Asymptotic inference of causal effects with observational studies trimmed by the estimated propensity scores

&NA; Causal inference with observational studies often relies on the assumptions of unconfoundedness and overlap of covariate distributions in different treatment groups. The overlap assumption is violated when some units have propensity scores close to 0 or 1, so both practical and theoretical researchers suggest dropping units with extreme estimated propensity scores. However, existing trimming methods often do not incorporate the uncertainty in this design stage and restrict inference to only the trimmed sample, due to the nonsmoothness of the trimming. We propose a smooth weighting, which approximates sample trimming and has better asymptotic properties. An advantage of our estimator is its asymptotic linearity, which ensures that the bootstrap can be used to make inference for the target population, incorporating uncertainty arising from both design and analysis stages. We extend the theory to the average treatment effect on the treated, suggesting trimming samples with estimated propensity scores close to 1.

[1]  D. Rubin,et al.  The central role of the propensity score in observational studies for causal effects , 1983 .

[2]  Donald B. Rubin,et al.  Affinely Invariant Matching Methods with Ellipsoidal Distributions , 1992 .

[3]  J. Shao,et al.  The jackknife and bootstrap , 1996 .

[4]  J. Hahn On the Role of the Propensity Score in Efficient Semiparametric Estimation of Average Treatment Effects , 1998 .

[5]  G. Imbens,et al.  Efficient Estimation of Average Treatment Effects Using the Estimated Propensity Score , 2000 .

[6]  G. Imbens,et al.  Efficient Estimation of Average Treatment Effects Using the Estimated Propensity Score , 2002 .

[7]  J. Vincent,et al.  Anemia and blood transfusion in critically ill patients. , 2002, JAMA.

[8]  Mortality Benefit of Immediate Revascularization of Acute ST-Segment Elevation Myocardial Infarction in Patients With Contraindications to Thrombolytic Therapy: A Propensity Analysis , 2003 .

[9]  J. Robins,et al.  Doubly Robust Estimation in Missing Data and Causal Inference Models , 2005, Biometrics.

[10]  J. Robins,et al.  Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. , 2006, American journal of epidemiology.

[11]  Gary King,et al.  The Dangers of Extreme Counterfactuals , 2006, Political Analysis.

[12]  Joseph Kang,et al.  Demystifying Double Robustness: A Comparison of Alternative Strategies for Estimating a Population Mean from Incomplete Data , 2007, 0804.2958.

[13]  G. Imbens,et al.  Matching on the Estimated Propensity Score , 2009 .

[14]  Richard K. Crump,et al.  Dealing with limited overlap in estimation of average treatment effects , 2009 .

[15]  Elizabeth A Stuart,et al.  Improving propensity score weighting using machine learning , 2010, Statistics in medicine.

[16]  Shakeeb Khan,et al.  Irregular Identification, Support Conditions, and Inverse Weight Estimation , 2010 .

[17]  J. Kmenta Mostly Harmless Econometrics: An Empiricist's Companion , 2010 .

[18]  Dylan S. Small,et al.  Defining the Study Population for an Observational Study to Ensure Sufficient Overlap: A Tree Approach , 2011 .

[19]  Brian K. Lee,et al.  Weight Trimming and Propensity Score Weighting , 2011, PloS one.

[20]  Kristin E. Porter,et al.  Diagnosing and responding to violations in the positivity assumption , 2012, Statistical methods in medical research.

[21]  Dylan S. Small,et al.  Calibrating Sensitivity Analyses to Observed Covariates in Observational Studies , 2013, Biometrics.

[22]  Fan Li,et al.  Do debit cards increase household spending? Evidence from a semiparametric causal analysis of a survey , 2014, 1409.2441.

[23]  Dylan S. Small,et al.  Discrete Optimization for Interpretable Study Populations and Randomization Inference in an Observational Study of Severe Sepsis Mortality , 2014, 1411.4873.

[24]  Qingyuan Zhao,et al.  Double Robustness for Causal Effects via Entropy Balancing , 2015 .

[25]  D. Rubin,et al.  Causal Inference for Statistics, Social, and Biomedical Sciences: A General Method for Estimating Sampling Variances for Standard Estimators for Average Causal Effects , 2015 .

[26]  Y. Matsuyama,et al.  Brief Report: Doubly Robust Estimation of Standardized Risk Difference and Ratio in the Exposed Population , 2015, Epidemiology.

[27]  Guido W. Imbens,et al.  Matching Methods in Practice: Three Examples , 2014, The Journal of Human Resources.

[28]  Jared K Lunceford,et al.  Stratification and weighting via the propensity score in estimation of causal treatment effects: a comparative study. , 2017, Statistics in medicine.

[29]  Kari Lock Morgan,et al.  Balancing Covariates via Propensity Score Weighting , 2014, 1609.07494.