Chinese a Nti鄄 Cancer a Ssociation

Lung cancer is responsible for 29% of cancer deaths in the United States and has very low 5-year survival rates of approximately 11% in men and 15% in women. Although the early diagnosis of lung cancer may increase the survival rate with adequate treatment, advanced lung cancers are often metastasized and receive limited benefit from therapeutic regimens. As conventional treatments for lung cancer reach their limitations, researchers have attempted to discover novel drug therapies aimed at specific targets contributing to the progression of tumorigenesis. Recent advances in systems biology have enabled the molecular biology of lung Carcinogenesis to be elucidated. Our understanding of the physiologic processes of tumor development provide a means to design more effective and specific drugs with less toxicity, thereby accelerating the delivery of new drug therapies to the patient's bedside.

[1]  L. Stitt,et al.  Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[2]  T. Sekiya,et al.  Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. , 1990, Oncogene.

[3]  Ming You,et al.  Wildtype Kras2 can inhibit lung carcinogenesis in mice , 2001, Nature Genetics.

[4]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[5]  P. Ma.  Personalized targeted therapy in advanced non–small cell lung cancer , 2012, Cleveland Clinic Journal of Medicine.

[6]  S. Lippard,et al.  Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. Plummer,et al.  International agency for research on cancer. , 2020, Archives of pathology.

[8]  Hongyu Zhou,et al.  Advances in preclinical small molecules for the treatment of NSCLC , 2009, Expert opinion on therapeutic patents.

[9]  I. Bellenis,et al.  Institutional report - Thoracic oncologic Low incidence of bronchopleural fistula after pneumonectomy for lung cancer , 2009 .

[10]  S. Cohen,et al.  Epidermal growth factor , 1972, The Journal of investigative dermatology.

[11]  G. Tortora,et al.  A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[12]  P. Ma,et al.  Anti-MET targeted therapy has come of age: the first durable complete response with MetMAb in metastatic gastric cancer. , 2011, Cancer discovery.

[13]  D. Jablons,et al.  The role of stem cells in airway repair: implications for the origins of lung cancer , 2012, Chinese journal of cancer.

[14]  S. Leng,et al.  EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. , 2011, Cancer research.

[15]  R. Makuch,et al.  Chemotherapy alone or chemotherapy with chest radiation therapy in limited stage small cell lung cancer. A prospective, randomized trial. , 1987, Annals of internal medicine.

[16]  W. Birchmeier,et al.  Met, metastasis, motility and more , 2003, Nature Reviews Molecular Cell Biology.

[17]  M. To,et al.  The genetics and biology of KRAS in lung cancer , 2013, Chinese journal of cancer.

[18]  Brian H. Dunford-Shore,et al.  Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.

[19]  D. Jablons,et al.  Lung cancer therapeutics that target signaling pathways: an update , 2010, Expert review of respiratory medicine.

[20]  H. Espejo,et al.  [Gastric cancer]. , 1996, Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru.