Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the IkappaB/NF-kappaB cascade by facilitating IkappaB kinase renaturation and blocking its further denaturation.

[1]  C. Tanford,et al.  The gross conformation of protein-sodium dodecyl sulfate complexes. , 1970, The Journal of biological chemistry.

[2]  C. Tanford,et al.  Gel chromatography of proteins in denaturing solvents. Comparison between sodium dodecyl sulfate and guanidine hydrochloride as denaturants. , 1970, The Journal of biological chemistry.

[3]  K. Weber,et al.  3 – Proteins and Sodium Dodecyl Sulfate: Molecular Weight Determination on Polyacrylamide Gels and Related Procedures , 1975 .

[4]  M. Morange,et al.  Protein denaturation during heat shock and related stress. Escherichia coli beta-galactosidase and Photinus pyralis luciferase inactivation in mouse cells. , 1989, The Journal of biological chemistry.

[5]  O. Bensaude,et al.  Heat-shock-induced denaturation of proteins. Characterization of the insolubilization of the interferon-induced p68 kinase. , 1991, The Journal of biological chemistry.

[6]  A S Slutsky,et al.  Induction of heat stress proteins is associated with decreased mortality in an animal model of acute lung injury. , 1993, The American review of respiratory disease.

[7]  A S Slutsky,et al.  Induction of the heat shock response reduces mortality rate and organ damage in a sepsis‐induced acute lung injury model , 1994, Critical care medicine.

[8]  A. Baldwin,et al.  THE NF-κB AND IκB PROTEINS: New Discoveries and Insights , 1996 .

[9]  F. Hartl.  Molecular chaperones in cellular protein folding , 1996, Nature.

[10]  M. Neurath,et al.  Local administration of antisense phosphorothiate olignucleotides to the p65 subunit of NF–κB abrogates established experimental colitis in mice , 1996, Nature Medicine.

[11]  C. Mueller-Dieckmann,et al.  Tyrosine Phosphorylation of IκB-α Activates NF-κB without Proteolytic Degradation of IκB-α , 1996, Cell.

[12]  D. Reis,et al.  Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation* , 1996, The Journal of Biological Chemistry.

[13]  P. Baeuerle,et al.  Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. , 1996, Arthritis and rheumatism.

[14]  Donald J. Reis,et al.  Suppression of Glial Nitric Oxide Synthase Induction by Heat Shock: Effects on Proteolytic Degradation of IκB-α☆ , 1997 .

[15]  M. Vigneron,et al.  Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II. , 1997, Nucleic acids research.

[16]  J. Frydman,et al.  Chaperones get in touch: the Hip-Hop connection. , 1997, Trends in biochemical sciences.

[17]  E. Craig,et al.  Protein Folding In Vivo: Unraveling Complex Pathways , 1997, Cell.

[18]  Arthur S Slutsky,et al.  Heat stress increases survival rates in lipopolysaccharide-stimulated rats. , 1997, Critical care medicine.

[19]  M. Karin,et al.  Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. , 1997, The New England journal of medicine.

[20]  M J May,et al.  NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.

[21]  A. Baldwin,et al.  NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  M. Jäättelä,et al.  Hsp70 exerts its anti‐apoptotic function downstream of caspase‐3‐like proteases , 1998, The EMBO journal.

[23]  A. Giaccia,et al.  Heat Shock Protein 72 Modulates Pathways of Stress-induced Apoptosis* , 1998, The Journal of Biological Chemistry.

[24]  P. Baeuerle,et al.  Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[25]  O. Bensaude,et al.  Heat shock of HeLa cells inactivates a nuclear protein phosphatase specific for dephosphorylation of the C-terminal domain of RNA polymerase II. , 1999, Nucleic acids research.

[26]  D. Gius,et al.  Heat Shock Inhibits Radiation-induced Activation of NF-κB via Inhibition of I-κB Kinase* , 1999, The Journal of Biological Chemistry.

[27]  I. Macara,et al.  Cooperativity between Oxidants and Tumor Necrosis Factor in the Activation of Nuclear Factor (NF)- κ B , 1999 .

[28]  H. Wong,et al.  Heat shock inhibits phosphorylation of I-κBα , 2000 .

[29]  S. Han,et al.  NF-κB Activation Is Related to the Resistance of Lung Cancer Cells to TNF-α-Induced Apoptosis , 2000 .

[30]  S. Han,et al.  Anti-Inflammatory Effect of Heat Shock Protein Induction Is Related to Stabilization of IκBα Through Preventing IκB Kinase Activation in Respiratory Epithelial Cells1 , 2000, The Journal of Immunology.

[31]  R. Morimoto,et al.  Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2 , 2001, Molecular and Cellular Biology.

[32]  V. Malhotra,et al.  Heat Shock Inhibits Activation of NF-κB in the Absence of Heat Shock Factor-1 , 2002 .

[33]  S. Han,et al.  The heat-shock-induced suppression of the IkappaB/NF-kappaB cascade is due to inactivation of upstream regulators of IkappaBalpha through insolubilization. , 2004, Experimental cell research.