The apolipoprotein E gene and Taq1A polymorphisms in childhood obesity.

Obesity is a multifactorial disease that is influenced by genetic and environmental factors. The apolipoprotein E (Apo E) polymorphism has been reported to influence some lipid profile abnormalities associated with obesity in childhood. In this study, the relationship between the Apo E gene and Taq1A polymorphisms with childhood obesity has been studied. Regarding the Apo E genotypes, e3/4 was the most frequent in both the patient and control groups. Further, there was a significance between the Apo E genotypes with low density lipoprotein and total cholesterol levels. However, no relationship was found between the Taq1A polymorphism and obesity. In conclusion, polygenic inheritance should be kept in mind when dealing with childhood obesity.

[1]  D. Comings,et al.  Genetic variants of the human obesity (OB) gene: association with body mass index in young women, psychiatric symptoms, and interaction with the dopamine D2 receptor (DRD2) gene. , 1996, Molecular psychiatry.

[2]  D. Grandy,et al.  PCR detection of the TaqA RFLP at the DRD2 locus. , 1993, Human molecular genetics.

[3]  L. Belo,et al.  Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. , 2009, Archives of pediatrics & adolescent medicine.

[4]  S. Seixas,et al.  Influence of Apolipoprotein E Polymorphism on Cardiovascular Risk Factors in Obese Children , 2003, Annals of Nutrition and Metabolism.

[5]  P. Zimmet,et al.  The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity. , 2003, Diabetes, nutrition & metabolism.

[6]  Caroline Reid,et al.  Reward sensitivity and the D2 dopamine receptor gene: A case-control study of binge eating disorder , 2008, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[7]  G. Béréziat,et al.  Relation of Apolipoprotein E Polymorphism to Lipid Metabolism in Obese Children , 1997, Pediatric Research.

[8]  M. Ridderstråle,et al.  Interaction between PPARG Pro12Ala and ADIPOQ G276T concerning cholesterol levels in childhood obesity. , 2009, International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.

[9]  E. Molinari,et al.  D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity , 2007, Eating and weight disorders : EWD.

[10]  S. Y. Kimm,et al.  Quantitative effects of the apolipoprotein E polymorphism in a biracial sample of 9-10-year-old girls. , 1996, Atherosclerosis.

[11]  S. Srinivasan,et al.  The relation of apolipoprotein E polymorphism to multiple cardiovascular risk in children: the Bogalusa Heart Study. , 1996, Atherosclerosis.

[12]  D. Agarwal,et al.  Distribution of Apolipoprotein E (APOE) Genotypes in a Siberian Female Population Sample , 2001 .

[13]  D. Grandy,et al.  D2 dopamine receptor gene and obesity. , 1994, The International journal of eating disorders.

[14]  E. Boerwinkle,et al.  Effects of apolipoprotein E genotype on blood cholesterol in adolescent girls. , 2009, American journal of preventive medicine.

[15]  C. Vaisse,et al.  Lessons from extreme human obesity: monogenic disorders. , 2008, Endocrinology and metabolism clinics of North America.

[16]  K. Kaku,et al.  Type III hyperlipoproteinema with apolipoprotein E2/2 genotype in Japan , 2002, Clinical genetics.

[17]  J. Michael Schurr,et al.  Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele , 2008, Science.