Mitochondria, oxygen free radicals, disease and ageing.

[1]  B. Robinson,et al.  Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. , 2000, Free radical biology & medicine.

[2]  G. Barja,et al.  Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[3]  T. Zglinicki,et al.  Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts. , 2000, Free radical biology & medicine.

[4]  J. Zweier,et al.  Evidence against the Generation of Free Hydroxyl Radicals from the Interaction of Copper,Zinc-Superoxide Dismutase and Hydrogen Peroxide* , 1999, The Journal of Biological Chemistry.

[5]  Liping Li,et al.  The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  R. S. Sohal,et al.  Comparisons of coenzyme Q bound to mitochondrial membrane proteins among different mammalian species. , 1999, Free radical biology & medicine.

[7]  H. Zhu,et al.  Detection of mitochondria-derived reactive oxygen species production by the chemilumigenic probes lucigenin and luminol. , 1999, Biochimica et biophysica acta.

[8]  L. Oberley,et al.  Altered levels of primary antioxidant enzymes in progeria skin fibroblasts. , 1999, Biochemical and biophysical research communications.

[9]  J. Labbé,et al.  CLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans , 1999, The EMBO journal.

[10]  J. Casida,et al.  NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[11]  F. Sluse,et al.  Generation of superoxide anion by mitochondria and impairment of their functions during anoxia and reoxygenation in vitro. , 1998, Free radical biology & medicine.

[12]  R. Feuers.  The Effects of Dietary Restriction on Mitochondrial Dysfunction in Aging a , 1998, Annals of the New York Academy of Sciences.

[13]  L. Gille,et al.  The Biochemical, Pathophysiological, and Medical Aspects of Ubiquinone Function , 1998, Annals of the New York Academy of Sciences.

[14]  M. Beal,et al.  Elevated “Hydroxyl Radical” Generation In Vivo in an Animal Model of Amyotrophic Lateral Sclerosis , 1998, Journal of neurochemistry.

[15]  J. Lunardi,et al.  The 49‐kDa subunit of NADH‐ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone‐related inhibitors , 1998, FEBS letters.

[16]  J. Golenser,et al.  Transgenic mice with elevated level of CuZnSOD are highly susceptible to malaria infection. , 1998, Free radical biology & medicine.

[17]  L. Oberley,et al.  Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studies , 1998, Journal of cellular physiology.

[18]  A. Elia,et al.  Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons , 1998, Nature Genetics.

[19]  T. Ohnishi,et al.  Iron-sulfur clusters/semiquinones in complex I. , 1998, Biochimica et biophysica acta.

[20]  B. Robinson.  Human complex I deficiency: clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect. , 1998, Biochimica et biophysica acta.

[21]  S. Petersen,et al.  Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. , 1998, Experimental cell research.

[22]  E. Gahtan,et al.  Reversible impairment of long‐term potentiation in transgenic Cu/Zn‐SOD mice , 1998, The European journal of neuroscience.

[23]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[24]  M. Dubois‐Dauphin,et al.  Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. , 1997, Science.

[25]  B. Robinson,et al.  Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency. , 1997, The Journal of clinical investigation.

[26]  F. Chu,et al.  The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. , 1997, Archives of biochemistry and biophysics.

[27]  T. Yagi,et al.  The Proton-translocating NADH-Quinone Oxidoreductase (NDH-1) of Thermophilic Bacterium Thermus thermophilus HB-8 , 1997, The Journal of Biological Chemistry.

[28]  M. Brand,et al.  The Physiological Significance of Mitochondrial Proton Leak in Animal Cells and Tissues , 1997, Bioscience reports.

[29]  U. Brandt,et al.  Proton-translocation by membrane-bound NADH:ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction. , 1997, Biochimica et biophysica acta.

[30]  M. Matzuk,et al.  Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[31]  D. S. St. Clair,et al.  Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells. , 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[32]  D. S. St. Clair,et al.  The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. , 1996, The Journal of clinical investigation.

[33]  B. Robinson,et al.  Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. , 1996, The Journal of clinical investigation.

[34]  B. Robinson,et al.  Familial Cardiomyopathy with Cataracts and Lactic Acidosis: A Defect in Complex I (NADH-Dehydrogenase) of the Mitochondria Respiratory Chain , 1996, Pediatric Research.

[35]  C. Epstein,et al.  Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase , 1995, Nature Genetics.

[36]  G. Saretzki,et al.  Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? , 1995, Experimental cell research.

[37]  A. Ruiz-Argüelles,et al.  [The aging process]. , 1995, Gaceta medica de Mexico.

[38]  S. Hekimi,et al.  Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. , 1995, Genetics.

[39]  P. Kruk,et al.  DNA damage and repair in telomeres: relation to aging. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[40]  A. Beaudet,et al.  Oxidative Phosphorylation Diseases: Chapter 46. , 1995 .

[41]  R. S. Sohal,et al.  Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. , 1994, Science.

[42]  D. Flint,et al.  The inactivation of Fe-S cluster containing hydro-lyases by superoxide. , 1993, The Journal of biological chemistry.

[43]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[44]  K. Avraham,et al.  Down's syndrome: morphological remodelling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice , 1991, Journal of neurocytology.

[45]  B. Trumpower,et al.  The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex. , 1990, The Journal of biological chemistry.

[46]  C. Harley,et al.  Telomeres shorten during ageing of human fibroblasts , 1990, Nature.

[47]  D. Harman,et al.  The aging process. , 1981, Basic life sciences.

[48]  C. Ragan,et al.  Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone , 1987, FEBS letters.

[49]  W. Pryor.  Oxy-radicals and related species: their formation, lifetimes, and reactions. , 1986, Annual review of physiology.

[50]  R. Cutler,et al.  Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[51]  I. Fridovich,et al.  Superoxide radical and superoxide dismutases: threat and defense. , 1980, Acta physiologica Scandinavica. Supplementum.

[52]  K. Takeshige,et al.  NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. , 1979, The Biochemical journal.

[53]  L. Packer,et al.  Low oxygen concentration extends the lifespan of cultured human diploid cells , 1977, Nature.

[54]  A. Boveris,et al.  Mitochondrial production of superoxide radical and hydrogen peroxide. , 1977, Advances in experimental medicine and biology.

[55]  M. Reivich,et al.  Tissue Hypoxia and Ischemia , 1977, Advances in Experimental Medicine and Biology.