The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein–protein interactions

[1]  S. Lonial,et al.  14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors , 2018, Leukemia.

[2]  David E. James,et al.  Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function , 2017, Nature Communications.

[3]  Xiaowen Zhang,et al.  Nuclear Gene 33/Mig6 regulates the DNA damage response through an ATM serine/threonine kinase–dependent mechanism , 2017, The Journal of Biological Chemistry.

[4]  A. Hirsch,et al.  Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3. , 2017, European journal of medicinal chemistry.

[5]  Q. Zhou New insights into stem cells. , 2017, Journal of molecular cell biology.

[6]  M. A. Moseley,et al.  Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration , 2017, Molecular and Cellular Biology.

[7]  N. Tan,et al.  Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expression , 2017, Oncogene.

[8]  L. Kenner,et al.  When the guardian sleeps: Reactivation of the p53 pathway in cancer. , 2017, Mutation research.

[9]  A. Antson,et al.  Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. , 2017, Structure.

[10]  Xiaoping Zhou,et al.  Negative auto-regulators trap p53 in their web. , 2017, Journal of molecular cell biology.

[11]  C. M. Eischen Role of Mdm2 and Mdmx in DNA repair , 2017, Journal of molecular cell biology.

[12]  Cathy H. Wu,et al.  Protein Bioinformatics Databases and Resources. , 2017, Methods in molecular biology.

[13]  Dihua Yu,et al.  14-3-3ζ loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. , 2017, American journal of cancer research.

[14]  Hong Yu Wang,et al.  A Tbc1d1Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice , 2017, Diabetologia.

[15]  Matthew P Torres,et al.  Proteome-wide Structural Analysis of PTM Hotspots Reveals Regulatory Elements Predicted to Impact Biological Function and Disease , 2016, Molecular & Cellular Proteomics.

[16]  D. James,et al.  14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function , 2016, Nature Communications.

[17]  Zdeněk Tošner,et al.  Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1)* , 2016, The Journal of Biological Chemistry.

[18]  Chang S. Chan,et al.  Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells , 2016, Genes & development.

[19]  M. Cascante,et al.  Oncogenic regulation of tumor metabolic reprogramming , 2016, Oncotarget.

[20]  Kang Wang,et al.  14-3-3ζ promotes hepatocellular carcinoma venous metastasis by modulating hypoxia-inducible factor-1α , 2016, Oncotarget.

[21]  V. Papadopoulos,et al.  The role of the 14-3-3 protein family in health, disease, and drug development. , 2016, Drug discovery today.

[22]  K. Ko,et al.  Identification of a redox-modulatory interaction between selenoprotein W and 14-3-3 protein. , 2016, Biochimica et biophysica acta.

[23]  S. Morrison,et al.  Cancer, Oxidative Stress, and Metastasis. , 2016, Cold Spring Harbor symposia on quantitative biology.

[24]  Wenping Zhou,et al.  14-3-3ζ up-regulates hypoxia-inducible factor-1α in hepatocellular carcinoma via activation of PI3K/Akt/NF-кB signal transduction pathway. , 2015, International journal of clinical and experimental pathology.

[25]  H. Piwnica-Worms,et al.  Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. , 2015, DNA repair.

[26]  B. Wang,et al.  Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins , 2015, Neurobiology of Disease.

[27]  Matthew P. Torres,et al.  Structural Analysis of PTM Hotspots (SAPH-ire) – A Quantitative Informatics Method Enabling the Discovery of Novel Regulatory Elements in Protein Families , 2015, Molecular & Cellular Proteomics.

[28]  H. Piwnica-Worms,et al.  14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection* , 2015, The Journal of Biological Chemistry.

[29]  Stephen R. Piccolo,et al.  Histone Deacetylase 6 (HDAC6) Promotes the Pro-survival Activity of 14-3-3ζ via Deacetylation of Lysines within the 14-3-3ζ Binding Pocket* , 2015, The Journal of Biological Chemistry.

[30]  Jun Yao,et al.  14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. , 2015, Cancer cell.

[31]  Bin Zhang,et al.  PhosphoSitePlus, 2014: mutations, PTMs and recalibrations , 2014, Nucleic Acids Res..

[32]  Yu-Ju Chen,et al.  dbSNO 2.0: a resource for exploring structural environment, functional and disease association and regulatory network of protein S-nitrosylation , 2014, Nucleic Acids Res..

