Label-Free Highly Sensitive Hybrid Plasmonic Biosensor for the Detection of DNA Hybridization

A highly sensitive hybrid plasmonic slot-waveguide (HPSW) biosensor based on silicon-on-insulator is proposed and analyzed for DNA hybridization detection. The reported design is based on increasing the light interaction with the sensing region by using slot waveguide with plasmonic material. Due to the high index contrast and plasmonic effect, an ultrahigh optical confinement is achieved in the low-index regions, which enables the detection of the smallest change in the analyte refractive index with high sensitivity. The normalized power confinement, power density, and effective index of the supported modes by the HPSW are analyzed to achieve high-power confinement through the suggested biosensor and hence high sensitivity can be obtained. The HPSW is also incorporated with straight slotted resonator to calculate the sensitivity of the proposed design. The simulation results are calculated using full vectorial finite element method. The reported biosensor has high sensitivity of 1890.4 nm/RIU (refractive index unit), which is the highest in the literature to the best of our knowledge with a detection limit of 2.65 × 10 –6 RIU.

[1]  B. Luff,et al.  Integrated-optical directional coupler biosensor. , 1996, Optics letters.

[2]  K. Lance Kelly,et al.  Chain Length Dependence and Sensing Capabilities of the Localized Surface Plasmon Resonance of Silver Nanoparticles Chemically Modified with Alkanethiol Self-Assembled Monolayers , 2001 .

[3]  Alexander Papra,et al.  Characterization of ultrathin poly(ethylene glycol) monolayers on silicon substrates , 2001 .

[4]  B. M. A. Rahman,et al.  Full vectorial finite element modeling of novel polarization rotators , 2003 .

[5]  V. Singer,et al.  Fluorescent DNA hybridization probe preparation using amine modification and reactive dye coupling. , 2004, BioTechniques.

[6]  A. Driessen,et al.  Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors , 2005, IEEE Journal of Selected Topics in Quantum Electronics.

[7]  Harald Ditlbacher,et al.  Dielectric stripes on gold as surface plasmon waveguides , 2006 .

[8]  J. Jensen,et al.  Photonic crystal fiber long-period gratings for biochemical sensing. , 2006, Optics express.

[9]  R. Baets,et al.  Silicon-on-insulator microring resonator for biosensing , 2007 .

[10]  R. Baets,et al.  Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. , 2007, Optics express.

[11]  Francesco Dell'Olio,et al.  Optical sensing by optimized silicon slot waveguides. , 2007, Optics express.

[12]  Alexey V. Krasavin,et al.  Passive photonic elements based on dielectric-loaded surface plasmon polariton waveguides , 2007 .

[13]  Alexey V. Krasavin,et al.  Three-dimensional numerical modeling of photonic integration with dielectric-loaded SPP waveguides , 2008 .

[14]  Amadeu Griol,et al.  Label-free optical biosensing with slot-waveguides. , 2008, Optics letters.

[15]  Vittorio M. N. Passaro,et al.  Efficient Chemical Sensing by Coupled Slot SOI Waveguides , 2009, Sensors.

[16]  Yikai Su,et al.  Sensitive label-free and compact biosensor based on concentric silicon-on-insulator microring resonators. , 2009, Applied optics.

[17]  P. Bienstman,et al.  Label-Free Biosensing With a Slot-Waveguide-Based Ring Resonator in Silicon on Insulator , 2009, IEEE Photonics Journal.

[18]  Theoretical Investigation of an Interferometer-type Plasmonic Biosensor Using a Metal-insulator-silicon Waveguide , 2010 .

[19]  Graham Town,et al.  Multi-channel directional coupler as an evanescent field optical sensor , 2010 .

[20]  S. Obayya,et al.  Novel fast photonic crystal multiplexer-demultiplexer switches , 2011 .

[21]  Xinwan Li,et al.  Miniature Microring Resonator Sensor Based on a Hybrid Plasmonic Waveguide , 2011, Sensors.

[22]  M. Rajarajan,et al.  Label-free slot-waveguide biosensor for the detection of DNA hybridization. , 2012, Applied optics.

[23]  J. Aitchison,et al.  Dual Polarization Measurements in the Hybrid Plasmonic Biosensors , 2013, Plasmonics.

[24]  A. M. Heikal,et al.  Improved Trenched Channel Plasmonic Waveguide , 2013, Journal of Lightwave Technology.

[25]  Mohamed Farhat O. Hameed,et al.  Proposal of an Ultracompact CMOS-Compatible TE-/TM-Pass Polarizer Based on SoI Platform , 2014, IEEE Photonics Technology Letters.

[26]  Iman Khodadad,et al.  Optimization of multiple-slot waveguides for biochemical sensing. , 2014, Applied optics.

[27]  T. Dar.  Numerical characterisation of label free optical biosensors , 2015 .

[28]  B. Rahman,et al.  Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization. , 2015, Applied optics.

[29]  Lech Wosinski,et al.  High-sensitivity liquid refractive-index sensor based on a Mach-Zehnder interferometer with a double-slot hybrid plasmonic waveguide. , 2015, Optics express.

[30]  Mohamed Farhat O. Hameed,et al.  Highly Sensitive Plasmonic Photonic Crystal Temperature Sensor Filled With Liquid Crystal , 2016, IEEE Photonics Technology Letters.

[31]  Meng Zhang,et al.  Hybrid plasmonic microcavity with an air-filled gap for sensing applications , 2016 .

[32]  Mohamed Farhat O. Hameed,et al.  Multichannel photonic crystal fiber surface plasmon resonance based sensor , 2016 .

[33]  Mohamed Farhat O. Hameed,et al.  Self-Calibration Highly Sensitive Photonic Crystal Fiber Biosensor , 2016, IEEE Photonics Journal.

[34]  Byoungho Lee,et al.  Numerical study on refractive index sensor based on hybrid-plasmonic mode , 2017, 2017 25th Optical Fiber Sensors Conference (OFS).

[35]  A Metal-Assisted Silicon Slot Waveguide for Highly Sensitive Gas Detection , 2017, IEEE Photonics Journal.

[36]  B. M. A. Rahman,et al.  An Innovative Straight Resonator Incorporating a Vertical Slot as an Efficient Bio-Chemical Sensor , 2017, IEEE Journal of Selected Topics in Quantum Electronics.

[37]  V. Shalaev,et al.  Hybrid plasmonic waveguides formed by metal coating of dielectric ridges. , 2017, Optics express.