,et al. Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease , 2019, Experimental neurobiology.
[16] I. Jonassen,et al. Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition , 2019, bioRxiv.
[17] N. Samadi,et al. Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems , 2019, Neuroscience Letters.
[18] E. Masliah,et al. Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment. , 2019, Free radical biology & medicine.
[19] D. Sulzer,et al. The physiological role of α‐synuclein and its relationship to Parkinson’s Disease , 2019, Journal of neurochemistry.
[20] P. van Endert. Faculty Opinions recommendation of Intestinal infection triggers Parkinson's disease-like symptoms in Pink1-/- mice. , 2019, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[21] S. Mallal,et al. Widespread Tau-Specific CD4 T Cell Reactivity in the General Population , 2019, The Journal of Immunology.
[22] H. McBride,et al. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice , 2019, Nature.
[23] M. Reinders,et al. Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease , 2019, bioRxiv.
[24] F. Blandini,et al. Role of Autophagy in Parkinson's Disease. , 2019, Current medicinal chemistry.
[25] C. Webber,et al. RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes , 2019, Neurobiology of Disease.
[26] J. Kordower,et al. Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys , 2019, The Journal of Immunology.
[27] S. Mallal,et al. Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles , 2019, The Journal of clinical investigation.
[28] R. Mailman,et al. Brain cholesterol metabolism and Parkinson's disease , 2019, Movement disorders : official journal of the Movement Disorder Society.
[29] S. Kügler,et al. β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration , 2019, Nature.
[30] Kieran R. Campbell,et al. Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes , 2019, Cell stem cell.
[31] Michael Johnson,et al. Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis , 2019, Trends in Neurosciences.
[32] P. J. Norris,et al. Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus–Specific CD8+ T Cells , 2018, The Journal of Immunology.
[33] Olga T. Schubert,et al. The in silico human surfaceome , 2018, Proceedings of the National Academy of Sciences.
[34] H. Ni,et al. The Role of LRRK2 in Neurodegeneration of Parkinson Disease , 2018, Current neuropharmacology.
[35] B. Becher,et al. T cells in patients with narcolepsy target self-antigens of hypocretin neurons , 2018, Nature.
[36] M. Dubinsky,et al. Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease , 2018, JAMA neurology.
[37] A. Stepan,et al. LRRK2 activation in idiopathic Parkinson’s disease , 2018, Science Translational Medicine.
[38] C. Tanner,et al. Prevalence of Parkinson’s disease across North America , 2018, npj Parkinson's Disease.
[39] A. Ballabio,et al. Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson's Disease-Related Neurodegeneration. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.
[40] Richard J Smeyne,et al. Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo , 2018, Brain : a journal of neurology.
[41] Julie G. Burel,et al. Transcriptomic Analysis of CD4+ T Cells Reveals Novel Immune Signatures of Latent Tuberculosis , 2018, The Journal of Immunology.
[42] Tomas Åkerud,et al. Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling , 2018, The Journal of Biological Chemistry.
[43] Bjoern Peters,et al. Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis , 2018, Science Immunology.
[44] S. Mallal,et al. T cells of Parkinson’s disease patients recognize α–synuclein peptides , 2017, Nature.
[45] S. Mallal,et al. T cells of Parkinson’s disease patients recognize α–synuclein peptides , 2017, Nature.
[46] C. Sankhla,et al. Oxidative stress and Parkinson's disease , 2017, Neurology India.
[47] L. Parnetti,et al. Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease , 2017, Molecular Neurodegeneration.
[48] C. Webber,et al. Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease , 2017, Human molecular genetics.
[49] U. V. von Andrian,et al. The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis. , 2016, Immunity.
[50] Daniela Berg,et al. Advances in markers of prodromal Parkinson disease , 2016, Nature Reviews Neurology.
[51] G. Gao,et al. Dysregulation of autophagy and mitochondrial function in Parkinson’s disease , 2016, Translational Neurodegeneration.
[52] L. Waldron,et al. Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array , 2015, Clinical Cancer Research.
[53] Ruedi Aebersold,et al. A Mass Spectrometric-Derived Cell Surface Protein Atlas , 2015, PloS one.
[54] B. Morrison,et al. Parkinson’s disease and enhanced inflammatory response , 2015, Experimental biology and medicine.
[55] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[56] L. Tan,et al. The role of the LRRK2 gene in Parkinsonism , 2014, Molecular Neurodegeneration.
[57] Daphne Koller,et al. Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes , 2014, Science.
[58] H. McBride,et al. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control , 2014, The EMBO journal.
[59] Åsa K. Björklund,et al. Full-length RNA-seq from single cells using Smart-seq2 , 2014, Nature Protocols.
