Friends Turn Foe—Astrocytes Contribute to Neuronal Damage in NeuroAIDS

[1]  E. Eugenin,et al.  HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function , 2020, International journal of molecular sciences.

[2]  Alain Le Coupanec,et al.  Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? , 2019, Viruses.

[3]  Y. Persidsky,et al.  Chronic Intrahippocampal Infusion of HIV-1 Neurotoxic Proteins: A Novel Mouse Model of HIV-1 Associated Inflammation and Neural Stem Cell Dysfunction , 2019, Journal of Neuroimmune Pharmacology.

[4]  A. Nath,et al.  Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium , 2018, Journal of NeuroVirology.

[5]  M. Barbe,et al.  Adult neurogenic deficits in HIV-1 Tg26 transgenic mice , 2018, Journal of Neuroinflammation.

[6]  S. Spector,et al.  Human Immunodeficiency Virus Type 1 gp120 and Tat Induce Mitochondrial Fragmentation and Incomplete Mitophagy in Human Neurons , 2018, Journal of Virology.

[7]  J. Dougherty,et al.  Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis , 2018, Brain : a journal of neurology.

[8]  M. Tremblay,et al.  Astrocytes sustain long‐term productive HIV‐1 infection without establishment of reactivable viral latency , 2018, Glia.

[9]  C. Mactutus,et al.  Dose-dependent neurocognitive deficits following postnatal day 10 HIV-1 viral protein exposure: Relationship to hippocampal anatomy parameters , 2018, International Journal of Developmental Neuroscience.

[10]  J. Lasalde-Dominicci,et al.  The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders , 2018, Scientific Reports.

[11]  M. Kaul,et al.  Transgenic mice expressing HIV-1 envelope protein gp120 in the brain as an animal model in neuroAIDS research , 2018, Journal of NeuroVirology.

[12]  Jeffrey C. Smith,et al.  Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity , 2018, Nature Communications.

[13]  D. Kolson,et al.  Degradation of heme oxygenase‐1 by the immunoproteasome in astrocytes: A potential interferon‐γ‐dependent mechanism contributing to HIV neuropathogenesis , 2017, Glia.

[14]  Soo‐Young Choi,et al.  Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes , 2017, Redox biology.

[15]  S. Chandran,et al.  Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism , 2017, Nature communications.

[16]  S. Izumo,et al.  Decrease of aquaporin‐4 and excitatory amino acid transporter‐2 indicate astrocyte dysfunction for pathogenesis of cortical degeneration in HIV‐associated neurocognitive disorders , 2017, Neuropathology : official journal of the Japanese Society of Neuropathology.

[17]  P. Seth,et al.  Novel insights into role of miR‐320a‐VDAC1 axis in astrocyte‐mediated neuronal damage in neuroAIDS , 2017, Glia.

[18]  P. Fisher,et al.  HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis , 2017, Journal of Neuroinflammation.

[19]  K. Khalili,et al.  HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity , 2017, Cell Death & Disease.

[20]  Yan Fan,et al.  HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity* , 2016, The Journal of Biological Chemistry.

[21]  Yan Fan,et al.  HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation* , 2016, The Journal of Biological Chemistry.

[22]  A. Nath,et al.  Astrocytes as an HIV Reservoir: Mechanism of HIV Infection. , 2016, Current HIV research.

[23]  E. Lo,et al.  Transfer of mitochondria from astrocytes to neurons after stroke , 2016, Nature.

[24]  Z. Klase,et al.  The inhibition of microRNAs by HIV-1 Tat suppresses beta catenin activity in astrocytes , 2016, Retrovirology.

[25]  Loren L Looger,et al.  Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice , 2016, The Journal of Neuroscience.

[26]  M. Bennett,et al.  HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS , 2016, Journal of Neuroinflammation.

[27]  C. Walker,et al.  Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis , 2016, Nature Medicine.

[28]  C. Walker,et al.  MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS) , 2016, Nature medicine.

[29]  Hui Zheng,et al.  Signaling pathways regulating neuron–glia interaction and their implications in Alzheimer's disease , 2016, Journal of neurochemistry.

[30]  N. Vaidya,et al.  HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway , 2016, Scientific Reports.

[31]  Frank W. Pfrieger,et al.  Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes , 2015, Neuron.

[32]  Soo‐Young Choi,et al.  HDAC6 mediates HIV‐1 tat‐induced proinflammatory responses by regulating MAPK‐NF‐kappaB/AP‐1 pathways in astrocytes , 2015, Glia.

[33]  E. Major,et al.  Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4 , 2015, AIDS.

[34]  D. McGavern,et al.  Viral diseases of the central nervous system. , 2015, Current opinion in virology.

[35]  D. Westaway,et al.  Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity* , 2015, The Journal of Biological Chemistry.

[36]  Maureen H Richards,et al.  Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS , 2015, Glia.

[37]  P. Seth,et al.  Astrocytes mediate HIV‐1 Tat‐induced neuronal damage via ligand‐gated ion channel P2X7R , 2015, Journal of neurochemistry.

[38]  Harpreet S Gill,et al.  HIV-associated neurocognitive disorders (HAND). , 2015, The Israel Medical Association journal : IMAJ.

