pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

[1]  David Bouchez,et al.  Manipulating the Mouse Embryo , 2007 .

[2]  M. Gannon,et al.  The FoxM1 Transcription Factor Is Required to Maintain Pancreatic β-Cell Mass , 2006 .

[3]  Ji-yeon Lee,et al.  RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function* , 2006, Journal of Biological Chemistry.

[4]  M. Gannon,et al.  The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass. , 2006, Molecular endocrinology.

[5]  R. Hammer,et al.  The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. , 2005, Developmental biology.

[6]  P. Gruss,et al.  Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes. , 2004, Developmental biology.

[7]  L. Sussel,et al.  Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Jan Jensen,et al.  Gene regulatory factors in pancreatic development , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[9]  D. Melton,et al.  Notch signaling controls multiple steps of pancreatic differentiation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[10]  G. Webb,et al.  Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis. , 2003, Endocrinology.

[11]  L. Sussel,et al.  Transcription Factor Occupancy of the Insulin Gene in Vivo , 2003, The Journal of Biological Chemistry.

[12]  M. German,et al.  Gene expression cascades in pancreatic development , 2003, Mechanisms of Development.

[13]  K. Prasadan,et al.  Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas. , 2002, Diabetes.

[14]  Hideaki Kagami,et al.  Experimental control of pancreatic development and maintenance , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  C. Wright,et al.  The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors , 2002, Nature Genetics.

[16]  M. German,et al.  Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas , 2002, Mechanisms of Development.

[17]  D. Melton,et al.  Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. , 2002, Development.

[18]  J. C. James,et al.  Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. , 2002, The Journal of biological chemistry.

[19]  D. Hill,et al.  Increased Islet Cell Proliferation, Decreased Apoptosis, and Greater Vascularization Leading to β-Cell Hyperplasia in Mutant Mice Lacking Insulin. , 2002, Endocrinology.

[20]  D. Piston,et al.  Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion* , 2002, The Journal of Biological Chemistry.

[21]  D. Hill,et al.  Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. , 2002, Endocrinology.

[22]  C. Wright,et al.  Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. , 2001, Developmental biology.

[23]  K. Kaestner,et al.  Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. , 2001, Genes & development.

[24]  H. Edlund,et al.  Attenuation of FGF signalling in mouse β-cells leads to diabetes , 2000, Nature.

[25]  C. Wright,et al.  Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. , 2000, Development.

[26]  P. Herrera,et al.  Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. , 2000, Development.

[27]  P. Gruss,et al.  Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas , 2000, Mechanisms of Development.

[28]  C. Wright,et al.  Mosaic Cre‐mediated recombination in pancreas using the pdx‐1 enhancer/promoter , 2000, Genesis.

[29]  M. Magnuson,et al.  Analysis of the Cre‐mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas , 2000, Genesis.

[30]  Allen,et al.  Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes , 1999, The Journal of clinical investigation.

[31]  H. Edlund,et al.  Attenuation of FGF signalling in mouse beta-cells leads to diabetes. , 2000, Nature.

[32]  M. Washington,et al.  Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. , 1999, Gastroenterology.

[33]  J. Nielsen,et al.  Developmental expression of proprotein convertase 1/3 in the rat , 1999, Molecular and Cellular Endocrinology.

[34]  E. Li.  The mojo of methylation , 1999, Nature Genetics.

[35]  S. Arber,et al.  Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9 , 1999, Nature Genetics.

[36]  David J. Anderson,et al.  Notch signalling controls pancreatic cell differentiation , 1999, Nature.

[37]  S. Bonner-Weir,et al.  The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. , 1999, Diabetes.

[38]  M. Magnuson,et al.  Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.

[39]  Philippe Soriano.  Generalized lacZ expression with the ROSA26 Cre reporter strain , 1999, Nature Genetics.

[40]  Sally A. Moody,et al.  Cell lineage and fate determination , 1999 .

[41]  C. Wright,et al.  Endodermal Patterning and Organogenesis , 1999 .

[42]  A. Krapp,et al.  The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. , 1998, Genes & development.

[43]  J. Habener,et al.  Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. , 1998, The Journal of clinical investigation.

[44]  H. Edlund,et al.  beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. , 1998, Genes & development.

[45]  S. Bonner-Weir,et al.  Regulatory factor linked to late-onset diabetes? , 1998, Nature.

[46]  R. Stein,et al.  Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene , 1997, Molecular and cellular biology.

[47]  W. Clarke,et al.  Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 , 1997, Nature Genetics.

[48]  M. German,et al.  Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. , 1997, Genes & development.

[49]  R. Joshi,et al.  Phenotypic alterations in insulin-deficient mutant mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[50]  R. Stein,et al.  Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. , 1997, Endocrinology.

[51]  P. Gruss,et al.  The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas , 1997, Nature.

[52]  Genetique Moleculaire.  Phenotypic alterations in insulin-deficient mutant mice , 1997 .

[53]  P Gruss,et al.  Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. , 1997, Nature.

[54]  William L. Clarke,et al.  Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence , 1997, Nature Genetics.

[55]  H. Edlund,et al.  The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. , 1996, Development.

[56]  B. Hogan,et al.  PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. , 1996, Development.

[57]  C. Wright,et al.  Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8. , 1995, Developmental biology.

[58]  S. Bonner-Weir,et al.  Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model , 1995, Diabetes.

[59]  R. Stein,et al.  Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. , 1995, Development.

[60]  L. Orci,et al.  Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[61]  D. Finegood,et al.  Gender differences in the metabolic response to graded numbers of transplanted islets of Langerhans. , 1994, Endocrinology.

[62]  H. Edlund,et al.  Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.

[63]  K. Pang,et al.  Beta cells arise from glucose transporter type 2 (Glut2)-expressing epithelial cells of the developing rat pancreas. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[64]  H. C. Kaung.  Growth dynamics of pancreatic islet cell populations during fetal and neonatal development of the rat , 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

[65]  R. Stein,et al.  XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. , 1994, Molecular endocrinology.

[66]  D. Hanahan,et al.  Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide. , 1993, Development.

[67]  J. Marth,et al.  Tissue- and site-specific DNA recombination in transgenic mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[68]  V. Grill,et al.  Studies on sex dependency of B-cell susceptibility to streptozotocin in a rat model of type II diabetes mellitus. , 2009, Experimental and clinical endocrinology.

[69]  D. Hanahan,et al.  Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons , 1988, Cell.

[70]  J. A. D'Anna,et al.  Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells. , 1978, European journal of biochemistry.

[71]  R H Williams,et al.  An ultrastructural analysis of the developing embryonic pancreas. , 1972, Developmental biology.