[33]  Andrew D. Mathis,et al.  Metabolic-Stress-Induced Rearrangement of the 14-3-3ζ Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3ζ Interaction with Phosphorylated Atg9 , 2014, Molecular and Cellular Biology.

[34]  Hong Yu Wang,et al.  GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. , 2014, Cellular signalling.

[35]  E. Ropelle,et al.  Effects of Physical Exercise on the P38MAPK/REDD1/14-3-3 Pathways in the Myocardium of Diet-Induced Obesity Rats , 2014, Hormone and Metabolic Research.

[36]  V. Papadopoulos,et al.  Protein Modifications Regulate the Role of 14-3-3γ Adaptor Protein in cAMP-induced Steroidogenesis in MA-10 Leydig Cells* , 2014, The Journal of Biological Chemistry.

[37]  T. Shlomi,et al.  Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.

[38]  C. Ottmann,et al.  Discovery of 14‐3‐3 Protein–Protein Interaction Inhibitors that Sensitize Multidrug‐Resistant Cancer Cells to Doxorubicin and the Akt Inhibitor GSK690693 , 2014, ChemMedChem.

[39]  S. K. R. Guduru,et al.  Small molecule modulators of protein-protein interactions: selected case studies. , 2014, Chemical reviews.

[40]  M. Yoshimura,et al.  HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs , 2014, Scientific Reports.

[41]  B. Evans,et al.  SOD2 to SOD1 Switch in Breast Cancer* , 2014, The Journal of Biological Chemistry.

[42]  Dihua Yu,et al.  14-3-3ζ orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. , 2014, Cancer research.

[43]  Ludovic C. Gillet,et al.  Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system , 2013, Nature Methods.

[44]  G. Wahl,et al.  AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity , 2013, Molecular and Cellular Biology.

[45]  I. Kim,et al.  Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W. , 2013, Biochimica et biophysica acta.

[46]  O. Kohlbacher,et al.  Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. , 2013, Chemical communications.

[47]  C. Ottmann Small-molecule modulators of 14-3-3 protein-protein interactions. , 2013, Bioorganic & medicinal chemistry.

[48]  Y. Ishigaki,et al.  Chk1‐mediated phosphorylation of receptor‐associated late transducer at serine 250 increases its stability by stimulating its interaction with 14‐3‐3 , 2013, Genes to cells : devoted to molecular & cellular mechanisms.

[49]  E. Schleicher,et al.  Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation* , 2013, The Journal of Biological Chemistry.

[50]  F. Khuri,et al.  Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade , 2013, Molecular and Cellular Biology.

[51]  Pengyuan Yang,et al.  14-3-3ε Mediates the Cell Fate Decision-Making Pathways in Response of Hepatocellular Carcinoma to Bleomycin-Induced DNA Damage , 2013, PloS one.

[52]  C. Ottmann,et al.  Synergistic binding of the phosphorylated S233- and S259-binding sites of C-RAF to one 14-3-3ζ dimer. , 2012, Journal of molecular biology.

[53]  A. Antson,et al.  Monomeric 14-3-3ζ Has a Chaperone-Like Activity and Is Stabilized by Phosphorylated HspB6 , 2012, Biochemistry.

[54]  H. Fu,et al.  Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis. , 2012, Bioorganic & medicinal chemistry letters.

[55]  G. Wahl,et al.  Hypoxia Activates Tumor Suppressor p53 by Inducing ATR-Chk1 Kinase Cascade-mediated Phosphorylation and Consequent 14-3-3γ Inactivation of MDMX Protein* , 2012, The Journal of Biological Chemistry.

[56]  R. Ralhan,et al.  14-3-3 zeta as novel molecular target for cancer therapy , 2012, Expert opinion on therapeutic targets.

[57]  J. Gronych,et al.  Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. , 2012, Cancer research.

[58]  L. Rasmussen,et al.  14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. , 2012, DNA repair.

[59]  W. Zhang,et al.  Targeting 14-3-3zeta in cancer therapy , 2011, Cancer Gene Therapy.

[60]  Dihua Yu,et al.  Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit , 2011, Oncogene.

[61]  D. James,et al.  The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. , 2011, The Biochemical journal.

[62]  Fabrizio Manetti,et al.  Computational techniques are valuable tools for the discovery of protein-protein interaction inhibitors: the 14-3-3σ case. , 2011, Bioorganic & medicinal chemistry letters.

[63]  M. Tinti,et al.  The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin , 2011, Trends in Endocrinology & Metabolism.

