Abstract PR10: Is CNS availability for oncology a no-brainer? Discovery of PF-06463922, a novel small molecule inhibitor of ALK/ROS1 with preclinical brain availability and broad spectrum potency against ALK-resistant mutations.
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N. Sach | M. McTigue | H. Zou | M. Edwards | T. Smeal | S. Bailey | M. Collins | Wenyue Hu | B. Burke | Justine L. Lam | P. Richardson | Hieu Lam | T. Johnson | R. Hoffman | Lars D. Engstrom | Graham L. Smith | J. Cui | J. Hoffman | P. Le | Mingying He | Ya-Li Deng | Qinhua Huang | J. Deal | C. Palmer | K. Steven