[39]  M. Churchill,et al.  Is the central nervous system a reservoir of HIV-1? , 2014, Current opinion in HIV and AIDS.

[40]  M. Colasanti,et al.  The role of arachidonic acid in the regulation of nitric oxide synthase isoforms by HIV gp120 protein in astroglial cells. , 2014, Free radical biology & medicine.

[41]  C. Cheng‐Mayer,et al.  Emergence of CD4 Independence Envelopes and Astrocyte Infection in R5 Simian-Human Immunodeficiency Virus Model of Encephalitis , 2014, Journal of Virology.

[42]  A. Chauhan,et al.  Endocytosis-mediated HIV-1 entry and its significance in the elusive behavior of the virus in astrocytes. , 2014, Virology.

[43]  M. Fu,et al.  HIV-1 Nef Induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors , 2014, Scientific Reports.

[44]  M. Bennett,et al.  HIV increases the release of dickkopf‐1 protein from human astrocytes by a Cx43 hemichannel‐dependent mechanism , 2014, Journal of neurochemistry.

[45]  J. Waddington,et al.  Resolving pathobiological mechanisms relating to Huntington disease: Gait, balance, and involuntary movements in mice with targeted ablation of striatal D1 dopamine receptor cells , 2014, Neurobiology of Disease.

[46]  James M. Robertson Astrocytes and the evolution of the human brain. , 2014, Medical hypotheses.

[47]  Eric H Kim,et al.  Widespread heterogeneous neuronal loss across the cerebral cortex in Huntington's disease. , 2014, Journal of Huntington's disease.

[48]  Anil Kumar,et al.  Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways , 2013, Journal of Neuroinflammation.

[49]  Anil Kumar,et al.  HIV-1 Tat-Mediated Induction of CCL5 in Astrocytes Involves NF-κB, AP-1, C/EBPα and C/EBPγ Transcription Factors and JAK, PI3K/Akt and p38 MAPK Signaling Pathways , 2013, PloS one.

[50]  M. Churchill,et al.  Where does HIV hide? A focus on the central nervous system , 2013, Current opinion in HIV and AIDS.

[51]  Y. Chern,et al.  A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease. , 2013, Human molecular genetics.

[52]  S. Rabe-Hesketh,et al.  The spatial relationship between neurons and astrocytes in HIV-associated dementia , 2013, Journal of NeuroVirology.

[53]  E. Major,et al.  Human Immunodeficiency Virus Type 1 (HIV-1) Transactivator of Transcription through Its Intact Core and Cysteine-Rich Domains Inhibits Wnt/β-Catenin Signaling in Astrocytes: Relevance to HIV Neuropathogenesis , 2012, The Journal of Neuroscience.

[54]  Stephen J. Smith,et al.  Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors , 2012, Nature.

[55]  S. Buch,et al.  HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway. , 2011, Biochemical and biophysical research communications.

[56]  B. Barres,et al.  Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC , 2011, Proceedings of the National Academy of Sciences.

[57]  J. Clements,et al.  Human Immunodeficiency Virus Infection of Human Astrocytes Disrupts Blood–Brain Barrier Integrity by a Gap Junction-Dependent Mechanism , 2011, The Journal of Neuroscience.

[58]  E. Halpern,et al.  Brain creatine elevation and N‐acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of NeuroAIDS , 2011, Magnetic resonance in medicine.

[59]  Sarah A. Stern,et al.  Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation , 2011, Cell.

[60]  E. Daar Faculty Opinions recommendation of HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. , 2011 .

[61]  Michael J. Taylor,et al.  HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy , 2010, Neurology.

[62]  Hee-Sup Shin,et al.  Channel-Mediated Tonic GABA Release from Glia , 2010, Science.

[63]  M. Sofroniew Molecular dissection of reactive astrogliosis and glial scar formation , 2009, Trends in Neurosciences.

[64]  Stephen J. Smith,et al.  Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis , 2009, Cell.

[65]  Lynette M. Smith,et al.  CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV‐1 brain infection , 2009, Journal of neuroscience research.

[66]  M. Churchill,et al.  Extensive astrocyte infection is prominent in human immunodeficiency virus–associated dementia , 2009, Annals of neurology.

[67]  Honghong Yao,et al.  HIV-1 Tat Co-Operates with IFN-γ and TNF-α to Increase CXCL10 in Human Astrocytes , 2009, PloS one.

[68]  Stephen J. Smith,et al.  Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis , 2009 .

[69]  D. Gutmann,et al.  Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis1 , 2008, The Journal of Immunology.

[70]  A. Ghorpade,et al.  CD38/Cyclic ADP-Ribose Regulates Astrocyte Calcium Signaling: Implications for Neuroinflammation and HIV-1-Associated Dementia , 2008, Journal of Neuroimmune Pharmacology.

[71]  S. Jayadev,et al.  The Glial Response to CNS HIV Infection Includes p53 Activation and Increased Expression of p53 Target Genes , 2007, Journal of Neuroimmune Pharmacology.

[72]  Hynek Wichterle,et al.  Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons , 2007, Nature Neuroscience.

