Processing of semantic categorical and associative relations: an ERP mapping study.

Brain imaging studies have repeatedly shown a dominant involvement of the left hemisphere (LH) in the processing of semantic information. However, some behavioural studies have suggested that the right hemisphere (RH) also processes lexico-semantic information although in a qualitatively different way. More specifically, it has been proposed that the LH shows a greater sensitivity to categorical (CR, or intraconceptual) relationships, while the RH appears more sensitive to associative (AR, or interconceptual) ones. Using semantically unrelated and related word pairs comprised of CR and AR, our aim in this study was to verify the involvement of the RH in the processing of associative relationships. Strength-independent topographical analysis of ERP map series using temporal segmentation procedures showed the same sequence of eight stable map segments in CR and AR conditions. Statistical analysis revealed no difference between conditions either in terms of duration or in terms of time of occurrence of the segmentation maps. However, field strength comparisons between the two conditions using the global field power measure at each time point revealed higher field strength in CR than in AR condition between 300 and 330 ms. Distributed source localisation showed a similar pattern of activation during this time period, involving predominantly left frontal regions. Nevertheless, the strength of the source found in the left medial frontal gyrus differed between CR than AR conditions, thus explaining the differences observed in field strength. Our data suggest that the processing of CR and AR words depend on the same neural network in the LH.

[1]  R W Cox,et al.  Language processing is strongly left lateralized in both sexes. Evidence from functional MRI. , 1999, Brain : a journal of neurology.

[2]  D. Lehmann,et al.  Principles of spatial analysis , 1987 .

[3]  M. Kutas,et al.  Event-related brain potentials to semantically inappropriate and surprisingly large words , 1980, Biological Psychology.

[4]  Gina Rippon,et al.  Mapping dissociations in verb morphology , 2001, Trends in Cognitive Sciences.

[5]  M. Abernethy,et al.  Associative priming in the hemispheres as a function of SOA , 1993, Neuropsychologia.

[6]  S. Morand,et al.  Electric source imaging of human brain functions , 2001, Brain Research Reviews.

[7]  U. Nocentini,et al.  The effects of left- versus right-hemisphere lesions on the sensitivity to intra- and interconceptual semantic relationships , 2001, Neuropsychologia.

[8]  S. Gonzalez-Andino,et al.  A critical analysis of linear inverse solutions to the neuroelectromagnetic inverse problem , 1998, IEEE Transactions on Biomedical Engineering.

[9]  D. V. von Cramon,et al.  Language dominance assessment by means of fMRI: Contributions from task design, performance, and stimulus modality , 2001, Journal of magnetic resonance imaging : JMRI.

[10]  C M Michel,et al.  The time course of semantic category processing in the cerebral hemispheres: an electrophysiological study. , 2001, Brain research. Cognitive brain research.

[11]  Dietrich Lehmann,et al.  Mapping event-related brain potential microstates to sentence endings , 2005, Brain Topography.

[12]  G. Mangun,et al.  Estimation of interpolation errors in scalp topographic mapping. , 1996, Electroencephalography and clinical neurophysiology.

[13]  Allan Collins,et al.  A spreading-activation theory of semantic processing , 1975 .

[14]  C. C. Wood,et al.  Event-related potentials, lexical decision and semantic priming. , 1985, Electroencephalography and clinical neurophysiology.

[15]  Christine Chiarello,et al.  Lexical judgements after right- or left-hemisphere injury , 1986, Neuropsychologia.

[16]  Mark D'Esposito,et al.  Cognitive Association Formation in Human Memory Revealed by Spatiotemporal Brain Imaging , 2001, Neuron.

[17]  P. Mousty,et al.  Brulex: une base de donne 'es lexicales informatise 'e pour le franc?ais e 'crit et parle , 1990 .

[18]  Richard S. J. Frackowiak,et al.  The anatomy of phonological and semantic processing in normal subjects. , 1992, Brain : a journal of neurology.

[19]  Christoph M. Michel,et al.  Early Cortical Distinction between Memories that Pertain to Ongoing Reality and Memories that Don't , 2002 .

[20]  Dietrich Lehmann,et al.  Microstates in Language-Related Brain Potential Maps Show Noun–Verb Differences , 1996, Brain and Language.

[21]  D. Lehmann,et al.  Segmentation of brain electrical activity into microstates: model estimation and validation , 1995, IEEE Transactions on Biomedical Engineering.

[22]  Christoph M. Michel,et al.  New insights into the Stroop effect : a spatiotemporal analysis of electric brain activity , 2000 .

[23]  M. Rugg,et al.  Event-related potentials and the semantic matching of pictures , 1990, Brain and Cognition.

