Magnetic resonance imaging of transverse acoustic strain waves

We describe a phase contrast based MRI technique with high sensitivity to cyclic displacement that is capable of quantitatively imaging acoustic strain waves in tissue‐like materials. A formalism for considering gradient waveforms as basis functions to measure arbitrary cyclic motion waveforms is introduced. Experiments with tissue‐like agarose gel phantoms show that it is possible to measure small cyclic displacements at a submicron level by an appropriate choice of the applied gradient basis function and to use this capability to observe the spatial and temporal pattern of displacements caused by acoustic strain waves. The propagation characteristics of strain waves are determined by the mechanical properties of the media. It is therefore possible to use this technique to noninvasively estimate material properties such as elastic modulus.

[1]  T E Conturo,et al.  Signal‐to‐noise in phase angle reconstruction: Dynamic range extension using phase reference offsets , 1990, Magnetic resonance in medicine.

[2]  M O'Donnell,et al.  NMR blood flow imaging using multiecho, phase contrast sequences. , 1985, Medical physics.

[3]  G. Glover,et al.  Encoding strategies for three‐direction phase‐contrast MR imaging of flow , 1991, Journal of magnetic resonance imaging : JMRI.

[4]  D B Plewes,et al.  Visualizing tissue compliance with MR imaging , 1995, Journal of magnetic resonance imaging : JMRI.

[5]  A. Manduca,et al.  Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. , 1995, Science.

[6]  W. Denk,et al.  Oscillatory flow in the cochlea visualized by a magnetic resonance imaging technique. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Y. Yamakoshi,et al.  Ultrasonic imaging of internal vibration of soft tissue under forced vibration , 1990, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[8]  H. Oestreicher Field and Impedance of an Oscillating Sphere in a Viscoelastic Medium with an Application to Biophysics , 1951 .

[9]  E. Madsen,et al.  Ultrasonic shear wave properties of soft tissues and tissuelike materials. , 1983, The Journal of the Acoustical Society of America.

[10]  K J Parker,et al.  Tissue response to mechanical vibrations for "sonoelasticity imaging". , 1990, Ultrasound in medicine & biology.

[11]  L. Frizzell,et al.  Shear properties of mammalian tissues at low megahertz frequencies. , 1976, The Journal of the Acoustical Society of America.

[12]  K. Parker,et al.  "Sonoelasticity" images derived from ultrasound signals in mechanically vibrated tissues. , 1990, Ultrasound in medicine & biology.

[13]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[14]  M. Bernstein,et al.  Comparison of phase‐difference and complex‐difference processing in phase‐contrast MR angiography , 1991, Journal of magnetic resonance imaging : JMRI.

[15]  P. Dijk Direct cardiac NMR imaging of heart wall and blood flow velocity. , 1984 .

[16]  F. S. Vinson,et al.  A pulsed Doppler ultrasonic system for making noninvasive measurements of the mechanical properties of soft tissue. , 1987, Journal of rehabilitation research and development.

[17]  J. D. de Certaines,et al.  MR imaging of viscoelastic properties , 1995, Journal of magnetic resonance imaging : JMRI.

[18]  P. Carson,et al.  Magnetic-resonance imaging techniques for detection of elasticity variation. , 1995, Medical physics.

[19]  F. Dunn,et al.  Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. , 1978, The Journal of the Acoustical Society of America.

[20]  M. O’Donnell,et al.  Internal displacement and strain imaging using ultrasonic speckle tracking , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[21]  P. R. Moran A flow velocity zeugmatographic interlace for NMR imaging in humans. , 1982, Magnetic resonance imaging.

[22]  M. O’Donnell,et al.  Theoretical analysis and verification of ultrasound displacement and strain imaging , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[23]  B. Robinson,et al.  Analysis of encoding efficiency in MR imaging of velocity magnitude and direction , 1992, Magnetic resonance in medicine.