Epigenetic obstacles encountered by transcription factors: reprogramming against all odds.

[1]  S. Yamanaka.  Induced pluripotent stem cells: past, present, and future. , 2012, Cell stem cell.

[2]  Christoph Bock,et al.  Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk , 2012, Genome research.

[3]  M. Robinson,et al.  Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA , 2012, Genome research.

[4]  B. Williams,et al.  Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity , 2012, Cell.

[5]  Eric S. Lander,et al.  Chromatin modifying enzymes as modulators of reprogramming , 2012, Nature.

[6]  Marius Wernig,et al.  Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells , 2012, Proceedings of the National Academy of Sciences.

[7]  G. Daley,et al.  The promise of induced pluripotent stem cells in research and therapy , 2012, Nature.

[8]  D. Schroeder,et al.  Role of DNMT3B in the regulation of early neural and neural crest specifiers , 2012, Epigenetics.

[9]  D. Surmeier,et al.  Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD , 2011, Nature.

[10]  Vijay K. Tiwari,et al.  DNA-binding factors shape the mouse methylome at distal regulatory regions , 2011, Nature.

[11]  Gangning Liang,et al.  Polycomb-Repressed Genes Have Permissive Enhancers that Initiate Reprogramming , 2011, Cell.

[12]  Rudolf Jaenisch,et al.  Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. , 2011, Cell stem cell.

[13]  F. Lienert,et al.  Identification of genetic elements that autonomously determine DNA methylation states , 2011, Nature Genetics.

[14]  J. Carroll,et al.  Pioneer transcription factors: establishing competence for gene expression. , 2011, Genes & development.

[15]  Kevin Eggan,et al.  Conversion of mouse and human fibroblasts into functional spinal motor neurons. , 2011, Cell stem cell.

[16]  Hiroyuki Hirai,et al.  Radical Acceleration of Nuclear Reprogramming by Chromatin Remodeling with the Transactivation Domain of MyoD , 2011, Stem cells.

[17]  Peter A. Jones,et al.  OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes , 2011, Proceedings of the National Academy of Sciences.

[18]  J. Rinn,et al.  lincRNAs act in the circuitry controlling pluripotency and differentiation , 2011, Nature.

[19]  L. Hui,et al.  Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors , 2011, Nature.

[20]  Jiaxuan Chen,et al.  Conversion of Sox17 into a Pluripotency Reprogramming Factor by Reengineering Its Association with Oct4 on DNA , 2011, Stem cells.

[21]  Jonathan M. Monk,et al.  Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network , 2011, Cell.

[22]  J. Eeckhoute,et al.  Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. , 2011, Genome research.

[23]  Gang Wang,et al.  Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy , 2011, Nature Cell Biology.

[24]  Hynek Wichterle,et al.  A functionally characterized test set of human induced pluripotent stem cells , 2011, Nature Biotechnology.

[25]  Michael J. Ziller,et al.  Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines , 2011, Cell.

[26]  Zachary D. Smith,et al.  Reprogramming factor expression initiates widespread targeted chromatin remodeling. , 2011, Cell stem cell.

[27]  J. Rinn,et al.  Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells , 2010, Nature Genetics.

[28]  S. Smale.  Pioneer factors in embryonic stem cells and differentiation. , 2010, Current opinion in genetics & development.

[29]  A. Meissner.  Epigenetic modifications in pluripotent and differentiated cells , 2010, Nature Biotechnology.

[30]  Jialiang Liang,et al.  A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. , 2010, Cell stem cell.

[31]  J. Wrana,et al.  Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. , 2010, Cell stem cell.

[32]  Marcos J. Araúzo-Bravo,et al.  Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming , 2010, Cell.

[33]  Christopher B. Burge,et al.  c-Myc Regulates Transcriptional Pause Release , 2010, Cell.

[34]  Jian Xu,et al.  Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells. , 2009, Genes & development.

[35]  T. Enver,et al.  Forcing cells to change lineages , 2009, Nature.

[36]  Shaorong Gao,et al.  Cell Stem Cell Brief Report Ips Cells Can Support Full-term Development of Tetraploid Blastocyst-complemented Embryos Cell Stem Cell Brief Report , 2022 .

[37]  Qi Zhou,et al.  iPS cells produce viable mice through tetraploid complementation , 2009, Nature.

[38]  R. M. Henke,et al.  Ascl1 and Neurog2 form novel complexes and regulate Delta-like3 (Dll3) expression in the neural tube. , 2009, Developmental biology.

[39]  Mike J. Mason,et al.  Role of the Murine Reprogramming Factors in the Induction of Pluripotency , 2009, Cell.

[40]  Shinya Yamanaka,et al.  Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors , 2008, Science.

[41]  Douglas A. Melton,et al.  In vivo reprogramming of adult pancreatic exocrine cells to β-cells , 2008, Nature.

[42]  Kelly J. Morris,et al.  Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2 , 2008, PLoS genetics.

[43]  T. Mikkelsen,et al.  Dissecting direct reprogramming through integrative genomic analysis , 2008, Nature.

[44]  Wenjun Guo,et al.  Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds , 2008, Nature Biotechnology.

[45]  T. Graf,et al.  PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells , 2008, Proceedings of the National Academy of Sciences.

[46]  Clifford A. Meyer,et al.  FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription , 2008, Cell.

[47]  Marius Wernig,et al.  c-Myc is dispensable for direct reprogramming of mouse fibroblasts. , 2008, Cell stem cell.