[64]  Chris T. Harvey,et al.  HDAC4 Protein Regulates HIF1α Protein Lysine Acetylation and Cancer Cell Response to Hypoxia* , 2011, The Journal of Biological Chemistry.

[65]  F. Khuri,et al.  Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor , 2011, Proceedings of the National Academy of Sciences.

[66]  J. Thompson,et al.  A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. , 2011, Molecular cell.

[67]  T. Nishizaki,et al.  Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase‐3/‐9 via a mitochondrial pathway linked to SDK/14‐3‐3 protein/Bax/cytochrome c , 2011, Journal of cellular physiology.

[68]  A. Aitken Post-translational modification of 14-3-3 isoforms and regulation of cellular function. , 2011, Seminars in cell & developmental biology.

[69]  F. Khuri,et al.  14-3-3 proteins as potential therapeutic targets. , 2011, Seminars in cell & developmental biology.

[70]  M. Yaffe,et al.  14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. , 2011, Seminars in cell & developmental biology.

[71]  M. Imoto,et al.  Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration* , 2011, The Journal of Biological Chemistry.

[72]  B. Katzenellenbogen,et al.  Reversal of endocrine resistance in breast cancer: interrelationships among 14-3-3ζ, FOXM1, and a gene signature associated with mitosis , 2011, Breast Cancer Research.

[73]  Hong Lin,et al.  14-3-3Zeta Positive Expression is Associated With a Poor Prognosis in Patients With Glioblastoma , 2011, Neurosurgery.

[74]  Nikolai N Sluchanko,et al.  Phosphomimicking mutations of human 14-3-3ζ affect its interaction with tau protein and small heat shock protein HspB6. , 2011, Archives of biochemistry and biophysics.

[75]  B. Viollet,et al.  Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.

[76]  J. Fredberg,et al.  A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening , 2011, Respiratory research.

[77]  Adrian V. Lee,et al.  High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti–IGF-IR Therapy , 2010, Clinical Cancer Research.

[78]  Dihua Yu,et al.  14-3-3ζ as a prognostic marker and therapeutic target for cancer , 2010, Expert opinion on therapeutic targets.

[79]  Fabrizio Manetti,et al.  Identification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis. , 2010, Bioorganic & medicinal chemistry letters.

[80]  Zhijian J. Chen,et al.  ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. , 2010, Molecular cell.

[81]  Angel F. Lopez,et al.  Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. , 2010, Cellular signalling.

[82]  M. Inagaki,et al.  14‐3‐3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage , 2010, The EMBO journal.

[83]  Pengyuan Yang,et al.  14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. , 2010, Journal of proteome research.

[84]  F. Costes,et al.  Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia. , 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

[85]  N. Grishin,et al.  Structural analysis and functional implications of the negative mTORC1 regulator REDD1. , 2010, Biochemistry.

[86]  F. Khuri,et al.  Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome , 2010, Oncogene.

[87]  D. Campbell,et al.  Bioinformatic and experimental survey of 14-3-3-binding sites , 2010, The Biochemical journal.

[88]  Zoltan Szallasi,et al.  Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer , 2010, Nature Medicine.

[89]  Z. Fei,et al.  Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice , 2010, Apoptosis.

[90]  H. Ichijo,et al.  Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation* , 2009, The Journal of Biological Chemistry.

[91]  Lixin Wei,et al.  Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells , 2009, Autophagy.

[92]  M. Hung,et al.  14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. , 2009, Cancer cell.

[93]  D. Hardie,et al.  Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. , 2009, American journal of physiology. Endocrinology and metabolism.

[94]  M. Mann,et al.  Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions , 2009, Science.

[95]  C. Plass,et al.  Copy number gain and oncogenic activity of YWHAZ/14‐3‐3ζ in head and neck squamous cell carcinoma , 2009, International journal of cancer.

[96]  C. MacKintosh,et al.  Differential 14-3-3 Affinity Capture Reveals New Downstream Targets of Phosphatidylinositol 3-Kinase Signaling* , 2009, Molecular & Cellular Proteomics.

[97]  G. Wahl,et al.  Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. , 2009, Cancer cell.

[98]  L. Nutt,et al.  Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. , 2009, Developmental cell.

[99]  H. Fu,et al.  14-3-3ζ Mediates Resistance of Diffuse Large B Cell Lymphoma to an Anthracycline-based Chemotherapeutic Regimen , 2009, The Journal of Biological Chemistry.

[100]  Anthony J. Muslin,et al.  Serine 58 of 14-3-3ζ Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death , 2009, Molecular and Cellular Biology.

