A Self-ensembling Framework for Semi-supervised Knee Cartilage Defects Assessment with Dual-Consistency

Knee osteoarthritis (OA) is one of the most common musculoskeletal disorders and requires early-stage diagnosis. Nowadays, the deep convolutional neural networks have achieved greatly in the computer-aided diagnosis field. However, the construction of the deep learning models usually requires great amounts of annotated data, which is generally high-cost. In this paper, we propose a novel approach for knee cartilage defects assessment, including severity classification and lesion localization. This can be treated as a subtask of knee OA diagnosis. Particularly, we design a self-ensembling framework, which is composed of a student network and a teacher network with the same structure. The student network learns from both labeled data and unlabeled data and the teacher network averages the student model weights through the training course. A novel attention loss function is developed to obtain accurate attention masks. With dual-consistency checking of the attention in the lesion classification and localization, the two networks can gradually optimize the attention distribution and improve the performance of each other, whereas the training relies on partially labeled data only and follows the semi-supervised manner. Experiments show that the proposed method can significantly improve the self-ensembling performance in both knee cartilage defects classification and localization, and also greatly reduce the needs of annotated data.

[1]  M. Karsdal,et al.  Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future. , 2016, Osteoarthritis and cartilage.

[2]  Chi-Wing Fu,et al.  Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation , 2019, MICCAI.

[3]  H. Genant,et al.  Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. , 2004, Osteoarthritis and cartilage.

[4]  Joseph Antony,et al.  Quantifying radiographic knee osteoarthritis severity using deep convolutional neural networks , 2016, 2016 23rd International Conference on Pattern Recognition (ICPR).

[5]  F. Liu,et al.  Deep Learning Approach for Evaluating Knee MR Images: Achieving High Diagnostic Performance for Cartilage Lesion Detection. , 2018, Radiology.

[6]  Gang Sun,et al.  Squeeze-and-Excitation Networks , 2017, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[7]  Harri Valpola,et al.  Weight-averaged consistency targets improve semi-supervised deep learning results , 2017, ArXiv.

[8]  Qian Wang,et al.  Weakly Supervised Segmentation Framework with Uncertainty: A Study on Pneumothorax Segmentation in Chest X-ray , 2019, MICCAI.

[9]  Li Fei-Fei,et al.  ImageNet: A large-scale hierarchical image database , 2009, CVPR.

[10]  Yun Fu,et al.  Tell Me Where to Look: Guided Attention Inference Network , 2018, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[11]  Thomas Brox,et al.  U-Net: Convolutional Networks for Biomedical Image Segmentation , 2015, MICCAI.