[73]  S. Kramer,et al.  HIV-1 Nef upregulates CCL2/MCP-1 expression in astrocytes in a myristoylation- and calmodulin-dependent manner , 2006, Journal of Cell Science.

[74]  T. Takano,et al.  Astrocyte-mediated control of cerebral blood flow , 2006, Nature Neuroscience.

[75]  J. Howard,et al.  Low TRBP Levels Support an Innate Human Immunodeficiency Virus Type 1 Resistance in Astrocytes by Enhancing the PKR Antiviral Response , 2005, Journal of Virology.

[76]  J. Hell,et al.  Thrombospondins Are Astrocyte-Secreted Proteins that Promote CNS Synaptogenesis , 2005, Cell.

[77]  S. Gobbo,et al.  Neuronal Synchrony Mediated by Astrocytic Glutamate through Activation of Extrasynaptic NMDA Receptors , 2005, Neuron.

[78]  Francisco González-Scarano,et al.  The neuropathogenesis of AIDS , 2005, Nature Reviews Immunology.

[79]  Leif Hertz,et al.  Astrocytic control of glutamatergic activity: astrocytes as stars of the show , 2004, Trends in Neurosciences.

[80]  Johnny J. He,et al.  Astrocyte activation and dysfunction and neuron death by HIV-1 Tat expression in astrocytes , 2004, Molecular and Cellular Neuroscience.

[81]  S. Paul,et al.  Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides , 2004, Nature Medicine.

[82]  Kimberley A Walsh,et al.  Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity , 2004, Journal of Neuroinflammation.

[83]  Vladimir Parpura,et al.  Ca2+‐dependent glutamate release involves two classes of endoplasmic reticulum Ca2+ stores in astrocytes , 2004 .

[84]  Ngan B. Doan,et al.  Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury , 2004, The Journal of Neuroscience.

[85]  Jerry Silver,et al.  Regeneration beyond the glial scar , 2004, Nature Reviews Neuroscience.

[86]  R. Roine,et al.  Hyperglycemia in Acute Stroke , 2004, Stroke.

[87]  Vladimir Parpura,et al.  C(a2+)-dependent glutamate release involves two classes of endoplasmic reticulum Ca(2+) stores in astrocytes. , 2004, Journal of neuroscience research.

[88]  M. Poo,et al.  Contribution of astrocytes to hippocampal long-term potentiation through release of d-serine , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[89]  D. Purcell,et al.  Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia. , 2003, Current HIV research.

[90]  J. Rothstein,et al.  Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. , 2003, Virology.

[91]  D. Butterfield,et al.  Intracellular Human Immunodeficiency Virus Tat Expression in Astrocytes Promotes Astrocyte Survival but Induces Potent Neurotoxicity at Distant Sites via Axonal Transport* , 2003, The Journal of Biological Chemistry.

[92]  T. Wyss-Coray,et al.  Adult mouse astrocytes degrade amyloid-β in vitro and in situ , 2003, Nature Medicine.

[93]  Eric A Newman,et al.  Glial Cell Inhibition of Neurons by Release of ATP , 2003, The Journal of Neuroscience.

[94]  S. Duan,et al.  P2X7 Receptor-Mediated Release of Excitatory Amino Acids from Astrocytes , 2003, The Journal of Neuroscience.

[95]  M. C. Angulo,et al.  Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation , 2003, Nature Neuroscience.

[96]  K. Pahan,et al.  Human Immunodeficiency Virus Type 1 (HIV-1) Tat Induces Nitric-oxide Synthase in Human Astroglia* , 2002, The Journal of Biological Chemistry.

[97]  Stuart A. Lipton,et al.  Pathways to neuronal injury and apoptosis in HIV-associated dementia , 2001, Nature.

[98]  R. Lempicki,et al.  HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[99]  Clive N Svendsen,et al.  Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice , 1999, Neuron.

[100]  W. Lyman,et al.  HIV infection of fetal human astrocytes: the potential role of a receptor-mediated endocytic pathway , 1999, Brain Research.

[101]  M. Churchill,et al.  Diminished Production of Human Immunodeficiency Virus Type 1 in Astrocytes Results from Inefficient Translation ofgag, env, and nef mRNAs despite Efficient Expression of Tat and Rev , 1999, Journal of Virology.

[102]  C. Jahr,et al.  Glial Contribution to Glutamate Uptake at Schaffer Collateral–Commissural Synapses in the Hippocampus , 1998, The Journal of Neuroscience.

[103]  J. Glass,et al.  Localization of HIV‐1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry , 1996, Annals of neurology.

[104]  L. Mucke,et al.  Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. , 1996, The Journal of clinical investigation.

[105]  S. Lipton,et al.  The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid , 1995, The European journal of neuroscience.

[106]  Fang Liu,et al.  Glutamate-mediated astrocyte–neuron signalling , 1994, Nature.

[107]  E. Major,et al.  HIV‐1 infection of subcortical astrocytes in the pediatric central nervous system , 1994, Neurology.

[108]  J. Rothstein,et al.  Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. , 1992, The New England journal of medicine.