[101]  Hua Guo,et al.  14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. , 2009, Cancer research.

[102]  M. Korc,et al.  14-3-3σ Modulates Pancreatic Cancer Cell Survival and Invasiveness , 2008, Clinical Cancer Research.

[103]  K. Sakamoto,et al.  Regulating the motor for GLUT4 vesicle traffic. , 2008, Cell metabolism.

[104]  D. James,et al.  CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes. , 2008, Cell metabolism.

[105]  A. Fersht,et al.  14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers , 2008, Nucleic acids research.

[106]  N. Gusev,et al.  Effect of mutations mimicking phosphorylation on the structure and properties of human 14-3-3zeta. , 2008, Archives of biochemistry and biophysics.

[107]  G. Lienhard,et al.  Non-functional phosphorylations? , 2008, Trends in biochemical sciences.

[108]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[109]  G. Semenza,et al.  Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia* , 2008, Journal of Biological Chemistry.

[110]  S. Lonial,et al.  Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070 , 2008, Leukemia.

[111]  D. Sgroi,et al.  Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. , 2008, Genes & development.

[112]  F. Khuri,et al.  Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation , 2008, Proceedings of the National Academy of Sciences.

[113]  E. Skoulakis,et al.  In Vivo Functional Specificity and Homeostasis of Drosophila 14-3-3 Proteins , 2007, Genetics.

[114]  Hong-Bin Fang,et al.  Up-regulation of 14-3-3zeta in lung cancer and its implication as prognostic and therapeutic target. , 2007, Cancer research.

[115]  R. Layfield,et al.  Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs. , 2007, International journal of oncology.

[116]  N. Grishin,et al.  SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. , 2007, Biochemistry.

[117]  J. Liou,et al.  Nonsteroidal Anti-inflammatory Drugs Induce Colorectal Cancer Cell Apoptosis by Suppressing 14-3-3ε , 2007 .

[118]  C. Ottmann,et al.  Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy. , 2007, Molecular cell.

[119]  C. Ottmann,et al.  Phosphorylation‐independent interaction between 14‐3‐3 and exoenzyme S: from structure to pathogenesis , 2007, The EMBO journal.

[120]  J. Liou,et al.  Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon. , 2007, Cancer research.

[121]  W. Hahn,et al.  Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. , 2006, Cell.

[122]  Y. Shiloh,et al.  Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage , 2006, Molecular and Cellular Biology.

[123]  Judit Villén,et al.  A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span , 2006, Cell.

[124]  M. Yaffe,et al.  Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. , 2006, Seminars in cancer biology.

[125]  C. Walker,et al.  Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning , 2006, The Journal of cell biology.

[126]  F. Khuri,et al.  Monitoring 14-3-3 Protein Interactions with a Homogeneous Fluorescence Polarization Assay , 2006, Journal of biomolecular screening.

[127]  T. Haystead,et al.  A role for PP1 in the Cdc2/Cyclin B-mediated positive feedback activation of Cdc25. , 2006, Molecular biology of the cell.

[128]  M. Dai,et al.  14‐3‐3γ binds to MDMX that is phosphorylated by UV‐activated Chk1, resulting in p53 activation , 2006, The EMBO journal.

[129]  N. L. La Thangue,et al.  14‐3‐3 proteins integrate E2F activity with the DNA damage response , 2006, The EMBO journal.

[130]  Jiandong Chen,et al.  Regulation of MDMX nuclear import and degradation by Chk2 and 14‐3‐3 , 2006, The EMBO journal.

[131]  M. Crescenzi,et al.  The Giardia duodenalis 14-3-3 Protein Is Post-translationally Modified by Phosphorylation and Polyglycylation of the C-terminal Tail* , 2006, Journal of Biological Chemistry.

[132]  G. Wildey,et al.  Evidence That Ser87 of BimEL Is Phosphorylated by Akt and Regulates BimEL Apoptotic Function* , 2006, Journal of Biological Chemistry.

[133]  J. Inoue,et al.  Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death* , 2005, Journal of Biological Chemistry.

[134]  Y. Shiloh,et al.  DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation , 2005, Molecular and Cellular Biology.

[135]  L. Nutt,et al.  Metabolic Regulation of Oocyte Cell Death through the CaMKII-Mediated Phosphorylation of Caspase-2 , 2005, Cell.

[136]  Fuminori Tsuruta,et al.  JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3 , 2005, The Journal of cell biology.

