PHOTOSENSITIZERS: THERAPY AND DETECTION OF MALIGNANT TUMORS

Abstract. Advances in the use of photosensitizers for detection and treatment of malignant tumors during the previous reviews in this journal have been mainly in the areas of development of potentially useful new photosensitizers (e.g. phthalocyanines and chlorins), further understanding of the mechanisms of photodynamic therapy (PDT), and in dosimetry of light delivery in tissue. Perhaps the most significant advance during the past year has been the initiation of Phase III clinical trials of PDT vs standard therapy in treatment of superficial bladder cancer and obstructive endobronchial tumors. In the final analysis, only such clinical trials can determine the future of this new modality for cancer treatment.

[1]  M C Berenbaum,et al.  meso-Tetra(hydroxyphenyl)porphyrins, a new class of potent tumour photosensitisers with favourable selectivity. , 1986, British Journal of Cancer.

[2]  T. Dougherty,et al.  Photoradiation therapy in advanced carcinoma of the trachea and bronchus. , 1984, Chest.

[3]  T. Mang,et al.  Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy. , 1985, Cancer research.

[4]  D. Kessel,et al.  Localization and photosensitization of murine tumors in vivo and in vitro by a chlorin-porphyrin ester. , 1986, Cancer research.

[5]  R. Keck,et al.  Morphological study of the combined effect of purpurin derivatives and light on transplantable rat bladder tumors. , 1987, Cancer research.

[6]  D. Kessel.  SITES OF PHOTOSENSITIZATION BY DERIVATIVES OF HEMATOPORPHYRIN , 1986, Photochemistry and photobiology.

[7]  T J Dougherty,et al.  Interaction of hyperthermia and photoradiation therapy. , 1984, Radiation research.

[8]  E. Ben-hur,et al.  PHOTOSENSITIZED INACTIVATION OF CHINESE HAMSTER CELLS BY PHTHALOCYANINES , 1985, Photochemistry and photobiology.

[9]  P A Cowled,et al.  COMPARISON OF THE EFFICACY OF PULSED AND CONTINUOUS‐WAVE RED LASER LIGHT IN INDUCTION OF PHOTOCYTOTOXICITY BY HAEMATOPORPHYRIN DERIVATIVE , 1984, Photochemistry and photobiology.

[10]  J. Moan,et al.  The main photosensitizing components of hematoporphyrin derivative. , 1982, Cancer letters.

[11]  B. Ward,et al.  The treatment of vaginal recurrences of gynecologic malignancy with phototherapy following hematoporphyrin derivative pretreatment. , 1982, American journal of obstetrics and gynecology.

[12]  E. Ben-hur,et al.  Photodynamic treatment of transplantable bladder tumors in rodents after pretreatment with chloroaluminum tetrasulfophthalocyanine. , 1986, The Journal of urology.

[13]  L. Grossweiner,et al.  BINDING OF HEMATOPORPHYRIN DERIVATIVE TO HUMAN SERUM ALBUMIN , 1984, Photochemistry and photobiology.

[14]  A. D. Ward,et al.  PHOTOTHERAPY OF HUMAN TUMOURS USING HAEMATOPORPHYRIN DERIVATIVE , 1980, The Medical journal of Australia.

[15]  H. Kato,et al.  Photoradiation therapy with hematoporphyrin derivative in early and stage 1 lung cancer. , 1984, Chest.

[16]  T. Dougherty.  HEMATOPORPHYRIN AS A PHOTOSENSITIZER OF TUMORS * , 1983, Photochemistry and photobiology.

[17]  E. Ben-hur,et al.  The phthalocyanines: a new class of mammalian cells photosensitizers with a potential for cancer phototherapy. , 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[18]  J Moan,et al.  Uptake of the components of hematoporphyrin derivative by cells and tumours. , 1983, Cancer letters.

[19]  R. Langlois,et al.  BIOLOGICAL ACTIVITIES OF PHTHALOCYANINES—V. PHOTODYNAMIC THERAPY OF EMT‐6 MAMMARY TUMORS IN MICE WITH SULFONATED PHTHALOCYANINES , 1987, Photochemistry and photobiology.

[20]  J Moan,et al.  The binding of dihematoporphyrin ether (photofrin II) to human serum albumin. , 1985, Clinica chimica acta; international journal of clinical chemistry.

[21]  E. Reddi,et al.  Effect of hematoporphyrin and red light on AH-130 solid tumors in rats. , 1983, Acta radiologica. Oncology.

[22]  T. Dougherty,et al.  Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue. , 1979, Cancer research.

[23]  P. D. Smith,et al.  Photodynamic therapy with porphyrin and phthalocyanine sensitisation: quantitative studies in normal rat liver. , 1986, British Journal of Cancer.

[24]  J Moan,et al.  Oxygen dependence of the photosensitizing effect of hematoporphyrin derivative in NHIK 3025 cells. , 1985, Cancer research.

[25]  M. Berns,et al.  Photoradiation therapy of head and neck cancer , 1984, Progress in clinical and biological research.

[26]  A. Wahl,et al.  Inhibition of mammalian DNA polymerases by hematoporphyrin derivative and photoradiation. , 1986, Cancer research.

[27]  M R Arnfield,et al.  Treatment of Dunning R3327-AT rat prostate tumors with photodynamic therapy in combination with misonidazole. , 1986, Cancer research.

[28]  T. Dougherty,et al.  Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse. , 1981, Cancer research.

[29]  James S. McCaughan,et al.  Palliation of esophageal malignancy with photoradiation therapy , 1984, Cancer.

[30]  E. Reddi,et al.  Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivo. , 1984, Cancer letters.