[48]  M. Hatta,et al.  Chromatin Opening and Stable Perturbation of Core Histone:DNA Contacts by FoxO1* , 2007, Journal of Biological Chemistry.

[49]  Paul Tempst,et al.  Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. , 2007, Molecular cell.

[50]  A. Philpott,et al.  Regulation of neurogenin stability by ubiquitin-mediated proteolysis. , 2007, The Biochemical journal.

[51]  Matthias Mann,et al.  Selective Anchoring of TFIID to Nucleosomes by Trimethylation of Histone H3 Lysine 4 , 2007, Cell.

[52]  Marius Wernig,et al.  Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells , 2007, Nature Biotechnology.

[53]  P. Santisteban,et al.  The Forkhead Factor FoxE1 Binds to the Thyroperoxidase Promoter during Thyroid Cell Differentiation and Modifies Compacted Chromatin Structure , 2007, Molecular and Cellular Biology.

[54]  J. Utikal,et al.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. , 2007, Cell stem cell.

[55]  M. Breslin,et al.  Neurogenin 3 recruits CBP co‐activator to facilitate histone H3/H4 acetylation in the target gene INSM1 , 2007, FEBS letters.

[56]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[57]  Giacomo Finocchiaro,et al.  Myc-binding-site recognition in the human genome is determined by chromatin context , 2006, Nature Cell Biology.

[58]  Lisha Xu,et al.  The Forkhead Transcription Factor FoxI1 Remains Bound to Condensed Mitotic Chromosomes and Stably Remodels Chromatin Structure , 2006, Molecular and Cellular Biology.

[59]  T. Graf,et al.  Stepwise Reprogramming of B Cells into Macrophages , 2004, Cell.

[60]  T. Matsuoka,et al.  Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells , 2003, Molecular and Cellular Biology.

[61]  Matthias Wilmanns,et al.  Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. , 2003, Genes & development.

[62]  H. Asahara,et al.  Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9* , 2003, Journal of Biological Chemistry.

[63]  R. Jaenisch,et al.  Monoclonal mice generated by nuclear transfer from mature B and T donor cells , 2002, Nature.

[64]  Frank R. Lin,et al.  Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. , 2002, Molecular cell.

[65]  S. Rhodes,et al.  Role of the LIM domains in DNA recognition by the Lhx3 neuroendocrine transcription factor. , 2001, Gene.

[66]  Ryozo Nagai,et al.  Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation , 2001, Nature Genetics.

[67]  Raymond J MacDonald,et al.  DNA Binding and Transcriptional Activation by a PDX1·PBX1b·MEIS2b Trimer and Cooperation with a Pancreas-specific Basic Helix-Loop-Helix Complex* , 2001, The Journal of Biological Chemistry.

[68]  P. Parsons,et al.  Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors. , 2000, European journal of biochemistry.

[69]  F. Cohen,et al.  Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. , 2000, Journal of molecular biology.

[70]  A. Rizzino,et al.  Identification of the Transactivation Domain of the Transcription Factor Sox-2 and an Associated Co-activator* , 2000, The Journal of Biological Chemistry.

[71]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[72]  D. Ambrosetti,et al.  Synergistic activation of the fibroblast growth factor 4 enhancer by Sox2 and Oct-3 depends on protein-protein interactions facilitated by a specific spatial arrangement of factor binding sites , 1997, Molecular and cellular biology.

[73]  M. Surani,et al.  Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells , 1997, The EMBO journal.

[74]  A. J. Walhout,et al.  c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene. , 1997, Nucleic acids research.

[75]  I. Wilmut,et al.  "Viable Offspring Derived from Fetal and Adult Mammalian Cells" (1997), by Ian Wilmut et al. , 2014 .

[76]  S. Tapscott,et al.  Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis. , 1997, Genes & development.

[77]  R. Schulz,et al.  Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. , 1995, Developmental biology.

[78]  S. Orkin,et al.  Self-association of the erythroid transcription factor GATA-1 mediated by its zinc finger domains , 1995, Molecular and cellular biology.

[79]  A. Bird,et al.  Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island. , 1994, Genes & development.

[80]  Z. Siegfried,et al.  Spl elements protect a CpG island from de novo methylation , 1994, Nature.

[81]  B. Paterson,et al.  Phosphorylation inhibits the DNA-binding activity of MyoD homodimers but not MyoD-E12 heterodimers. , 1993, The Journal of biological chemistry.

[82]  H. Weintraub,et al.  Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[83]  S. Burley,et al.  Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5 , 1993, Nature.

[84]  S. Orkin,et al.  DNA-binding specificity of GATA family transcription factors , 1993, Molecular and cellular biology.

[85]  J. D. Engel,et al.  DNA-binding specificities of the GATA transcription factor family , 1993, Molecular and cellular biology.

[86]  N. Heintz,et al.  Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. , 1991, Science.

[87]  P. Johnson,et al.  A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. , 1991, Genes & development.

[88]  N. Heintz,et al.  Differential phosphorylation of the transcription factor Oct1 during the cell cycle , 1991, Science.

[89]  S. Tapscott,et al.  Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[90]  H. Weintraub,et al.  Expression of a single transfected cDNA converts fibroblasts to myoblasts , 1987, Cell.

[91]  T. Elsdale,et al.  Sexually Mature Individuals of Xenopus laevis from the Transplantation of Single Somatic Nuclei , 1958, Nature.

[92]  関谷 明香,et al.  Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors , 2012 .

[93]  M. Surani,et al.  The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development , 2001 .