Population-Based Twin Study of the Effects of Migration From Finland to Sweden on Endothelial Function and Intima-Media Thickness

Finnish men have higher coronary heart disease (CHD) mortality than Swedish men do. To assess the impact of migration to a country with lower CHD mortality on subclinical atherosclerosis, we measured early functional and structural atherosclerotic vascular changes in twins discordant for migration from Finland to Sweden. Conventional CHD risk factors, flow-mediated dilatation (FMD) of the brachial artery, carotid intima-media thickness, and carotid artery compliance were measured in 74 male twin pairs (20 monozygous, 54 dizygous), aged 42 to 69 years, in which co-one twin had migrated more than 20 years ago permanently to Sweden. There were no significant differences in CHD risk factors except for diastolic blood pressure and body fat percentage, which were higher in Sweden. In all subjects, mean FMD was non-significantly higher in Sweden (5.7±4.3% vs 4.9±4.2%, P =0.22), but in monozygous twins the difference in FMD was highly significant (7.2±4.4 vs 3.7±2.9%, P =0.003). There was no significant difference in intima-media thickness or carotid artery compliance between Sweden and Finland. We conclude that in Finnish monozygous twins the endothelial function is better among the twins that have migrated to a country with lower CHD prevalence.

[1]  J. Kaprio,et al.  Migration and mortality: a 20 year follow up of Finnish twin pairs with migrant co-twins in Sweden , 2002, Journal of epidemiology and community health.

[2]  J. Viikari,et al.  Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension , 2000, Hypertension.

[3]  E. Rocha.  [Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease]. , 2000, Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.

[4]  A. Steptoe,et al.  Mental Stress Induces Transient Endothelial Dysfunction in Humans , 2000, Circulation.

[5]  J. Kooner,et al.  Methylenetetrahydrofolate Reductase 677 C →T Mutation and Coronary Heart Disease Risk in UK Indian Asians , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[6]  O. Raitakari,et al.  Noninvasive assessment of brachial artery endothelial function with digital ultrasound and 13-MHz scanning frequency: feasibility of measuring the true inner luminal diameter using the intima-lumen interface. , 2000, Ultrasound in medicine & biology.

[7]  O. Raitakari,et al.  Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. , 2000, Journal of the American College of Cardiology.

[8]  O. Raitakari,et al.  Testing for endothelial dysfunction , 2000, Annals of medicine.

[9]  O. Raitakari,et al.  Westernization of Chinese adults and increased subclinical atherosclerosis. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[10]  J. Stein,et al.  Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. , 1999, Circulation.

[11]  J. Tardif,et al.  Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial. , 1999, Circulation.

[12]  H. Tunstall-Pedoe,et al.  Contribution of trends in survival and coronar y-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA Project populations , 1999, The Lancet.

[13]  J. Kooner,et al.  Abnormalities of vascular endothelial function may contribute to increased coronary heart disease risk in UK Indian Asians , 1999, Heart.

[14]  J. Viikari,et al.  Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[15]  R. Kronmal,et al.  Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. , 1999, The New England journal of medicine.

[16]  A. Zwinderman,et al.  B-mode ultrasound assessment of pravastatin treatment effect on carotid and femoral artery walls and its correlations with coronary arteriographic findings: a report of the Regression Growth Evaluation Statin Study (REGRESS). , 1998, Journal of the American College of Cardiology.

[17]  G. Plotnick,et al.  Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. , 1997, JAMA.

[18]  S. Rosfors,et al.  A methodological study of arterial wall function using ultrasound technique. , 1997, Clinical physiology.

[19]  D. Glogar,et al.  Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. , 1997, Atherosclerosis.

[20]  S. Johansson,et al.  Attendance at cultural events, reading books or periodicals, and making music or singing in a choir as determinants for survival: Swedish interview survey of living conditions , 1996, BMJ.

[21]  A. Yeung,et al.  Close relation of endothelial function in the human coronary and peripheral circulations. , 1995, Journal of the American College of Cardiology.

[22]  W E Haefeli,et al.  Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. , 1995, Circulation.

[23]  D. Grobbee,et al.  Carotid artery intima‐media thickness as an indicator of generalized atherosclerosis , 1994, Journal of internal medicine.

[24]  J. Salonen,et al.  Ultrasonographic manifestations of common carotid atherosclerosis in elderly eastern Finnish men. Prevalence and associations with cardiovascular diseases and risk factors. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[25]  L. Berkman,et al.  Genetic susceptibility to death from coronary heart disease in a study of twins. , 1994, The New England journal of medicine.

[26]  D. Celermajer,et al.  Cigarette Smoking Is Associated With Dose‐Related and Potentially Reversible Impairment of Endothelium‐Dependent Dilation in Healthy Young Adults , 1993, Circulation.

[27]  R. Ross.  The pathogenesis of atherosclerosis: a perspective for the 1990s , 1993, Nature.

[28]  J. Lasker,et al.  The Roseto effect: a 50-year comparison of mortality rates. , 1992, American journal of public health.

[29]  J. Salonen,et al.  Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

[30]  L. Chambless,et al.  Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. , 1991, American journal of epidemiology.

[31]  M. Arstila,et al.  New ergometric reference values for clinical exercise tests. , 1990, Scandinavian journal of clinical and laboratory investigation.

[32]  N. Hertzer,et al.  Coronary angiography in 506 patients with extracranial cerebrovascular disease. , 1985, Archives of internal medicine.

[33]  A. Ahlbom,et al.  Incidence of myocardial infarction among male Finnish immigrants in relation to length of stay in Sweden. , 1982, International journal of epidemiology.

[34]  P. Zimmet.  Epidemiology of Diabetes and its Macrovascular Manifestations in Pacific Populations: The Medical Effects of Social Progress , 1979, Diabetes Care.

[35]  R. Worth,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Coronary heart disease risk factors in Japan and Hawaii. , 1977, The American journal of cardiology.

[36]  M Marmot,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Incidence of myocardial infarction and death from coronary heart disease. , 1977, The American journal of cardiology.

[37]  Teven,et al.  MORTALITY FROM CORONARY HEART DISEASE IN SUBJECTS WITH TYPE 2 DIABETES AND IN NONDIABETIC SUBJECTS WITH AND WITHOUT PRIOR MYOCARDIAL INFARCTION , 2000 .

[38]  H. Tunstall-Pedoe,et al.  Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. , 1999, Lancet.

[39]  L Crouse,et al.  Stress echocardiography: recommendations for performance and interpretation of stress echocardiography. Stress Echocardiography Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. , 1998, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[40]  J. Kaprio,et al.  The Finnish Twin Registry: formation and compilation, questionnaire study, zygosity determination procedures, and research program. , 1978, Progress in clinical and biological research.