Perineural dexamethasone and multimodal perineural analgesia: how much is too much?

while 8 mg given perineurally (in combination with local anesthetics) may actually be hyperalgesic. In a recent translational-bench study, Kolarczyk and Williams reported on transient heat hyperalgesia 3 hours after ropivacaine sciatic nerve block in rats, when compared with saline vehicle controls. We pos-tulated 15 that local anesthetics may be implicated in a clinical phenomenon that we previously described as “rebound pain.” In rat experiments occurred simultaneously, 17

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