[137]  S. Pitson,et al.  Sphingosine Activates Protein Kinase A Type II by a Novel cAMP-independent Mechanism* , 2005, Journal of Biological Chemistry.

[138]  M. Yaffe,et al.  A Structural Basis for 14-3-3σ Functional Specificity*♦ , 2005, Journal of Biological Chemistry.

[139]  Robert J Ferl,et al.  Isoform-specific subcellular localization among 14-3-3 proteins in Arabidopsis seems to be driven by client interactions. , 2005, Molecular biology of the cell.

[140]  Jesse D. Martinez,et al.  Isoform‐specific expression of 14‐3‐3 proteins in human lung cancer tissues , 2005, International journal of cancer.

[141]  Michael B Yaffe,et al.  MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. , 2005, Molecular cell.

[142]  Kang Z. Liu,et al.  A Role for 14-3-3τ in E2F1 Stabilization and DNA Damage-induced Apoptosis* , 2004, Journal of Biological Chemistry.

[143]  L. Goodglick,et al.  Reduction of 9-nitrocamptothecin-triggered apoptosis in DU-145 human prostate cancer cells by ectopic expression of 14-3-3zeta. , 2004, International journal of oncology.

[144]  Fuminori Tsuruta,et al.  JNK promotes Bax translocation to mitochondria through phosphorylation of 14‐3‐3 proteins , 2004, The EMBO journal.

[145]  Yusuke Nakamura,et al.  Genome-wide cDNA microarray analysis of gene expression profiles in pancreatic cancers using populations of tumor cells and normal ductal epithelial cells selected for purity by laser microdissection , 2004, Oncogene.

[146]  H. Spaink,et al.  Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3σ and 14-3-3ζ , 2004, Journal of Cell Science.

[147]  M. Yaffe,et al.  14-3-3 Family Members Act Coordinately to Regulate Mitotic Progression , 2004, Cell cycle.

[148]  H. Fu,et al.  Activation of Apoptosis Signal-regulating Kinase 1 by Reactive Oxygen Species through Dephosphorylation at Serine 967 and 14-3-3 Dissociation* , 2004, Journal of Biological Chemistry.

[149]  Bradley P. Coe,et al.  Novel regions of amplification on 8q distinct from the MYC locus and frequently altered in oral dysplasia and cancer , 2004, Genes, chromosomes & cancer.

[150]  H. Spaink,et al.  Isoform-specific differences in rapid nucleocytoplasmic shuttling cause distinct subcellular distributions of 14-3-3 sigma and 14-3-3 zeta. , 2004, Journal of cell science.

[151]  S. R. Grant,et al.  CaM kinase IIδC phosphorylation of 14-3-3β in vascular smooth muscle cells: Activation of class II HDAC repression , 2004, Molecular and Cellular Biochemistry.

[152]  S. Shenolikar,et al.  PP1 control of M phase entry exerted through 14‐3‐3‐regulated Cdc25 dephosphorylation , 2003, The EMBO journal.

[153]  Mong-Hong Lee,et al.  14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth , 2003, Molecular and Cellular Biology.

[154]  Angel F. Lopez,et al.  The Dimeric Versus Monomeric Status of 14-3-3ζ Is Controlled by Phosphorylation of Ser58 at the Dimer Interface* , 2003, Journal of Biological Chemistry.

[155]  S. R. Datta,et al.  BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis , 2003, Nature.

[156]  Y. Sánchez,et al.  Regulation of Chk1 Includes Chromatin Association and 14-3-3 Binding following Phosphorylation on Ser-345* , 2003, Journal of Biological Chemistry.

[157]  Hui Zhao,et al.  Dual phosphorylation controls Cdc25 phosphatases and mitotic entry , 2003, Nature Cell Biology.

[158]  Rork Kuick,et al.  Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. , 2003, Cancer research.

[159]  S. R. Grant,et al.  CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression. , 2003, Molecular and cellular biochemistry.

[160]  Mong-Hong Lee,et al.  14-3-3 sigma positively regulates p53 and suppresses tumor growth. , 2003, Molecular and cellular biology.

[161]  S. Masters,et al.  Role of the 14‐3‐3 C‐terminal loop in ligand interaction , 2002, Proteins.

[162]  A. V. D. van den Ouweland,et al.  Identification and Characterization of the Interaction between Tuberin and 14-3-3ζ* , 2002, The Journal of Biological Chemistry.

[163]  Christian A. Rees,et al.  Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[164]  Kiyoshi Inoue,et al.  ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. , 2002, Genes & development.

