An Important Discovery in Context

to a new platform, the ability to detectthe revised profile from formalin-fixed paraffin-embeddedtissues as well as from fine-needle aspiration biopsies ofintraocular tumors in patients, and preliminary outcomesdata. What has emerged is a clinically useful and accuratemolecular prognostic classification for uveal melanocyticneoplasms. This significant advance appears nearly 80years after Callender’s discovery that the morphology ofuveal melanoma cells is associated with outcome.

[1]  J. Harbour,et al.  An accurate, clinically feasible multi-gene expression assay for predicting metastasis in uveal melanoma. , 2010, The Journal of molecular diagnostics : JMD.

[2]  R. Folberg,et al.  Using the direct-injection model of early uveal melanoma hepatic metastasis to identify TPS as a potentially useful serum biomarker. , 2007, Investigative ophthalmology & visual science.

[3]  R. Tubbs,et al.  Variation of monosomy 3 status within uveal melanoma. , 2007, Archives of pathology & laboratory medicine.

[4]  Justis P. Ehlers,et al.  Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death , 2004, Cancer Research.

[5]  Jennifer I. Lim,et al.  The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma II: initial mortality findings. COMS report no. 10. , 1998, American journal of ophthalmology.

[6]  R. Folberg Tumor progression in ocular melanomas. , 1993, The Journal of investigative dermatology.

[7]  J. Rootman,et al.  Monosomy 3 and isochromosome 8q in a uveal melanoma. , 1990, Cancer genetics and cytogenetics.

[8]  R. Greenberg,et al.  Interval‐by‐interval cox model analysis of 3680 cases of intraocular melanoma shows a decline in the prognostic value of size and cell type over time after tumor excision , 1988, Cancer.

[9]  J. Gamel,et al.  Modifications of Callender's classification of uveal melanoma at the Armed Forces Institute of Pathology. , 1983, American journal of ophthalmology.

[10]  J. Gass,et al.  Problems in the differential diagnosis of choroidal nevi and malignant melanomas. The XXXIII Edward Jackson Memorial Lecture. , 1977, American journal of ophthalmology.

[11]  B. Damato,et al.  Genomic typing of uveal melanoma. , 2009, Archives of ophthalmology.

[12]  E. Jordanova,et al.  The heterogeneous distribution of monosomy 3 in uveal melanomas: implications for prognostication based on fine-needle aspiration biopsies. , 2007, Archives of pathology & laboratory medicine.

[13]  I. McLean The biology of haematogenous metastasis in human meal malignant melanoma , 2005, Virchows Archiv A.

[14]  R. Folberg,et al.  Fine needle aspiration biopsy in the diagnosis of intraocular cancer. Cytologic-histologic correlations. , 1985, Ophthalmology.