Organ movement reduction in PET/CT using dual-gated list-mode acquisition.

PURPOSE Imaging of moving organs using the PET leads to blurred images due to long acquisition times. Simultaneous cardiac and respiratory gating of list-mode PET/CT is evaluated with the aim to improve image quality and assess the organ movement. METHODS We performed a N-13 ammonia PET/CT scan with a human volunteer, using the Siemens Biograph Sensation 16 scanner with list-mode acquisition. For ECG gating we used the scanner's integrated ECG device. Respiratory gating was done with the BioVet pneumatic sensor system. RESULTS The sorting of the list-mode data post acquisition produced the desired matrix of eight cardiac times eight respiratory images. Organ movement could be measured in the series of gated PET images. The quantitation of tracer uptake in the myocardium showed artifacts due to the CT-based attenuation correction. CONCLUSION Double gating is feasible in human PET/CT scans using a list-mode-based scan protocol. The image quality can be enhanced using double gated list-mode acquisition in PET/CT Attenuation correction protocols in PET using a single not gated fast CT introduces artifacts in moving organs.

[1]  Paul Kinahan,et al.  A combined PET/CT scanner for clinical oncology. , 2000, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  Gikas S. Mageras,et al.  Interfractional anatomic variation in patients treated with respiration‐gated radiotherapy , 2005, Journal of applied clinical medical physics.

[3]  R. Lecomte,et al.  Respiratory gating for 3-dimensional PET of the thorax: feasibility and initial results. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  Thomas Beyer,et al.  X-ray-based attenuation correction for positron emission tomography/computed tomography scanners. , 2003, Seminars in nuclear medicine.

[5]  Kelly H Zou,et al.  Electrocardiographically gated 16-section CT of the thorax: cardiac motion suppression. , 2004, Radiology.

[6]  Thomas Beyer,et al.  Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[7]  Yuji Nakamoto,et al.  PET-CT evaluation of 2-deoxy-2-[18F]fluoro-D-glucose myocardial uptake: effect of respiratory motion. , 2003, Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.

[8]  Yuji Nakamoto,et al.  Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  Kenneth E Rosenzweig,et al.  Reduction of respiratory motion artifacts in PET imaging of lung cancer by respiratory correlated dynamic PET: methodology and comparison with respiratory gated PET. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  C. Ling,et al.  Effect of respiratory gating on quantifying PET images of lung cancer. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  Cyrill Burger,et al.  Respiration-induced attenuation artifact at PET/CT: technical considerations. , 2003, Radiology.

[12]  A. Pevsner,et al.  The CT motion quantitation of lung lesions and its impact on PET-measured SUVs. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.