[31]  O J Balchum,et al.  Photoradiation therapy of endobronchial lung cancers employing the photodynamic action of hematoporphvrin derivative , 1984, Lasers in surgery and medicine.

[32]  B. Henderson,et al.  Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: comparison to ionizing radiation. , 1986, Radiation research.

[33]  M. Berns,et al.  Photoradiation therapy of gynecologic malignancies. , 1984, Gynecologic oncology.

[34]  T J Dougherty,et al.  Photoradiation in the treatment of recurrent breast carcinoma. , 1979, Journal of the National Cancer Institute.

[35]  T J Dougherty,et al.  CHARACTERIZATION OF INTRA‐TUMORAL PORPHYRIN FOLLOWING INJECTION OF HEMATOPORPHYRIN DERIVATIVE OR ITS PURIFIED COMPONENT * , 1987, Photochemistry and photobiology.

[36]  J. Moan.  PORPHYRIN PHOTOSENSITIZATION AND PHOTOTHERAPY , 1986, Photochemistry and photobiology.

[37]  J. Moan,et al.  Porphyrin-sensitized photoinactivation of cells in vitro. , 1984, Progress in clinical and biological research.

[38]  D. M. Burns,et al.  THE MEASUREMENT OF DIHEMATOPORPHYRIN ETHER CONCENTRATION IN TISSUE BY REFLECTANCE SPECTROPHOTOMETRY , 1987, Photochemistry and photobiology.

[39]  P. Smith,et al.  Photodynamic therapy of ascites tumours within the peritoneal cavity. , 1986, British Journal of Cancer.

[40]  R. Bryant,et al.  31P-NMR spectroscopy demonstrates decreased ATP levels in vivo as an early response to photodynamic therapy. , 1986, Biochemical and biophysical research communications.

[41]  L. O. Svaasand,et al.  Optical dosimetry for direct and interstitial photoradiation therapy of malignant tumors. , 1984, Progress in clinical and biological research.

[42]  C. Gomer,et al.  ACUTE SKIN RESPONSE IN ALBINO MICE FOLLOWING PORPHYRIN PHOTOSENSITIZATION UNDER OXIC AND ANOXIC CONDITIONS , 1984, Photochemistry and photobiology.

[43]  R. Bruce.  Evaluation of hematoporphyrin photoradiation therapy to treat choroidal melanomas , 1984, Lasers in surgery and medicine.

[44]  A E Profio,et al.  Digital background subtraction for fluorescence imaging. , 1986, Medical physics.

[45]  J Moan,et al.  PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY , 1987, Photochemistry and photobiology.

[46]  T. Dougherty.  Photosensitization of malignant tumors. , 1986, Seminars in surgical oncology.

[47]  S. Gibson,et al.  Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. , 1986, Cancer research.

[48]  S. Britton,et al.  Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. , 1984, Cancer research.

[49]  T J Dougherty,et al.  The structure of the active component of hematoporphyrin derivative. , 1984, Progress in clinical and biological research.

[50]  D. Kessel,et al.  Tumor-localizing components of the porphyrin preparation hematoporphyrin derivative. , 1983, Cancer research.

[51]  D. Kessel.  PROPOSED STRUCTURE OF THE TUMOR‐LOCALIZING FRACTION OF HPD (HEMATOPORPHYRIN DERIVATIVE) , 1986, Photochemistry and photobiology.

[52]  D. Kessel,et al.  Photosensitization with derivatives of haematoporphyrin. , 1986, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[53]  C. F. Welty.  CANCER OF THE EAR, NOSE AND THROAT. , 1920, California state journal of medicine.

[54]  H. Schellhas,et al.  Photodynamic therapy of gynecologic neoplasms after presensitization with hematoporphyrin derivative , 1985, Lasers in surgery and medicine.

[55]  E. Ben-hur,et al.  PHOTOSENSITIZATION OF CHINESE HAMSTER CELLS BY WATER‐SOLUBLE PHTHALOCYANINES * , 1986, Photochemistry and photobiology.

[56]  J E Kaufman,et al.  Photoradiation therapy for the treatment of malignant tumors. , 1978, Cancer research.

[57]  D. Kessel,et al.  Porphyrin-lipoprotein association as a factor in porphyrin localization. , 1986, Cancer letters.

[58]  W. Star,et al.  Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers. , 1986, Cancer research.

[59]  M S Patterson,et al.  The physics of photodynamic therapy. , 1986, Physics in medicine and biology.

[60]  J. Brown,et al.  Cytotoxic effects of the hypoxic cell radiosensitizer Ro 7-0582 to tumor cells in vivo. , 1977, Radiation research.

[61]  O. Balchum,et al.  Fluorescence bronchoscopy for localization of carcinoma in situ. , 1983, Medical physics.

[62]  E. Ben-hur,et al.  Factors affecting the photokilling of cultured Chinese hamster cells by phthalocyanines. , 1985, Radiation research.

[63]  G. Howlett,et al.  THE MOLECULAR WEIGHT OF HAEMATOPORPHYRIN DERIVATIVE, ITS GEL COLUMN FRACTIONS and SOME OF ITS COMPONENTS IN AQUEOUS SOLUTION , 1985, Photochemistry and photobiology.

[64]  T. Mang,et al.  Dihematoporphyrin ether clearance in primate bladders. , 1986, The Journal of urology.

[65]  E. Land,et al.  Porphyrin localization and treatment of tumors , 1985, British Journal of Cancer.

[66]  T J Dougherty,et al.  Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. , 1976, Cancer research.

[67]  D. Schuller,et al.  Photodynamic therapy in head and neck cancer. , 1985, Archives of otolaryngology.

[68]  Optical dosimetry in photodynamic therapy , 1986, Lasers in surgery and medicine.