Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets

[1]  K. Schalinske,et al.  Tissue‐specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat , 2012, Diabetes/metabolism research and reviews.

[2]  E. Rimm,et al.  Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease , 2011, Circulation. Cardiovascular genetics.

[3]  Wen-Harn Pan,et al.  A Genome-Wide Association Study Reveals a Quantitative Trait Locus of Adiponectin on CDH13 That Predicts Cardiometabolic Outcomes , 2011, Diabetes.

[4]  Chengyu Liu,et al.  Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusion injury. , 2011, American journal of physiology. Heart and circulatory physiology.

[5]  Bin Tian,et al.  Comparative Analysis of mRNA Isoform Expression in Cardiac Hypertrophy and Development Reveals Multiple Post-Transcriptional Regulatory Modules , 2011, PloS one.

[6]  Manuel A. R. Ferreira,et al.  Meta‐analysis of heterogeneous data sources for genome‐scale identification of risk genes in complex phenotypes , 2011, Genetic epidemiology.

[7]  C Charles Gu,et al.  Variable set enrichment analysis in genome-wide association studies , 2011, European Journal of Human Genetics.

[8]  Y. Li,et al.  Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain. , 2010, Free radical biology & medicine.

[9]  Thomas Meitinger,et al.  Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution , 2010, Nature Genetics.

[10]  T. Beaty,et al.  Adiponectin concentrations: a genome-wide association study. , 2010, American journal of human genetics.

[11]  Ayellet V. Segrè,et al.  Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits , 2010, PLoS genetics.

[12]  E. Eskin,et al.  Genome-wide case/control studies in hypertension: only the ‘tip of the iceberg’ , 2010, Journal of hypertension.

[13]  Yongmei Liu,et al.  Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study , 2010, Mediators of inflammation.

[14]  J. Obata,et al.  Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury. , 2010, Cardiovascular Research.

[15]  Stacey Knight,et al.  Pedigree association: assigning individual weights to pedigree members for genetic association analysis , 2009, BMC proceedings.

[16]  Matty P Weijenberg,et al.  Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer , 2009, Cancer Epidemiology, Biomarkers & Prevention.

[17]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[18]  H. Yoshida,et al.  Association of genetic variants with myocardial infarction in Japanese individuals with metabolic syndrome. , 2009, Atherosclerosis.

[19]  H. Cordell.  Detecting gene–gene interactions that underlie human diseases , 2009, Nature Reviews Genetics.

[20]  E. Steyerberg,et al.  Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. , 2009, Atherosclerosis.

[21]  Yongmei Liu,et al.  Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. , 2009, Atherosclerosis.

[22]  Christian Gieger,et al.  Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations , 2009, Human molecular genetics.

[23]  T. Hudson,et al.  Genetic Variants Associated With Myocardial Infarction Risk Factors in Over 8000 Individuals From Five Ethnic Groups: The INTERHEART Genetics Study , 2009, Circulation. Cardiovascular genetics.

[24]  B. Maher.  Personal genomes: The case of the missing heritability , 2008, Nature.

[25]  N. Schork,et al.  Pathway analysis of seven common diseases assessed by genome-wide association. , 2008, Genomics.

[26]  I. König,et al.  Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. , 2008, Clinical science.

[27]  L. Rallidis,et al.  Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction. , 2008, Atherosclerosis.

[28]  H. Weissbach,et al.  MsrA protects cardiac myocytes against hypoxia/reoxygenation induced cell death. , 2008, Biochemical and biophysical research communications.

[29]  Simon J. Walker,et al.  Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction , 2008, Hypertension.

[30]  D. Couper,et al.  Cyclooxygenase Polymorphisms and Risk of Cardiovascular Events: The Atherosclerosis Risk in Communities (ARIC) Study , 2008, Clinical pharmacology and therapeutics.

[31]  R. Myers,et al.  Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. , 2007, American heart journal.

[32]  Kai Wang,et al.  Pathway-based approaches for analysis of genomewide association studies. , 2007, American journal of human genetics.

[33]  Sudha Seshadri,et al.  The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports , 2007, BMC Medical Genetics.

[34]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[35]  J. O’Connell,et al.  Accounting for Relatedness in Family Based Genetic Association Studies , 2007, Human Heredity.

[36]  S. Holland,et al.  Critical Role of the NAD(P)H Oxidase Subunit p47phox for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction , 2007, Circulation research.

[37]  Borut Peterlin,et al.  Association of Vascular Endothelial Growth Factor Gene Polymorphism with Myocardial Infarction in Patients with Type 2 Diabetes , 2007, Cardiology.

[38]  M. Xiong,et al.  Test for interaction between two unlinked loci. , 2006, American journal of human genetics.

[39]  N. Cook,et al.  Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. , 2006, Clinical chemistry.

[40]  P. Ridker,et al.  Polymorphisms of prostaglandin‐endoperoxide synthase 2 gene, and prostaglandin‐E receptor 2 gene, C‐reactive protein concentrations and risk of atherothrombosis: a nested case–control approach , 2006, Journal of thrombosis and haemostasis : JTH.

[41]  S. Lewis,et al.  Meta-analysis of MTHFR 677C→ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? , 2005, BMJ : British Medical Journal.

[42]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  M. Rose-Zerilli,et al.  VEGF polymorphisms and severity of atherosclerosis , 2005, Journal of Medical Genetics.

[44]  H. Blom,et al.  The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. , 2003, Thrombosis research.

[45]  R. Rozen,et al.  Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. , 2003, Atherosclerosis.

[46]  K. Kugiyama,et al.  Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. , 2003, Journal of the American College of Cardiology.

[47]  W. Willett,et al.  Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians. , 1996, Circulation.

[48]  J. Laragh,et al.  Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. , 1991, Annals of internal medicine.

[49]  D E Manyari,et al.  Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. , 1990, The New England journal of medicine.

[50]  B Horwitz,et al.  Simulating functional interactions in the brain: a model for examining correlations between regional cerebral metabolic rates. , 1990, International journal of bio-medical computing.

[51]  D. Kleinbaum,et al.  Applied Regression Analysis and Other Multivariate Methods , 1978 .

[52]  M. Connelly,et al.  Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. , 2011, Human molecular genetics.

[53]  Simon J. Walker,et al.  Involvement of Nox 2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction , 2008 .

[54]  N. Ilhan,et al.  The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels. , 2008, Archives of medical research.