[24]  C. Michel,et al.  Noninvasive Localization of Electromagnetic Epileptic Activity. I. Method Descriptions and Simulations , 2004, Brain Topography.

[25]  Jemett L. Desmond,et al.  Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[26]  C C Wood,et al.  Mapping function in the human brain with magnetoencephalography, anatomical magnetic resonance imaging, and functional magnetic resonance imaging. , 1995, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[27]  G. Pfurtscheller.  Handbook of electroencephalography and clinical neurophysiology , 1978 .

[28]  M. Koivisto,et al.  Lateralized free-association priming: Implications for the hemispheric organization of semantic memory , 1995, Neuropsychologia.

[29]  Jules Davidoff,et al.  The dual brain D. Frank Benson and Eran Zaidel (eds.), (Guilford Press, New York, 1985) pp. 430, £34 , 1987, Biological Psychology.

[30]  C. Price,et al.  Functional Neuroanatomy of the Semantic System: Divisible by What? , 1998, Journal of Cognitive Neuroscience.

[31]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[32]  T Landis,et al.  Spatio-temporal analysis of electric brain activity during semantic and phonological word processing. , 1998, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[33]  C. Burgess,et al.  Semantic and associative priming in the cerebral hemispheres: Some words do, some words don't … sometimes, some places , 1990, Brain and Language.

[34]  F Lazeyras,et al.  Language representation in a patient with a dominant right hemisphere: fMRI evidence for an intrahemispheric reorganisation , 2001, Neuroreport.

[35]  C M Michel,et al.  Semantic Category and Rhyming Processing in the Left and Right Cerebral Hemisphere , 2000, Laterality.

[36]  Stephen M. Rao,et al.  Human Brain Language Areas Identified by Functional Magnetic Resonance Imaging , 1997, The Journal of Neuroscience.

[37]  P. Holcomb.  Automatic and attentional processing: An event-related brain potential analysis of semantic priming , 1988, Brain and Language.

[38]  W Skrandies,et al.  Evoked potential correlates of semantic meaning--A brain mapping study. , 1998, Brain research. Cognitive brain research.

[39]  Asaid Khateb,et al.  Neural processing of illusory and real contours revealed by high‐density ERP mapping , 2002, Neuroreport.

[40]  Christoph M. Michel,et al.  Dynamics of Brain Activation During an Explicit Word and Image Recognition Task: An Electrophysiological Study , 2004, Brain Topography.

[41]  Christoph M. Michel,et al.  Segregated Processing of Auditory Motion and Auditory Location: An ERP Mapping Study , 2002, NeuroImage.

[42]  Colin M. Brown,et al.  Lexical-semantic event-related potential effects in patients with left hemisphere lesions and aphasia, and patients with right hemisphere lesions without aphasia. , 1996, Brain : a journal of neurology.

[43]  M A Bobes,et al.  Brain potentials and the availability of semantic and phonological codes over time , 1994, Neuroreport.

[44]  M. Posner,et al.  Positron Emission Tomographic Studies of the Processing of Singe Words , 1989, Journal of Cognitive Neuroscience.

[45]  T Landis,et al.  Electrophysiological evidence for fast visual processing through the human koniocellular pathway when stimuli move. , 2000, Cerebral cortex.

[46]  M. Rugg,et al.  Event-related potentials and the semantic matching of faces , 1989, Neuropsychologia.

[47]  Richard S. J. Frackowiak,et al.  Functional anatomy of a common semantic system for words and pictures , 1996, Nature.

[48]  D. Lehmann,et al.  Reference-free identification of components of checkerboard-evoked multichannel potential fields. , 1980, Electroencephalography and clinical neurophysiology.

[49]  John Polich,et al.  Semantic categorization and event-related potentials , 1985, Brain and Language.

[50]  D Lehmann,et al.  Event-related electric microstates of the brain differ between words with visual and abstract meaning. , 1998, Electroencephalography and clinical neurophysiology.

[51]  P. Viviani,et al.  Internally driven vs. externally cued movement selection: a study on the timing of brain activity. , 2000, Brain research. Cognitive brain research.

[52]  C. Michel,et al.  Unraveling the cerebral dynamics of mental imagery , 1997, Human brain mapping.

[53]  Theodor Landis,et al.  Hemispheric dissociation in judging semantic relations: Complementarity for close and distant associates , 1992, Brain and Language.

[54]  E. Drews,et al.  Qualitatively different organizational structures of lexical knowledge in the left and right hemisphere , 1987, Neuropsychologia.

[55]  M. Abernethy,et al.  Semantic category priming in the left cerebral hemisphere , 1996, Neuropsychologia.