[60] A. Björklund,et al. TFEB , 2013 .
[61] Wei Shi,et al. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features , 2013, Bioinform..
[62] O. Hwang. Role of Oxidative Stress in Parkinson's Disease , 2013, Experimental neurobiology.
[63] W. Poewe,et al. Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia , 2013, Glia.
[64] M. Schwartz,et al. Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates , 2013, Nature Reviews Immunology.
[65] J. Trojanowski,et al. Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice , 2012, Science.
[66] J. Vance. Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases , 2012, Disease Models & Mechanisms.
[67] D. Klionsky,et al. The role of autophagy in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.
[68] L. Stefanis. α-Synuclein in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.
[69] Jianhua Zhang,et al. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling , 2011, The Biochemical journal.
[70] Karen Marder,et al. Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population , 2011, BMC Medical Genetics.
[71] Andrea Ballabio,et al. TFEB Links Autophagy to Lysosomal Biogenesis , 2011, Science.
[72] Helga Thorvaldsdóttir,et al. Molecular signatures database (MSigDB) 3.0 , 2011, Bioinform..
[73] Robert A. Edwards,et al. Quality control and preprocessing of metagenomic datasets , 2011, Bioinform..
[74] J. Andersen,et al. Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo , 2010, Neuroscience Letters.
[75] M. Farrer,et al. LRRK2 and Parkinson disease. , 2010, Archives of neurology.
[76] Alvis Brazma,et al. A CD8 T cell transcription signature predicts prognosis in autoimmune disease , 2010, Nature Medicine.
[77] E. Masliah,et al. Phosphorylation of Synucleins by Members of the Polo-like Kinase Family* , 2009, The Journal of Biological Chemistry.
[78] Kenneth G. C. Smith,et al. Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis , 2009, Annals of the rheumatic diseases.
[79] M. Parihar,et al. Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells. , 2009, The international journal of biochemistry & cell biology.
[80] Gonçalo R. Abecasis,et al. The Sequence Alignment/Map format and SAMtools , 2009, Bioinform..
[81] R. Nussbaum,et al. Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. , 2008, Experimental cell research.
[82] M. Parihar,et al. Mitochondrial association of alpha-synuclein causes oxidative stress , 2008, Cellular and Molecular Life Sciences.
[83] Peter T Lansbury,et al. Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. , 2008, The Journal of clinical investigation.
[84] Wen-wei Li,et al. Localization of &agr;-synuclein to mitochondria within midbrain of mice , 2007, Neuroreport.
[85] N. Hattori,et al. Sept4, a Component of Presynaptic Scaffold and Lewy Bodies, Is Required for the Suppression of α-Synuclein Neurotoxicity , 2007, Neuron.
[86] Heikki Tanila,et al. Abnormal compartmentalization of norepinephrine in mouse dentate gyrus in α‐synuclein knockout and A30P transgenic mice , 2006, Journal of neurochemistry.
[87] Matthew J. Farrer,et al. LRRK2 in Parkinson's disease: protein domains and functional insights , 2006, Trends in Neurosciences.
[88] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[89] M. Beal,et al. Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons , 2005, Journal of neurochemistry.
[90] T. Dawson,et al. Parkin-associated Parkinson’s disease , 2004, Cell and Tissue Research.
[91] R. Ransohoff,et al. Three or more routes for leukocyte migration into the central nervous system , 2003, Nature Reviews Immunology.
[92] Christian Haass,et al. Subcellular Localization of Wild-Type and Parkinson's Disease-Associated Mutant α-Synuclein in Human and Transgenic Mouse Brain , 2000, The Journal of Neuroscience.
[93] M. Ashburner,et al. Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.
[94] M. L. Schmidt,et al. α-Synuclein in Lewy bodies , 1997, Nature.
[95] A. Torroni,et al. Mitochondrial oxidative phosphorylation defects in parkinson's disease , 1991, Annals of neurology.
[96] P. Mcgeer,et al. Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains , 1988, Neurology.
[97] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[98] L. Rochester,et al. Neurorehabilitation in Parkinson disease. , 2013, Handbook of clinical neurology.
[99] Stanley Fahn,et al. Neurodegeneration and neuroprotection in Parkinson disease , 2011, NeuroRX.
[100] T. Dawson,et al. The role of parkin in familial and sporadic Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.
[101] D. Price,et al. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. , 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[102] P. Jenner,et al. Oxidative stress in Parkinson's disease , 2003, Annals of neurology.
[103] M G Spillantini,et al. Alpha-synuclein in Lewy bodies. , 1997, Nature.