Ofloxacin induced steven johnson syndrome- case report

Steven Johnson syndrome (SJS) or Toxic Epidermal Ne crolysis (TEN) is a life threatening immune complex mediated hypersensitivity reaction which mainly inv olves skin and mucous membrane. SJS is generally in duced by the drugs. The manifestations include blisters on s ki , facial swelling, and hyper pigmentation. Here, a 20 year old Indian male received 400mg of ofloxacin over 3 days period for bacterial infection and experienced a s evere skin reaction which was diagnosed as toxic epidermal nec rolysis. Fluoroquinolones have rarely been implicat ed in cases of toxic epidermal necrosis. There are few case rep orts of other fluoroquinolones that have been assoc iated with toxic epidermal necrolysis. We hope that this case report create awareness to the health care professi nal that ofloxacin will cause toxic epidermal necrolysis.