Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents.

[1]  A. Suksamrarn,et al.  Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol. , 2013, European journal of medicinal chemistry.

[2]  R. Cao,et al.  Synthesis and structure-activity relationships of harmine derivatives as potential antitumor agents. , 2013, European journal of medicinal chemistry.

[3]  K. Petrov,et al.  Unfolded and macrocyclic ammonium derivatives of diterpenoids steviol and isosteviol having choline moieties. Synthesis and inhibitory activities toward acetylcholine- and butyrylcholinesterases , 2012 .

[4]  M. Gouda,et al.  Synthesis, antitumor, cytotoxic and antioxidant evaluation of some new pyrazolotriazines attached to antipyrine moiety. , 2012, European journal of medicinal chemistry.

[5]  Tao Zhang,et al.  D-ring modified novel isosteviol derivatives: design, synthesis and cytotoxic activity evaluation. , 2012, Bioorganic & medicinal chemistry letters.

[6]  P. Lei,et al.  Synthesis and antitumor activity of 5,6-dihydro-17-hydroxy icogenin analogs. , 2012, European journal of medicinal chemistry.

[7]  W. Hua,et al.  Synthesis and evaluation of cytotoxic effects of novel α-methylenelactone tetracyclic diterpenoids. , 2012, Bioorganic & medicinal chemistry letters.

[8]  A. D. Voloshina,et al.  Synthesis and antimicrobial activity of several bis-quaternized ammonium derivatives of the diterpenoid isosteviol , 2012, Chemistry of Natural Compounds.

[9]  K. S. Rao,et al.  Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. , 2011, Bioorganic & medicinal chemistry letters.

[10]  T. Vilaivan,et al.  Synthesis of rotenoid derivatives with cytotoxic and topoisomerase II inhibitory activities. , 2011, Bioorganic & medicinal chemistry letters.

[11]  Dayong Zhang,et al.  Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents. , 2011, Bioorganic & medicinal chemistry letters.

[12]  D. Biedermann,et al.  Synthesis and Evaluation ofBiological Activity of the Quaternary Ammonium Salts of Lupane-,Oleanane-, and Ursane-Type Acids , 2010 .

[13]  Dae-Kee Kim,et al.  Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. , 2010, Bioorganic & medicinal chemistry letters.

[14]  G. Dai,et al.  Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities. , 2009, Bioorganic & medicinal chemistry letters.

[15]  I. Zupkó,et al.  Efficient approach to androstene-fused arylpyrazolines as potent antiproliferative agents. Experimental and theoretical studies of substituent effects on BF(3)-catalyzed intramolecular [3 + 2] cycloadditions of olefinic phenylhydrazones. , 2009, Journal of the American Chemical Society.

[16]  T. Yamori,et al.  Synthesis of hybrid acetogenins, alpha,beta-unsaturated-gamma-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines. , 2008, Bioorganic & medicinal chemistry letters.

[17]  J. Liaw,et al.  Microbial transformation of isosteviol and bioactivities against the glucocorticoid/androgen response elements. , 2008, Journal of natural products.

[18]  I. Chaaban,et al.  Design, synthesis, and in vitro evaluation of cytotoxic activity of new substituted 1,4-benzoquinones and hydroquinones , 2007, Medicinal Chemistry Research.

[19]  D. J. Foster,et al.  THE EFFECTS OF ISOSTEVIOL AGAINST MYOCARDIUM INJURY INDUCED BY ISCHAEMIA–REPERFUSION IN THE ISOLATED GUINEA PIG HEART , 2007, Clinical and experimental pharmacology & physiology.

[20]  O. Fedorova,et al.  Synthesis and anti-tuberculous activity of diesters based on isosteviol and dicarboxylic acids , 2006, Pharmaceutical Chemistry Journal.

[21]  A. Renslo,et al.  Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. , 2006, Bioorganic & Medicinal Chemistry Letters.

[22]  Meng Chen,et al.  Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes. , 2006, Bioorganic & medicinal chemistry letters.

[23]  Jaung-Geng Lin,et al.  Antiproliferative Effect of Isosteviol on Angiotensin-II-Treated Rat Aortic Smooth Muscle Cells , 2006, Pharmacology.

[24]  A. Amr,et al.  Synthesis and antiandrogenic activity of some new 3-substituted androstano[17,16-c]-5'-aryl-pyrazoline and their derivatives. , 2006, Bioorganic & medicinal chemistry.

[25]  Yan-Bing Zhang,et al.  Synthesis and Bioactivity of Isosteviol Derivatives: A Facile Method for Preparation of Ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic Acid , 2005 .

[26]  Nadia R. Mohamed,et al.  Synthesis of biologically active steroid derivatives by the utility of Lawesson's reagent , 2005, Steroids.

[27]  Sung Soo Kim,et al.  Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents. , 2004, Bioorganic & medicinal chemistry letters.

[28]  F. Hsu,et al.  Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. , 2004, Life sciences.

[29]  S. Chandrasekhar,et al.  Natural product hybrids as new leads for drug discovery. , 2003, Angewandte Chemie.

[30]  E. G. Carnieri,et al.  Activity of isosteviol lactone on mitochondrial metabolism. , 2003, Toxicology letters.

[31]  S. Kitanaka,et al.  Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. , 2002, Biological & pharmaceutical bulletin.

[32]  T. Schneider,et al.  Stereoselective synthesis of some novel heterocyclic estrone derivatives by intramolecular 1,3-dipolar cycloaddition , 2002 .

[33]  P. Chan,et al.  THE ANTIHYPERTENSIVE EFFECTS OF STEVIOSIDE DERIVATIVE ISOSTEVIOL IN SPONTANEOUSLY HYPERTENSIVE RATS , 2001 .

[34]  A. Bacchi,et al.  Synthesis and antimicrobial activity of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles. , 2000, Bioorganic & medicinal chemistry.

[35]  F. Chang,et al.  Bioactive kaurane diterpenoids from Annona glabra. , 1998, Journal of natural products.

[36]  J. Castellano,et al.  Bis-naphthalimides. 2. Synthesis and biological activity of 5,6-acenaphthalimidoalkyl-1,8-naphthalimidoalkyl amines , 1995 .

[37]  M. Melis Renal excretion of stevioside in rats. , 1992, Journal of natural products.

[38]  A. Kinghorn,et al.  A phytochemical screening procedure for sweet ent-kaurene glycosides in the genus Stevia. , 1984, Journal of natural products.