[165]  Michael B. Yaffe,et al.  14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport , 2002, The Journal of cell biology.

[166]  Michael B Yaffe,et al.  How do 14‐3‐3 proteins work? – Gatekeeper phosphorylation and the molecular anvil hypothesis , 2002, FEBS letters.

[167]  A Aitken,et al.  Specificity of 14-3-3 isoform dimer interactions and phosphorylation. , 2001, Biochemical Society transactions.

[168]  S. Masters,et al.  14-3-3 Proteins Mediate an Essential Anti-apoptotic Signal* , 2001, The Journal of Biological Chemistry.

[169]  T Takahashi,et al.  ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis , 2001, EMBO reports.

[170]  Hiromu Suzuki,et al.  Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma , 2000, Oncogene.

[171]  J. Avruch,et al.  Calyculin A-induced Vimentin Phosphorylation Sequesters 14-3-3 and Displaces Other 14-3-3 Partners in Vivo * , 2000, The Journal of Biological Chemistry.

[172]  M. Morris,et al.  An Essential Phosphorylation-site Domain of Human cdc25C Interacts with Both 14-3-3 and Cyclins* , 2000, The Journal of Biological Chemistry.

[173]  M. Toyota,et al.  Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers. , 2000, Cancer research.

[174]  D. Schadendorf,et al.  Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two‐dimensional electrophoresis , 2000, Electrophoresis.

[175]  P. Cohen,et al.  Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155. , 2000, The Biochemical journal.

[176]  S R Datta,et al.  14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. , 2000, Molecular cell.

[177]  T. Pandita,et al.  High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[178]  T. N. Bhat,et al.  The Protein Data Bank , 2000, Nucleic Acids Res..

[179]  J. M. Bradshaw,et al.  Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase. , 1999, Journal of molecular biology.

[180]  H. Piwnica-Worms,et al.  DNA Damage and Replication Checkpoints in Fission Yeast Require Nuclear Exclusion of the Cdc25 Phosphatase via 14-3-3 Binding , 1999, Molecular and Cellular Biology.

[181]  E Ruoslahti,et al.  Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. , 1999, Biochemistry.

[182]  J. Kijne,et al.  Differences in spatial expression between 14-3-3 isoforms in germinating barley embryos. , 1999, Plant physiology.

[183]  H. Fu,et al.  Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[184]  J. Decaprio,et al.  Cytoplasmic Localization of Human cdc25C during Interphase Requires an Intact 14-3-3 Binding Site , 1999, Molecular and Cellular Biology.

[185]  A. Kumagai,et al.  Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. , 1999, Genes & development.

[186]  H. Piwnica-Worms,et al.  A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[187]  C. Chothia,et al.  The atomic structure of protein-protein recognition sites. , 1999, Journal of molecular biology.

[188]  P. Russell,et al.  Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein , 1999, Nature.

[189]  J Pohl,et al.  14-3-3ζ Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove* , 1998, The Journal of Biological Chemistry.

[190]  E. Stavridi,et al.  ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins , 1998, Nature Genetics.

[191]  Kohei Miyazono,et al.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.

[192]  C. Peng,et al.  C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[193]  S. Howell,et al.  14-3-3 Is Phosphorylated by Casein Kinase I on Residue 233 , 1997, The Journal of Biological Chemistry.

[194]  C. Peng,et al.  Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. , 1997, Science.

[195]  N. Rhind,et al.  Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. , 1997, Science.

[196]  D. Shaw,et al.  Isolation of a Dictyostelium discoideum 14-3-3 homologue. , 1997, Biochimica et biophysica acta.

[197]  R. Liddington,et al.  Raf-1 Kinase and Exoenzyme S Interact with 14-3-3ζ through a Common Site Involving Lysine 49* , 1997, The Journal of Biological Chemistry.

[198]  N. Rhind,et al.  Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. , 1997, Genes & development.

[199]  Minoru Takagi,et al.  Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways , 1997, Science.

[200]  Elizabeth Yang,et al.  Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL , 1996, Cell.

[201]  D. Beach,et al.  14-3-3 proteins associate with cdc25 phosphatases. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[202]  S. Howell,et al.  14-3-3 alpha and delta are the phosphorylated forms of raf-activating 14-3-3 beta and zeta. In vivo stoichiometric phosphorylation in brain at a Ser-Pro-Glu-Lys MOTIF. , 1995, The Journal of biological chemistry.

[203]  E. Krebs,et al.  Phosphorylation-dephosphorylation of enzymes. , 1979, Annual review of biochemistry.