Role of the RNA-dependent protein kinase in the regulated expression of genes in transfected cells.

[1]  C. Samuel,et al.  Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region , 1992, Journal of virology.

[2]  G. Feng,et al.  Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[3]  C. Samuel,et al.  Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. , 1992, Virology.

[4]  C. Samuel,et al.  Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase. , 1992, Virology.

[5]  Ganes C. Sen,et al.  Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase. , 1992, The Journal of biological chemistry.

[6]  O. Elroy-Stein,et al.  The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2 , 1992, Journal of virology.

[7]  A. Shatkin,et al.  Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene. , 1992, Virology.

[8]  J. Hershey,et al.  Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. , 1992, The Journal of biological chemistry.

[9]  C. Samuel,et al.  Biosynthesis of reovirus-specified polypeptides: expression of reovirus S1-encoded sigma 1NS protein in transfected and infected cells as measured with serotype specific polyclonal antibody. , 1991, Virology.

[10]  H. W. Chang,et al.  Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase. , 1991, Virology.

[11]  M. Katze,et al.  Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system , 1991, Molecular and cellular biology.

[12]  M. Mathews,et al.  Adenovirus virus-associated RNA and translation control , 1991, Journal of virology.

[13]  M. Katze,et al.  Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli. , 1991, Biochemistry.

[14]  P. Gros,et al.  TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. , 1991, The Journal of biological chemistry.

[15]  M. Katze,et al.  Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[16]  E. Paoletti,et al.  Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon , 1991 .

[17]  C. Samuel,et al.  Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. , 1991, Virology.

[18]  M. Katze,et al.  The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase , 1991, Journal of virology.

[19]  K. Hilse,et al.  Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI. , 1991, Nucleic Acids Research.

[20]  D. Kalvakolanu,et al.  Enhancement of expression of exogenous genes by 2-aminopurine. Regulation at the post-transcriptional level. , 1991, The Journal of biological chemistry.

[21]  M. Clemens,et al.  Translational control by the Epstein-Barr virus small RNA EBER-1. Reversal of the double-stranded RNA-induced inhibition of protein synthesis in reticulocyte lysates. , 1990, European journal of biochemistry.

[22]  M. Mathews,et al.  Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[23]  S. Goebel,et al.  The complete DNA sequence of vaccinia virus. , 1990, Virology.

[24]  B. Moss,et al.  Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor , 1990, Molecular and cellular biology.

[25]  B. Berkhout,et al.  Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[26]  I. Kerr,et al.  Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon , 1990, Cell.

[27]  M. Mathews,et al.  Interaction of adenovirus VA RNAI with the protein kinase DAI: Nonequivalence of binding and function , 1990, Cell.

[28]  C. Samuel,et al.  Biosynthesis of reovirus-specified polypeptides. 2-aminopurine increases the efficiency of translation of reovirus s1 mRNA but not s4 mRNA in transfected cells. , 1990, Virology.

[29]  J. Hershey Protein phosphorylation controls translation rates. , 1989, The Journal of biological chemistry.

[30]  M. Furtado,et al.  Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[31]  C. Samuel,et al.  Mechanism of interferon action. Activation of the human P1/eIF-2 alpha protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA. , 1989, Virology.

[32]  R. Bhat,et al.  Functional dissection of adenovirus VAI RNA , 1989, Journal of virology.

[33]  A. Shatkin,et al.  Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide sigma 3 in cotransfected COS cells , 1989, Journal of virology.

[34]  M. Mathews,et al.  Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI , 1989, Molecular and cellular biology.

[35]  V. Pathak,et al.  The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs , 1989, Molecular and cellular biology.

[36]  R. Silverman,et al.  Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA. , 1989, Nucleic acids research.

[37]  N. Sonenberg,et al.  Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism , 1989, Cell.

[38]  B. Jacobs,et al.  Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[39]  T. Hunter,et al.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. , 1988, Science.

[40]  T. Maniatis,et al.  2-Aminopurine selectively inhibits the induction of beta-interferon, c-fos, and c-myc gene expression. , 1988, Science.

[41]  C E Samuel,et al.  Biosynthesis of reovirus-specified polypeptides: effect of point mutation of the sequences flanking the 5'-proximal AUG initiator codons of the reovirus S1 and S4 genes on the efficiency of mRNA translation. , 1988, Virology.

[42]  V. Pathak,et al.  Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases , 1988, Molecular and cellular biology.

[43]  M. Nibert,et al.  Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3 , 1988, Molecular and cellular biology.

[44]  C. Samuel,et al.  Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning and nucleotide sequence of the reovirus serotype 1 Lang strain s2 mRNA which encodes the virion core polypeptide sigma 2. , 1987, Biochemical and biophysical research communications.

[45]  R. Kaufman,et al.  Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells , 1987, Molecular and cellular biology.

[46]  J. Hershey,et al.  Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. , 1987, The Journal of biological chemistry.

[47]  G. Akusjärvi,et al.  A mechanism by which adenovirus virus-associated RNAI controls translation in a transient expression assay , 1987, Molecular and cellular biology.

[48]  C. Samuel,et al.  Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase , 1986, Cell.

[49]  Michael B. Mathews,et al.  A mechanism for the control of protein synthesis by adenovirus VA RNAI , 1986, Cell.

[50]  G. Akusjärvi,et al.  Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs. , 1985, The EMBO journal.

[51]  R. Kaufman Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[52]  C. Samuel,et al.  Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo. , 1984, The Journal of biological chemistry.

[53]  C. Baglioni,et al.  Inhibition of mRNA binding to ribosomes by localized activation of dsRNA-dependent protein kinase , 1984, Nature.

[54]  A. De Benedetti,et al.  Phosphorylation of initiation factor eIF-2 alpha, binding of mRNA to 48 S complexes, and its reutilization in initiation of protein synthesis. , 1983, Journal of Biological Chemistry.

[55]  B. Safer 2B or not 2B: Regulation of the catalytic utilization of elF-2 , 1983, Cell.

[56]  C. Samuel,et al.  Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1. , 1982, The Journal of biological chemistry.

[57]  C. Baglioni,et al.  Structural requirements of polynucleotides for the activation of (2' - 5')An polymerase and protein kinase. , 1981, Nucleic acids research.

[58]  R. Friedman,et al.  Activation of human and mouse 2‐5A synthetases and mouse protein P1 kinase by nucleic acids , 1981, FEBS letters.

[59]  C. Baglioni,et al.  Structural requirements of double-stranded RNA for the activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells. , 1979, The Journal of biological chemistry.

[60]  C. E. Samuel Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[61]  R. Jackson,et al.  Phosphorylation of initiation factor eIF-2 and the control of reticulocyte protein synthesis , 1977, Cell.

[62]  W. Joklik,et al.  Reovirus-coded polypeptides in infected cells: isolation of two native monomeric polypeptides with affinity for single-stranded and double-stranded RNA, respectively. , 1976, Virology.

[63]  T. Hunt,et al.  The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates. , 1975, The Journal of biological chemistry.

[64]  C. Samuel,et al.  Mechanisms of the antiviral action of interferons. , 1988, Progress in nucleic acid research and molecular biology.

[65]  K C Zoon,et al.  Interferons and their actions. , 1987, Annual review of biochemistry.

[66]  T. Shenk,et al.  Impact of virus infection on host cell protein synthesis. , 1987, Annual review of biochemistry.

[67]  K. Moldave Eukaryotic protein synthesis. , 1985, Annual review of biochemistry.

[68]  P. Lengyel Biochemistry of interferons and their actions. , 1982, Annual review of biochemistry.